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ALS: Stress Granules

ALS: Stress Granules diagram by Van Damme et al, Wikimedia
Van Damme et al, Wikimedia

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

Top 20 most recent papers
bioRxiv

Osmotic stress-induced, rapid clustering of IGF2BP proteins nucleates stress granule assembly

bioRxivNovember 18, 2019
Wei-Jie ZengJie Yao
10
bioRxiv

The Trk fused gene-product (Tfg) is part of a 600-700kDa CARMA1 complex

bioRxivDecember 5, 2019
Marcus GrohmannDirk Mielenz
2
bioRxiv

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

bioRxivNovember 11, 2019
Júlia Canet-PonsGeorg Auburger
3
bioRxiv

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

bioRxivAugust 5, 2019
Richard J WheelerAnthony A Hyman
141
66
Journal of Experimental & Clinical Cancer Research : CR

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

Journal of Experimental & Clinical Cancer Research : CRSeptember 5, 2019
Yong WangDan Yue
International Journal of Molecular Sciences

Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation

International Journal of Molecular SciencesJanuary 18, 2020
Cora Sandra ThielOliver Ullrich
bioRxiv

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

bioRxivOctober 12, 2019
Chen WangYanshan Fang
26
5
Nature Communications

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Nature CommunicationsDecember 8, 2019
Ian CasciUdai Bhan Pandey
28
1
1
Veterinary Microbiology

GTPase-activating protein-binding protein 1 (G3BP1) plays an antiviral role against porcine epidemic diarrhea virus

Veterinary MicrobiologySeptember 11, 2019
Kabita PandeyXiuqing Wang
1
Cancer Medicine

Elevated expression of G3BP1 associates with YB1 and p-AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection

Cancer MedicineSeptember 28, 2019
Hongmei ZhengSongqing Fan
Cell Death & Disease

G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response

Cell Death & DiseaseDecember 13, 2019
Wenping YangHaixue Zheng
1
Journal of Neuro-oncology

Correction to: G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

Journal of Neuro-oncologySeptember 4, 2019
L F F BittencourtL S Barcelos
Acta Neuropathologica Communications

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

Acta Neuropathologica CommunicationsJuly 20, 2019
Laurence RenaudJean-Pierre Julien
3
1
46
ACS Chemical Biology

A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS

ACS Chemical BiologyJune 27, 2019
Liberty Francois-MoutalMay Khanna
46
1
1
27
Science Signaling

PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing

Science SignalingNovember 28, 2019
Siqi HuFei Guo
24
[Rinshō ketsueki] The Japanese journal of clinical hematology

Genetic defects of chromosome 5q and 7q in myeloid neoplasms

[Rinshō ketsueki] The Japanese journal of clinical hematologyAugust 9, 2019
Naoko Hosono
Scientific Reports

Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism

Scientific ReportsSeptember 21, 2019
Muhammad AslamJakob von Engelhardt
2
1
6
Bioorganic & Medicinal Chemistry Letters

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

Bioorganic & Medicinal Chemistry LettersJanuary 14, 2020
Dean G BrownHeike J Wobst
26
1
Anticancer Research

G3BP1 Depletion Increases Radiosensitisation by Inducing Oxidative Stress in Response to DNA Damage

Anticancer ResearchNovember 11, 2019
Eugene ChoHyun Jin Shin
Nature Structural & Molecular Biology

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

Nature Structural & Molecular BiologyJune 27, 2019
Qin CaoDavid S Eisenberg
26
1
32
1

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