Alzheimer's Disease: Transcription

Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.

July 27, 2020

A chemical biology approach to identifying molecular pathways associated with aging

GeroScience
Antonio CurraisDavid Schubert
July 29, 2020

Self-reported experiences of discrimination in older black adults are associated with insula functional connectivity

Brain Imaging and Behavior
S Duke HanLisa L Barnes
August 1, 2020
Review
Open Access

Intron Retention as a Mode for RNA-Seq Data Analysis

Frontiers in Genetics
Jian-Tao ZhengHong-Dong Li
July 28, 2020
Preprint
Open Access

Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology.

BioRxiv : the Preprint Server for Biology
P. BathiniLavinia Alberi
July 29, 2020

Person-specific contributions of brain pathologies to progressive parkinsonism in older adults

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Aron S BuchmanDavid A Bennett
August 4, 2020

Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

Neurobiology of Aging
Danielle L BrokawPaul D Coleman
August 5, 2020
Open Access

Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity

EMBO Reports
Vittoria MataforaAngela Bachi
July 28, 2020
Open Access

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

Journal of Neuroinflammation
Xavier TaylorCristian A Lasagna-Reeves
July 29, 2020

Cyclic Nucleotides Signaling and Phosphodiesterase Inhibition: Defying Alzheimer's Disease

Current Drug Targets
Vivek Kumar SharmaShareen Singh
July 25, 2020
Open Access

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Molecular Neurodegeneration
Nicholas F FitzRadosveta Koldamova
August 2, 2020
Open Access

MicroRNA Expression Signature in Mild Cognitive Impairment Due to Alzheimer's Disease

Molecular Neurobiology
Bruna De FeliceCinzia Coppola
August 5, 2020
Preprint

Epitomic analysis of the specificity of conformation-dependent, anti-aβ amyloid monoclonal antibodies

BioRxiv : the Preprint Server for Biology
J. M. Reyes-RuizCharles G Glabe
July 24, 2020
Review
Open Access

Brain cell somatic gene recombination and its phylogenetic foundations

The Journal of Biological Chemistry
Gwendolyn Kaeser, Jerold Chun
August 1, 2020
Preprint
Open Access

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

BioRxiv : the Preprint Server for Biology
Becky Catherine CarlyleS. E. Arnold
July 23, 2020
Open Access

Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging

Frontiers in Aging Neuroscience
Qirui ZhangXin Li
July 25, 2020
Preprint
Open Access

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

BioRxiv : the Preprint Server for Biology
F. A. SayedLi Gan
July 28, 2020
Review
Open Access

Somatic mutations in neurodegeneration: An update

Neurobiology of Disease
Christos Proukakis
August 1, 2020

Association between DNA methylation levels in brain tissue and late-life depression in community-based participants

Translational Psychiatry
Anke HülsAliza P Wingo

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