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ALS

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Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Top 20 most recent papers
The EMBO Journal

RNA toxicity in non-coding repeat expansion disorders

The EMBO JournalNovember 13, 2019
Bart SwinnenLudo Van Den Bosch
Muscle & Nerve

Outcome measures in a cohort of ambulatory adults with spinal muscular atrophy

Muscle & NerveNovember 14, 2019
Bakri H ElsheikhStephen J Kolb
Brain : a Journal of Neurology

Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration

Brain : a Journal of NeurologyNovember 14, 2019
Tobias MollJohnathan Cooper-Knock
Human Brain Mapping

Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network

Human Brain MappingNovember 13, 2019
Elise RogerMonica Baciu
2
BMJ Open

Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic Lateral sclerosis or motor neurone Disease: the EMERALD trial

BMJ OpenNovember 11, 2019
Berzenn UrbiArman Sabet
4
Neurobiology of Aging

A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease

Neurobiology of AgingSeptember 26, 2019
Yuki KishimotoMark P. Mattson
3
1
Brain and nerve = Shinkei kenkyū no shinpo

The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Takashi Nonaka
Journal of Molecular Neuroscience : MN

Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS

Journal of Molecular Neuroscience : MNNovember 12, 2019
Shaochun ZhuMiles Trupp
Muscle & Nerve

The Utility and Practice of Electrodiagnostic Testing in the Pediatric Population: An AANEM Consensus Statement

Muscle & NerveNovember 14, 2019
Peter B KangProfessional Practice Committee of the American Association of Neuromuscular & Electrodiagnostic Medicine
bioRxiv

Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis

bioRxivNovember 14, 2019
Iddo MagenEran Hornstein
3
Brain Research

Long-term effects of the glucocorticoid receptor modulator cort 113176 in murine motoneuron degeneration

Brain ResearchNovember 11, 2019
Maria MeyerAlejandro Federico De Nicola
Brain and nerve = Shinkei kenkyū no shinpo

Impact of C9orf72 on Japanese Patients with Amytrophic Lateral Sclerosis (ALS)/Frontotemporal Dementia (FTD)

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Hiroyuki Tomiyama
Neurotoxicity Research

Motor Neurons Pathology After Chronic Exposure to MPTP in Mice

Neurotoxicity ResearchNovember 13, 2019
Giorgio VivacquaFrancesco Fornai
Muscle & Nerve

Quantitative sonographic evaluation of muscle thickness and fasciculation prevalence in healthy subjects

Muscle & NerveNovember 14, 2019
Alon AbrahamVera Bril
Muscle & Nerve

Stem-cell Based Therapies to Enhance Peripheral Nerve Regeneration

Muscle & NerveNovember 14, 2019
Carrie A KubiakStephen W P Kemp
CNS & Neurological Disorders Drug Targets

Structurally Related Edaravone Analogues: Synthesis, Antiradical, Antioxidant, and Copper-Chelating Properties

CNS & Neurological Disorders Drug TargetsNovember 13, 2019
Alexandre LeBlancMohamed Touaibia
Brain and nerve = Shinkei kenkyū no shinpo

Molecular Pathogenesis of Amyotrophic Lateral Sclerosis

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Shintaro TsuboguchiOsamu Onodera
Journal of Cell Science

In vitro compartmental system underlines the contribution of mitochondrial immobility to the ATP supply in the NMJ

Journal of Cell ScienceNovember 13, 2019
Topaz AltmanEran Perlson
Brain and nerve = Shinkei kenkyū no shinpo

The Role of Patient Registry in the Care and Therapeutic Development for Patients with Amyotrophic Lateral Sclerosis: JaCALS

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Naoki AtsutaGen Sobue
Muscle & Nerve

Reply

Muscle & NerveNovember 14, 2019
Gordon W PetersonMurray A Brandstater

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ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

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Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

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