Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

July 12, 2020
Review

Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and 1 H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review

Academic Radiology
Albert Dayor PierssonSubapriya Suppiah
July 10, 2020
Review

Understanding cause and effect in Alzheimer's pathophysiology: implications for clinical trials

Neuropathology and Applied Neurobiology
Delphine Boche, James A R Nicoll
July 14, 2020
Open Access

A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

Frontiers in Cellular Neuroscience
Mercedes A Hernández-SapiénsAlejandro A Canales-Aguirre
July 6, 2020

In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy

Neurobiology of Aging
Anna M BarronMakoto Higuchi
July 6, 2020

One stop shop: Flortaucipir PET differentiates amyloid positive and negative forms of neurodegenerative diseases

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jochen HammesThilo van Eimeren
July 10, 2020

Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease

Human Brain Mapping
Sebastian G PopescuAlzheimer's Disease Neuroimaging Initiative
July 14, 2020

Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy

Upsala Journal of Medical Sciences
Mehrnaz HaghiSeyed Morteza Najibi
July 6, 2020

Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations

Biophysical Chemistry
Phuong H Nguyen, Philippe Derreumaux
July 4, 2020

Neuropsychological tests are useful for predicting comorbidities of idiopathic normal-pressure hydrocephalus

Acta Neurologica Scandinavica
Chihiro KamoharaMasakazu Miyajima
July 3, 2020
Open Access

Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Acta Neuropathologica Communications
Si Jie TangStephen M Strittmatter
July 14, 2020

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability

ELife
Yuliya VoskobiynykErik D Roberson
July 11, 2020

18 F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ryuichi HaradaNobuyuki Okamura
July 8, 2020
Open Access

β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline

Communications Biology
Tyler C HammondAi-Ling Lin
July 9, 2020
Open Access

Synonymous variants associated with Alzheimer disease in multiplex families

Neurology. Genetics
Min TangChristiane Reitz

Sign up to follow this feed and discover related papers.

Related Feeds

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/alzheimers-disease-tau-tdp-43/bf65cd8a-8d73-4c60-b180-464a6d7ad182