Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

March 8, 2016
Open Access

Potential contribution of the Alzheimer's disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Lior GreenbaumMichal Schnaider Beeri
June 13, 2016
Open Access

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

Neurobiology of Aging
Celeste SassiJohn Hardy
May 23, 2017
Preprint
Open Access

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease

BioRxiv : the Preprint Server for Biology
K.-l. HuangA L
August 16, 2016
Open Access

The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits

Human Molecular Genetics
Yuji KajiwaraJoseph D Buxbaum
June 1, 2016
Open Access

MS4A6A genotypes are associated with the atrophy rates of Alzheimer's disease related brain structures

Oncotarget
Jing Ma Alzheimer's Disease Neuroimaging Initiative
July 1, 2015
Open Access

Alzheimer's loci: epigenetic associations and interaction with genetic factors

Annals of Clinical and Translational Neurology
Lori B ChibnikPhilip L De Jager
April 12, 2016
Open Access

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding

Neurology. Genetics
Andreas LazarisAlzheimer's Disease Neuroimaging Initiative
March 1, 2016

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

Neurobiology of Aging
Leslie M RamirezLiana G Apostolova
April 24, 2018
Open Access

One for all and all for One: Improving replication of genetic studies through network diffusion

PLoS Genetics
Daniel LancourSimon Kasif
August 16, 2019
Open Access

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Science Translational Medicine
Yuetiva DemingCarlos Cruchaga
June 15, 2015
Review
Open Access

The epigenetics of aging and neurodegeneration

Progress in Neurobiology
Roy LardenoijeBart P F Rutten
February 6, 2018
Review

Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase

Reviews in the Neurosciences
Harikesh DubeyArunabha Ray
May 10, 2017

Validating GWAS Variants from Microglial Genes Implicated in Alzheimer's Disease

Journal of Molecular Neuroscience : MN
Lígia Ramos Dos SantosFlavia de Paula
July 6, 2019
Preprint
Open Access

Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms

BioRxiv : the Preprint Server for Biology
Gloriia NovikovaAlison M Goate
November 25, 2016

Computational Screening and Exploration of Disease-Associated Genes in Alzheimer's Disease

Journal of Cellular Biochemistry
Salma JamalAbhinav Grover
May 3, 2016
Review
Open Access

Genomics of Alzheimer Disease: A Review

JAMA Neurology
Roger N RosenbergWeiming Xia
December 2, 2015
Open Access

Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci?

PloS One
Robert C BarberTexas Alzheimer’s Research and Care Consortium
November 19, 2018
Open Access

Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs

Neurobiology of Aging
Yuriko KatsumataDavid W Fardo
June 24, 2016

APOE and MS4A6A interact with GnRH signaling in Alzheimer's disease: Enrichment of epistatic effects

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Alejandro CáceresJuan R González

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