ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

August 6, 2020
Open Access

Disease-modifying effects of an SCAF4 structural variant in a predominantly SOD1 ALS cohort

Neurology. Genetics
Julia PytteP Anthony Akkari
August 8, 2020
Open Access

11 C-PK11195 PET-based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis

Annals of Clinical and Translational Neurology
Giacomo TondoDaniela Perani
August 2, 2020

Identification of the prion-related protein gene (PRNT) sequences in various species of the Cervidae family

Molecular Biology Reports
In-Soon RohByung-Hoon Jeong
August 11, 2020

Processing bovine intestinal mucosa to active heparin removes spiked BSE agent

Biologicals : Journal of the International Association of Biological Standardization
Omozusi AndrewsLuisa Gregori
August 11, 2020
Open Access

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

Nucleic Acids Research
Eric Vallabh MinikelSonia M Vallabh
August 6, 2020
Open Access

Differential protein expression in diverse brain areas of Parkinson's and Alzheimer's disease patients

Scientific Reports
A R Esteves, S M Cardoso
August 3, 2020

Intracisternal injection of beta-amyloid seeds promotes cerebral amyloid angiopathy

Brain, Behavior, and Immunity
Qiuju YuanZhi-Xiu Lin
August 5, 2020

Benzimidazole based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T

Journal of Neurochemistry
Narayanaperumal PravinMaheswaran Shanmugam
August 10, 2020
Open Access

A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis

Nature Communications
Penny J NorsworthyEmmanuelle A Viré
August 5, 2020

Overexpression of plant ferredoxin-like protein promotes salinity tolerance in rice (Oryza sativa)

Plant Physiology and Biochemistry : PPB
Hsiang-En HuangMang-Jye Ger
August 11, 2020
Case Report
Open Access

Dressing Apraxia as Initial Manifestation of Creutzfeldt-Jakob Disease

Tremor and Other Hyperkinetic Movements
Josef G HeckmannStefan Schwab
August 14, 2020
Open Access

---A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

The Journal of Biological Chemistry
Carola Munoz-MontesinoMichel Dron

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