ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

July 6, 2020

C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression

Nature Communications
Yu SunJunjie U Guo
July 4, 2020

Quantitative patterns of motor cortex proteinopathy across ALS genotypes

Acta Neuropathologica Communications
Matthew NolanOlaf Ansorge
June 20, 2020

A multi-center study of neurofilament assay reliability and inter-laboratory variability

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Elizabeth GrayMarkus Otto
June 9, 2020
Open Access

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

Frontiers in Molecular Neuroscience
Javier H JaraP Hande Ozdinler
June 27, 2020
Open Access

Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis

Acta Neuropathologica Communications
J SaulN Bakkar
June 25, 2020
Open Access

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis

Genes
Daniel M BeanAlfredo Iacoangeli
June 27, 2020
Review
Open Access

MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes

International Journal of Molecular Sciences
Héctor Albert-GascóFrancisco E Olucha-Bordonau
July 4, 2020

Concurrent sodium channelopathies and amyotrophic lateral sclerosis supports shared pathogenesis

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
John P FranklinMichael G Hanna
June 20, 2020

Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights

Critical Reviews in Eukaryotic Gene Expression
Keshav ThakurAkshay Anand
June 11, 2020
Review
Open Access

Gut-Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization

International Journal of Molecular Sciences
Bruno TiloccaViviana Greco
July 3, 2020
Open Access

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis

Brain Communications
Greig JoilinMajid Hafezparast

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