AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

July 7, 2020

Familial leukemia due to germline RUNX1 mutations: lessons learned from two decades of research and unsolved problems

[Rinshō ketsueki] The Japanese journal of clinical hematology
Motomi Osato, Akiko Nambu
July 6, 2020
Open Access

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Nature Communications
Yi ZhangTatiana G Kutateladze
July 6, 2020

E3 ligase SCFSKP2 ubiquitinates and degrades tumor suppressor C/EBPα in acute myeloid leukemia

Life Sciences
Gatha ThackerArun Kumar Trivedi
July 6, 2020
Preprint
Open Access

TLR7 ligation augments haematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signalling and enhanced differentiation

BioRxiv : the Preprint Server for Biology
O. C. PenaElspeth M Payne
July 4, 2020

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions

Cell Systems
Leanna MorinishiSteven J Altschuler
July 8, 2020

Targeting CD70 in acute myeloid leukaemia

Nature Reviews. Drug Discovery
Sarah Crunkhorn
July 9, 2020

Natural History of Renal Angiomyolipoma Favors Surveillance as an Initial Approach

European Urology Focus
Gregory J NasonAntonio Finelli
July 4, 2020

Rubbing Out Leukemia Stem Cells by Erasing the Eraser

Cell Stem Cell
Yuanming ChengMichael G Kharas
July 9, 2020

The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial

International Journal of Cancer. Journal International Du Cancer
Tobias RoiderSascha Dietrich

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