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Alzheimer's Disease: MS4A

Alzheimer's Disease: MS4A diagram by Atthapon Raksthaput, Shutterstock
Atthapon Raksthaput, Shutterstock

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

Top 20 most recent papers
bioRxiv

A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer's disease

bioRxivFebruary 26, 2017
Kuan-lin HuangAlison M Goate
21
3
PloS One

Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review

PloS OneSeptember 4, 2015
Eugene Y H TangBlossom C M Stephan
13
1
116
Annals of Neurology

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

Annals of NeurologyJune 24, 2015
Badri VardarajanRichard Mayeux
13
1
112
Current Opinion in Neurobiology

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

Current Opinion in NeurobiologyOctober 31, 2015
Claudio Villegas-LlerenaJennifer M Pocock
3
1
276
Molecular Neurodegeneration

TREM2 in CNS homeostasis and neurodegenerative disease

Molecular NeurodegenerationSeptember 5, 2015
Meghan M PainterGuojun Bu
4
156
Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials

Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationMarch 28, 2017
Michael W WeinerAlzheimer's Disease Neuroimaging Initiative
9
1
279
bioRxiv

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

bioRxivJune 20, 2018
Yuetiva DemingCarlos Cruchaga
17
75
Annual Review of Neuroscience

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

Annual Review of NeuroscienceApril 7, 2016
Carlo Sala Frigerio, Bart De Strooper
6
4
1
233
JAMA Neurology

Genomics of Alzheimer Disease: A Review

JAMA NeurologyMay 3, 2016
Roger N RosenbergWeiming Xia
67
12
181
Annals of Clinical and Translational Neurology

Alzheimer's loci: epigenetic associations and interaction with genetic factors

Annals of Clinical and Translational NeurologyJuly 1, 2015
Lori B ChibnikPhilip L De Jager
3
1
48
Redox Biology

A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease

Redox BiologyNovember 28, 2017
Sarah E LacherMatthew Slattery
3
1
11
Neurobiology of Aging

Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

Neurobiology of AgingMarch 1, 2016
Leslie M RamirezLiana G Apostolova
10
4
2
47
Neurobiology of Aging

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

Neurobiology of AgingJune 13, 2016
Celeste SassiJohn Hardy
9
1
1
80
Science Translational Medicine

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Science Translational MedicineAugust 16, 2019
Yuetiva DemingCarlos Cruchaga
205
98
1
93
bioRxiv

Alzheimer's Genetic Risk Score linked to Incident Mild Behavioral Impairment

bioRxivOctober 10, 2017
Shea J AndrewsMoyra Mortby
3
5
bioRxiv

Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms

bioRxivJuly 6, 2019
Gloriia NovikovaAlison M Goate
30
15
1
PloS One

Functional annotation of Alzheimer's disease associated loci revealed by GWASs

PloS OneJune 27, 2017
Zengpeng HanQingyang Huang
4
1
51
Age

Gene-based aggregate SNP associations between candidate AD genes and cognitive decline

AgeMarch 24, 2016
Jasmine NettiksimmonsKristine Yaffe
3
1
53
Brain Research

Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease

Brain ResearchOctober 16, 2015
Sarah E Sullivan, Tracy L Young-Pearse
2
1
111
Oncotarget

MS4A6A genotypes are associated with the atrophy rates of Alzheimer's disease related brain structures

OncotargetJune 1, 2016
Jing MaAlzheimer's Disease Neuroimaging Initiative
1
1
15

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