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ALS: Stress Granules

ALS: Stress Granules diagram by Van Damme et al, Wikimedia
Van Damme et al, Wikimedia

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

Top 20 most recent papers
Biochemical and Biophysical Research Communications

Computational screening of potential regulators for mRNA-protein expression level discrepancy

Biochemical and Biophysical Research CommunicationsDecember 19, 2019
Xiaobin WuYuan Zhou
1
Nature Reviews. Neuroscience

Stress granules and neurodegeneration

Nature Reviews. NeuroscienceOctober 5, 2019
Benjamin Wolozin, Pavel Ivanov
47
1
4
158
1
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction

The Journal of Neuroscience : the Official Journal of the Society for NeuroscienceOctober 18, 2019
Mathieu BartolettiKristi A Wharton
22
1
13
Molecular and Cellular Biology

The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics

Molecular and Cellular BiologySeptember 5, 2019
Jozsef GalHaining Zhu
4
12
Neurobiology of Disease

UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins

Neurobiology of DiseaseFebruary 7, 2020
Simona RossiMauro Cozzolino
5
1
Advances in Experimental Medicine and Biology

RNA Granules and Their Role in Neurodegenerative Diseases

Advances in Experimental Medicine and BiologyDecember 8, 2019
Hadjara Sidibé, Christine Vande Velde
3
1
Frontiers in Cellular Neuroscience

Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner

Frontiers in Cellular NeuroscienceNovember 7, 2019
Jessica BellmannJared Sterneckert
7
1
13
Journal of Experimental & Clinical Cancer Research : CR

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

Journal of Experimental & Clinical Cancer Research : CRSeptember 5, 2019
Yong WangDan Yue
Molecular Cell

Structure-Mediated RNA Decay by UPF1 and G3BP1

Molecular CellFebruary 5, 2020
Joseph W FischerAnthony K L Leung
90
5
1
The Journal of Cell Biology

Stress granules regulate stress-induced paraspeckle assembly

The Journal of Cell BiologyOctober 23, 2019
Haiyan AnTatyana A Shelkovnikova
32
1
30

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