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ALS: Stress Granules

ALS: Stress Granules diagram by Philip Van Damme, Wim Robberecht, and Ludo Van Den Bosch
Philip Van Damme, Wim Robberecht, and Ludo Van Den Bosch

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

Top 20 most recent papers
Molecular Cell

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

Molecular CellApril 14, 2019
Bo Shen WangMondira Kundu
35
7
1
58
1
bioRxiv

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

bioRxivOctober 12, 2019
Chen WangYanshan Fang
26
bioRxiv

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

bioRxivNovember 11, 2019
Júlia Canet-PonsGeorg W J Auburger
3
Nature Reviews. Neuroscience

Stress granules and neurodegeneration

Nature Reviews. NeuroscienceOctober 3, 2019
Benjamin L Wolozin, Pavel A. Ivanov
43
1
4
bioRxiv

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

bioRxivAugust 5, 2019
Richard John WheelerAnthony A. Hyman
140
54
Scientific Reports

G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10

Scientific ReportsSeptember 9, 2019
Sergei AnisimovMasahiro Fujii
Scientific Reports

Segregation and potential functional impact of a rare stop-gain PABPC4L variant in familial atypical Parkinsonism

Scientific ReportsSeptember 19, 2019
Muhammad Imran AslamJakob von Engelhardt
2
1
Nature Communications

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Nature CommunicationsMay 1, 2019
Xinrui GuiDan Li
32
1
56
bioRxiv

Revisiting G3BP-S149 phosphorylation and its impact on stress granule assembly

bioRxivApril 9, 2019
Marc D PanasPaul Joseph Anderson
25
10
MBio

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

MBioJune 18, 2019
Svenja FritzlarJason M Mackenzie
26
13
BMJ Open

Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)

BMJ OpenMay 30, 2019
Jessica MandrioliAngelo Poletti
1
11
Journal of Experimental & Clinical Cancer Research : CR

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

Journal of Experimental & Clinical Cancer Research : CRSeptember 3, 2019
Yong WangDan Yue
Nature Structural & Molecular Biology

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

Nature Structural & Molecular BiologyJune 27, 2019
Qin CaoDavid S. Eisenberg
26
1
31
1
Structure

ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

StructureApril 16, 2019
Thuy P DaoCarlos A Castañeda
22
1
39
Neuron

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

NeuronJuly 6, 2019
Mark Yang FangGene W. Yeo
72
6
92
1
Cell Reports

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

Cell ReportsJune 25, 2019
Riccardo De SantisAlessandro Rosa
17
1
1
20
bioRxiv

C9orf72 dipeptide repeats inhibit UPF1-mediated RNA decay independent of stress granule formation

bioRxivApril 30, 2019
Yu SunJunjie U Guo
33
2
Brain : a Journal of Neurology

Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity

Brain : a Journal of NeurologyApril 3, 2019
Wangchao XuJin Xu
26
6
1
30
Neurobiology of Disease

Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum

Neurobiology of DiseaseOctober 15, 2019
Yalda Baradaran-HeraviJulie van der Zee
1
1
Acta Neuropathologica Communications

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

Acta Neuropathologica CommunicationsJuly 18, 2019
Laurence RenaudJean-Pierre Julien
3
1
28

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