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Alzheimer's Disease: APOE

Alzheimer's Disease: APOE diagram by Hawkes et al, PLOS One
Hawkes et al, PLOS One

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's Disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's Disease here.

Top 20 most recent papers
Acta Neuropathologica

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Acta NeuropathologicaJanuary 20, 2020
Sven J van der LeeHenne Holstege
6
Annals of Neurology

Imaging Biomarkers of Alzheimer's Disease in Multiple Sclerosis

Annals of NeurologyJanuary 24, 2020
Burcu ZeydanKejal Kantarci
Journal of Molecular and Cellular Cardiology

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

Journal of Molecular and Cellular CardiologyJanuary 24, 2020
Tasneem ArsiwalaChristian M Matter
Neurology

Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults

NeurologyJanuary 23, 2020
Eider M Arenaza-UrquijoPrashanthi Vemuri
Environmental Health : a Global Access Science Source

Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study

Environmental Health : a Global Access Science SourceJanuary 15, 2020
Gang LiuQi Sun
1
bioRxiv

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

bioRxivJanuary 14, 2020
Antonino AsaroThomas Willnow
14
PloS One

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy

PloS OneJanuary 16, 2020
Hanneke F M Rhodius-MeesterWiesje M van der Flier
2
bioRxiv

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

bioRxivJanuary 15, 2020
Man Ying WongWenjie Luo
4
Molecular and Cellular Biology

Therapeutic IDOL reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice

Molecular and Cellular BiologyJanuary 23, 2020
Jie GaoPeter Tontonoz
Gastroenterology

High Serum Levels of Cholesterol Increase Anti-tumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice

GastroenterologyJanuary 24, 2020
Wen-Hao QinHong-Yang Wang
American Journal of Epidemiology

Cohort difference in the risk of selected candidate genes on all-cause mortality at advanced ages

American Journal of EpidemiologyJanuary 24, 2020
Qihua TanKaare Christensen
Journal of Cellular and Molecular Medicine

Co-expression of glycosylated aquaporin-1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis-prone mice

Journal of Cellular and Molecular MedicineJanuary 24, 2020
Rosalinda MadonnaRaffaele De Caterina
ACS Chemical Biology

Identification of interferon receptor IFNAR2 as a novel HCV entry factor by using chemical probes

ACS Chemical BiologyJanuary 24, 2020
Jie QingZhiyong Lou
Journal of Alzheimer's Disease : JAD

Effect Modifiers of TDP-43 Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Journal of Alzheimer's Disease : JADJanuary 14, 2020
Marina BuciucKeith A Josephs
1
Neuroscience

The differential effect of treadmill exercise intensity on hippocampal soluble aβ and lipid metabolism in APP/PS1 mice

NeuroscienceJanuary 20, 2020
B ZengH L Liu
2
Acta Neuropathologica

Picalm reduction exacerbates tau pathology in a murine tauopathy model

Acta NeuropathologicaJanuary 12, 2020
Kunie AndoJean-Pierre Brion
8
1
International Journal of Clinical and Experimental Pathology

Genistein alleviates atherosclerosis in apolipoprotein E-deficient mice by interrupting the OX40/OX40L pathway

International Journal of Clinical and Experimental PathologyJanuary 15, 2020
Jiannan WeiLiming Zhang
1
Chemistry & Biodiversity

Integrating Network Pharmacology and Components analysis Study on Anti-atherosclerotic Mechanisms of Total Flavonoids of Engelhardia Roxburghiana Wall. Leaves in Mice

Chemistry & BiodiversityJanuary 17, 2020
Jie WeiGuining Wei
Pharmaceutical Medicine

Current Landscape of Late-Phase Clinical Trials for Alzheimer's Disease: Comparing Regional Variation Between Subjects in Japan and North America

Pharmaceutical MedicineJanuary 15, 2020
Masashi KikuchiKatsura Tsukamoto
1
Archives of Biochemistry and Biophysics

New variants of AADC deficiency expand the knowledge of enzymatic phenotypes

Archives of Biochemistry and BiophysicsJanuary 19, 2020
Riccardo MontioliMariarita Bertoldi

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