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ALS: Prions

ALS: Prions diagram by undefined

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

Top 20 most recent papers
bioRxiv

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

bioRxivDecember 6, 2019
Kirby M DonnellyMargaret M Panning Pearce
16
bioRxiv

Comprehensive identification of HSP70/HSC70 Chaperone Clients in Human Cells

bioRxivDecember 4, 2019
Seung W RyuTanya T. Paull
8
bioRxiv

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

bioRxivDecember 6, 2019
Richard ZimmermannMarisa Loi
2
Nature Neuroscience

α-Synuclein strains target distinct brain regions and cell types

Nature NeuroscienceDecember 2, 2019
Angus LauJ Colton Watts
107
4
Journal of Molecular Biology

Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity

Journal of Molecular BiologyDecember 7, 2019
Jun-Jie HuangYi Liang
ACS Chemical Neuroscience

A native mass spectrometry-based method for studying stilbenoid effects on the stabilities and aggregation of Cu, Zn-superoxide dismutase

ACS Chemical NeuroscienceDecember 10, 2019
Xiaoyu ZhuangJian-Zhong Lu
Seminars in Cell & Developmental Biology

Prions and Prion-like assemblies in neurodegeneration and immunity: The emergence of universal mechanisms across health and disease

Seminars in Cell & Developmental BiologyDecember 6, 2019
Ailis O'CarrollYann Gambin
Gene Therapy

The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model

Gene TherapyDecember 9, 2019
Weisong DuanChun-Yan Li
Metallomics : Integrated Biometal Science

Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure

Metallomics : Integrated Biometal ScienceDecember 10, 2019
Shao-Ping ZhangGarth J S Cooper
Scientific Reports

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids

Scientific ReportsDecember 9, 2019
Edoardo BistaffaFabio Moda
Biomolecules

Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1

BiomoleculesDecember 4, 2019
Sourav ChowdhuryKrishnananda Chattopadhyay
Antioxidants

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

AntioxidantsDecember 8, 2019
Donald G MatthewsAmala Soumyanath
Current Pharmaceutical Design

Neurofilament proteins as prognostic biomarkers in neurological disorders

Current Pharmaceutical DesignDecember 10, 2019
Yi-Chen LeeBak-Sau Yip
Analytical Chemistry

A general mass spectrometry-based method of quantitating prion polymorphisms from heterozygous CWD-infected cervids

Analytical ChemistryDecember 9, 2019
Christopher J SilvaDebbie I McKenzie
Environmental Pollution

miR398 is involved in the relief of phenanthrene-induced oxidative toxicity in wheat roots

Environmental PollutionNovember 30, 2019
Jin-Feng LiXin-hua Zhan
EBioMedicine

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

EBioMedicineNovember 28, 2019
Anastasya BirgerBenjamin E Reubinoff
3
1
Ecology and Evolution

Differential gene expression in chronic wasting disease-positive white-tailed deer (Odocoileus virginianus )

Ecology and EvolutionNovember 1, 2019
Emma K Trone-LaunerChristopher N Jacques
1
1
Aging and Disease

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux

Aging and DiseaseDecember 1, 2019
Xiao-Jie ZhangYu Wu Zhao
1
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery

Reticulated Platelets as Predictor of Myocardial Injury and 30 Day Mortality After Non-cardiac Surgery

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular SurgeryDecember 4, 2019
Armelle J A MeershoekGert Jan de Borst
Aging and Disease

Genetic Spectrum and Variability in Chinese Patients with Amyotrophic Lateral Sclerosis

Aging and DiseaseDecember 1, 2019
Zhi-Jun LiuZhi-Ying Wu
1

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