ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

September 5, 2019
Open Access

The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics

Molecular and Cellular Biology
Jozsef GalHaining Zhu
November 30, 2019
Open Access

Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules

The Journal of Biological Chemistry
Friederike HansPhilipp J Kahle
February 13, 2020
Review
Open Access

Implications of Selective Autophagy Dysfunction for ALS Pathology

Cells
Emiliano VicencioUte Woehlbier
August 11, 2019

The prion-like protein kinase Sky1 is required for efficient stress granule disassembly

Nature Communications
Jenifer E ShattuckEric D Ross
January 29, 2020
Preprint
Open Access

Spatio-temporal Proteomic Analysis of Stress Granule disassembly using APEX Reveals Regulation by SUMOylation and links to ALS pathogenesis

BioRxiv : the Preprint Server for Biology
Marmor-Kollet HagaiEran Hornstein
October 23, 2019
Open Access

Stress granules regulate stress-induced paraspeckle assembly

The Journal of Cell Biology
Haiyan AnTatyana A Shelkovnikova
November 11, 2019
Preprint
Open Access

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

BioRxiv : the Preprint Server for Biology
Julia Canet-PonsGeorg Auburger
December 26, 2019
Open Access

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Cell Reports
Tatyana A ShelkovnikovaVladimir L Buchman
January 14, 2020
Review

Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia

Bioorganic & Medicinal Chemistry Letters
Dean G BrownHeike J Wobst
May 4, 2020
Review

Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules

Wiley Interdisciplinary Reviews. RNA
Klára FrydrýškováMartin Pospíšek
October 19, 2019
Review

Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum

Neurobiology of Disease
Yalda Baradaran-HeraviJulie van der Zee
September 5, 2019
Open Access

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

Journal of Experimental & Clinical Cancer Research : CR
Yong WangDan Yue
July 2, 2020
Open Access

Neuronal RNA-binding protein dysfunction in multiple sclerosis cortex

Annals of Clinical and Translational Neurology
Hannah E SalapaMichael C Levin
December 8, 2019

RNA Granules and Their Role in Neurodegenerative Diseases

Advances in Experimental Medicine and Biology
Hadjara Sidibé, Christine Vande Velde

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