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Alzheimer's Disease: Genetics

Alzheimer's Disease: Genetics diagram by Swaminathan et al, Wikimedia
Swaminathan et al, Wikimedia

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Top 20 most recent papers
Nature Medicine

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

Nature MedicineJanuary 15, 2020
Yingyue ZhouMarco Colonna
44
1
Brain, Behavior, and Immunity

Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults

Brain, Behavior, and ImmunityJanuary 15, 2020
Keenan A WalkerJeremy Walston
2
bioRxiv

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

bioRxivJanuary 15, 2020
Man Ying WongWenjie Luo
3
Neurobiology of Disease

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

Neurobiology of DiseaseJanuary 14, 2020
Tomohiro ImamuraJun-Ichi Kira
Molecular and Cellular Biology

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer's Disease Model Mice

Molecular and Cellular BiologyJanuary 15, 2020
Akira UrunoMasayuki Yamamoto
2
bioRxiv

A Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation

bioRxivJanuary 15, 2020
Yuanhui maJohn Robert Yates
1
bioRxiv

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

bioRxivJanuary 14, 2020
Antonino AsaroThomas Willnow
13
Nature Communications

Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect

Nature CommunicationsJanuary 12, 2020
Guilin PiJian-Zhi Wang
Journal of Proteomics

Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects

Journal of ProteomicsJanuary 14, 2020
Ayse L MindikogluSung Yun Jung
12
BMC Biology

Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

BMC BiologyJanuary 16, 2020
Kyerl ParkJeehyun Kwag
3
The Journal of Physical Chemistry. B

Stability of Aβ11-40 Trimers with Parallel and Antiparallel β-Sheet Organizations in a Membrane-Mimicking Environment by Replica Exchange Molecular Dynamics Simulation

The Journal of Physical Chemistry. BJanuary 15, 2020
Son Tung NgoPhilippe Derreumaux
1
Movement Disorders : Official Journal of the Movement Disorder Society

CLU rs11136000 promotes early cognitive decline in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder SocietyJanuary 14, 2020
Frederic SampedroJaime Kulisevsky
5
Journal of Alzheimer's Disease : JAD

Cortical Superficial Siderosis: A Descriptive Analysis in a Memory Clinic Population

Journal of Alzheimer's Disease : JADJanuary 14, 2020
Aline MendesGabriel Gold
1
Journal of Psychiatric Research

White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease

Journal of Psychiatric ResearchJanuary 14, 2020
Stella M SánchezMirta F Villarreal
8
Journal of Alzheimer's Disease : JAD

Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy

Journal of Alzheimer's Disease : JADJanuary 14, 2020
Chenjia XuSujuan Gao
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryJanuary 16, 2020
Jenny M TamXudong Huang
The International Journal of Neuroscience

Activating Transcription Factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice

The International Journal of NeuroscienceJanuary 14, 2020
Yayun DuXiaopan Wu
1
Neurobiology of Disease

APOE alters glucose flux through central carbon pathways in astrocytes

Neurobiology of DiseaseJanuary 14, 2020
Holden C WilliamsLance A Johnson
22
Neurochemistry International

Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling

Neurochemistry InternationalJanuary 14, 2020
Qiong PanQiuyun Tu
1
Journal of Alzheimer's Disease : JAD

Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling

Journal of Alzheimer's Disease : JADJanuary 14, 2020
Sumana R ChintapaludiGareth R Howell

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