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ALS: Prions

ALS: Prions diagram by Designua, Shutterstock
Designua, Shutterstock

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

Top 20 most recent papers
May 17, 2020
ReviewOpen Access

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy

International Journal of Molecular Sciences
Laura GattiAnna Bersano
May 26, 2020

The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species

The EMBO Journal
Jessica TittelmeierCarmen Nussbaum-Krammer
May 23, 2020

Long noncoding RNA Gm20319, acting as competing endogenous RNA, regulated GNE expression by sponging miR-7240-5p to involve in deoxynivalenol-induced liver damage in vitro

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yuxiao LiaoWei Yang
May 11, 2020
Review

Prions: Roles in Development and Adaptive Evolution

Journal of Molecular Evolution
Jamie D Dixson, Rajeev K Azad
May 18, 2020

Soy flavonoids prevent cognitive deficits induced by intra-gastrointestinal administration of beta-amyloid

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Julia Y H LiuJohn A Rudd
May 11, 2020

Distribution of TDP-43 Pathology in Hippocampal Synaptic Relays Suggests Transsynaptic Propagation in Frontotemporal Lobar Degeneration

Journal of Neuropathology and Experimental Neurology
Pouya JamshidiChangiz Geula
May 23, 2020
Review

Evidence of distinct α-synuclein strains underlying disease heterogeneity

Acta Neuropathologica
Sara A M Holec, Amanda L Woerman
May 14, 2020

Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V

Protein Engineering, Design & Selection : PEDS
Filip ClaesJoost Schymkowitz

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