Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

December 22, 2020
Open Access

A 5-min Cognitive Task With Deep Learning Accurately Detects Early Alzheimer's Disease

Frontiers in Aging Neuroscience
Ibrahim AlmubarkXiong Jiang
January 12, 2021
Open Access

Advances in Drug Therapy for Alzheimer's Disease

Current Medical Science
Chuan-Cong ZhuXiao-Chuan Wang
January 7, 2021
Open Access

Alzheimer's Gone Viral: Could Herpes Simplex Virus Type-1 Be Stealing Your Memories?

Rhutuja KhokaleIvan Cancarevic
January 13, 2021

Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling

Advances in Experimental Medicine and Biology
Claudia Manzoni, Raffaele Ferrari
January 6, 2021

Hippocampal shape and asymmetry analysis by cascaded convolutional neural networks for Alzheimer's disease diagnosis

Brain Imaging and Behavior
Aojie LiAlzheimer’s Disease Neuroimaging Initiative
January 19, 2021

Recent advances in enzymeless-based electrochemical sensors to diagnose neurodegenerative diseases

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Zeyu SongXiaoying Tang
December 15, 2020

Extracellular vesicles - propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases

Journal of Cell Science
Natasha VassileffAndrew F Hill
December 18, 2020

Volumetric MRI demonstrates atrophy of the olfactory cortex in AD

Current Alzheimer Research
Majed AlOtaibiRona K Graham
January 19, 2021
Open Access

Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review

Mehak Agarwal, Safeera Khan
January 4, 2021

Curcumin-Pluronic Nanoparticles: A Theranostic Nanoformulation for Alzheimer's Disease

Critical Reviews in Biomedical Engineering
Ajay SinghParas N Prasad
January 14, 2021
Open Access

ApoE4 attenuates cortical neuronal activity and impairs memory in young apoE4 rats

BioRxiv : the Preprint Server for Biology
I. Har-PazAnan Moran
January 3, 2021

Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

International Journal of Geriatric Psychiatry
L Carazo-BarriosN García-Casares
January 8, 2021
Open Access

The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis

International Journal of Molecular Sciences
Simran RastogiSaroj Kumar
December 31, 2020
Open Access

A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages

Journal of Personalized Medicine
Giulia AbateDaniela Uberti
January 5, 2021
Open Access

Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer's disease.

Translational Neurodegeneration
Kok Pin NgDominantly Inherited Alzheimer Network
January 19, 2021
Open Access

Tau in the Pathophysiology of Parkinson's Disease

Journal of Molecular Neuroscience : MN
Lina PanZhentao Zhang
January 21, 2021
Open Access

A Whole-Brain Functional Connectivity Model of Alzheimers Disease Pathology

MedRxiv : the Preprint Server for Health Sciences
Ruchika Shaurya PrakashD. W. Scharre

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.


TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2021 Meta ULC. All rights reserved