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ALS: Prions

ALS: Prions diagram by Designua, Shutterstock
Designua, Shutterstock

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

Top 20 most recent papers
Neurology

Autoantibodies against the prion protein in individuals with PRNP mutations

NeurologyFebruary 27, 2020
Karl FrontzekTHAUTAN-MC Study Group
Current Opinion in Neurobiology

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

Current Opinion in NeurobiologyFebruary 25, 2020
Georg MeislDavid Klenerman
4
135
1
Cell Reports

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Cell ReportsFebruary 27, 2020
Emiel MichielsFrederic Rousseau
bioRxiv

Phe-Gly Motifs Drive Fibrillization of TDP-43's Prion-Like Domain Droplets

bioRxivFebruary 21, 2020
David Pantoja-UcedaMiguel Mompean
16
Neuropharmacology

Genetic architecture of neurodegenerative dementias

NeuropharmacologyFebruary 26, 2020
Jordi ClarimonAgustín Ruiz
27
European Psychiatry : the Journal of the Association of European Psychiatrists

An atlas of genetic correlations between psychiatric disorders and human blood plasma proteome

European Psychiatry : the Journal of the Association of European PsychiatristsFebruary 26, 2020
Shiqiang ChengFeng Zhang
2
Advances in Experimental Medicine and Biology

Tau Prion-Like Propagation: State of the Art and Current Challenges

Advances in Experimental Medicine and BiologyFebruary 26, 2020
Simon Dujardin, Bradley T Hyman
Advances in Experimental Medicine and Biology

Structure of NFT: Biochemical Approach

Advances in Experimental Medicine and BiologyFebruary 26, 2020
Masato Hasegawa
Angewandte Chemie

On the Binding of Congo Red to Amyloid Fibrils

Angewandte ChemieFebruary 20, 2020
Alba EspargaróRaimon Sabaté
9
Translational Neurodegeneration

Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions

Translational NeurodegenerationFebruary 26, 2020
Seiji KajiRyosuke Takahashi
2
bioRxiv

Protein-protein interactions in neurodegenerative diseases: a conspiracy theory.

bioRxivFebruary 11, 2020
Travis B ThompsonAlain Goriely
11
ACS Medicinal Chemistry Letters

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity

ACS Medicinal Chemistry LettersFebruary 20, 2020
Jean-Marc M GrandjeanNick A Paras
2
1
The Journal of Physical Chemistry. B

Enhancement of Oxidative Reaction by the Intramolecular Electron Transfer between the Coordinated Redox-Active Metal Ions in SOD1

The Journal of Physical Chemistry. BFebruary 27, 2020
Takumi OhyamaTakakazu Nakabayashi

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