ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

March 7, 2021
Open Access

Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases.

Swapnil GuptaKulbhushan Sharma
March 7, 2021
Open Access

The Role of the Inflammasome in Neurodegenerative Diseases.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Federica PianconeMario Clerici
March 7, 2021
Open Access

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions.

International Journal of Molecular Sciences
Paloma A HarchaBrigitte van Zundert
March 5, 2021
Open Access

Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies.

Faculty Reviews
Lauren M Gittings, Rita Sattler
March 4, 2021

Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation.

Nature Reviews. Neuroscience
Paraskevi TziortzoudaFrank Hirth
March 4, 2021

The emerging role of the chondroitin sulfate proteoglycan family in neurodegenerative diseases.

Reviews in the Neurosciences
Jia-Zhe LinWei-Jiang Zhao
March 2, 2021
Open Access

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

BioRxiv : the Preprint Server for Biology
Taty AnTatyana A Shelkovnikova
March 2, 2021
Open Access

Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS.

Frontiers in Molecular Neuroscience
Ya-Fei ZhaoPeter Illes
February 28, 2021

Mitochondrial Dysfunction and Traffic Jams in Amyotrophic Lateral Sclerosis.

Rishabh JhanjiSimona Bungau
February 25, 2021

Phenotypic and molecular diversities of spinocerebellar ataxia type 2 in Japan.

Journal of Neurology
Rino InadaSusumu Kusunoki
February 25, 2021

Main Role of Antibodies in Demyelination and Axonal Damage in Multiple Sclerosis.

Cellular and Molecular Neurobiology
Ursula MuñozMari Cruz Sadaba
February 24, 2021
Open Access

Gastrointestinal biopsies and amyotrophic lateral sclerosis - results from a cohort study of 1.1 million individuals.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Jiangwei SunFang Fang
February 23, 2021
Open Access

The multi-faceted role of mitochondria in the pathology of Parkinson's disease.

Journal of Neurochemistry
Dennison TrinhJoanne E Nash
February 21, 2021

Implication of post-translationally modified SOD1 in pathological aging.

Kashfia ShafiqJiming Kong
February 20, 2021
Open Access

No association of GSTP1 rs1695 polymorphism with amyotrophic lateral sclerosis: A case-control study in the Brazilian population.

PloS One
Jéssica Barletto de Sousa BarrosAngela Adamski da Silva Reis
February 16, 2021
Open Access

Mitochondrial Redox Signaling Is Critical to the Normal Functioning of the Neuronal System.

Frontiers in Cell and Developmental Biology
Olena OdnokozSvetlana N Radyuk
February 16, 2021
Open Access

The role of immune-mediated alterations and disorders in ALS disease.

Human Immunology
João Rodrigues Lima-JuniorAlessandro Sette

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