Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

June 20, 2021

Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain.

Biochemical and Biophysical Research Communications
Jae Woong ByeonHyun-Seok Park
June 19, 2021

COVID-19-related neuropathology and microglial activation in elderly with and without dementia.

Brain Pathology
Tino Emanuele PoloniMauro Ceroni
June 18, 2021

Alzheimer's Disease Genetics: A Dampened Microglial Response?

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Zena K Chatila, Elizabeth M Bradshaw
June 18, 2021
Open Access

CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.

Frontiers in Immunology
Vanessa AiresEva Harde
June 17, 2021
Preprint
Open Access

Amyloid-beta, p-tau, and reactive microglia load are correlates of MRI cortical atrophy in Alzheimer's disease

BioRxiv : the Preprint Server for Biology
Irene FrigerioL. E. Jonkman
June 17, 2021

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.

Neuron
Deepti LallRobert H Baloh
June 15, 2021

Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys.

Brain : a Journal of Neurology
Akash G PatelHenrieta Scholtzova
June 15, 2021
Open Access

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo.

Life Science Alliance
Karen N McFarlandTodd E Golde
June 15, 2021
Open Access

Sorafenib Modulates the LPS- and Aβ-Induced Neuroinflammatory Response in Cells, Wild-Type Mice, and 5xFAD Mice.

Frontiers in Immunology
Jieun KimHyang-Sook Hoe
June 15, 2021
Review
Open Access

Nanoparticles: A Hope for the Treatment of Inflammation in CNS.

Frontiers in Pharmacology
Feng-Dan ZhuAn-Guo Wu
June 15, 2021
Review
Open Access

Role of P2X7 Receptors in Immune Responses During Neurodegeneration.

Frontiers in Cellular Neuroscience
Ágatha Oliveira-GiacomelliHenning Ulrich
June 15, 2021

TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice.

Journal of Alzheimer's Disease : JAD
Milan StoiljkovicMihály Hajós
June 14, 2021

Ficus deltoidea: Potential Inhibitor of Pro-Inflammatory Mediators in Lipopolysaccharide-Induced Activation of Microglial Cells.

Journal of Ethnopharmacology
Siti Zaidathul Iman ZolkifflyMuhammad Zulfadli Mehat
June 13, 2021

Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease.

European Journal of Medicinal Chemistry
Zhiyu WangDonald F Weaver
June 12, 2021
Open Access

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.

Journal of Neuroinflammation
Xiao-Ying SunRui-Tian Liu
June 12, 2021
Open Access

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease.

Communications Biology
Marie-Victoire Guillot-SestierMarina A Lynch

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2021 Meta ULC. All rights reserved
/feed-previews/alzheimers-disease-microglia/1e9b60bb-6b0e-4f3e-8696-680eb80782ac