Amyloid Beta Deposition & Degradation

Amyloid beta is neurotoxic and a major component of plaques in Alzheimer’s disease. Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Breakdown of amyloid is important to prevent the development of Alzheimer’s disease. Here is the latest research on amyloid beta deposition and degradation.

September 7, 2020

Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice

Experimental Brain Research
Jie LiYi He
September 13, 2020

Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Yuemang YaoKurt R Brunden
September 2, 2020
Open Access

Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice

Journal of Neuroinflammation
Dan LiuHui Zhou
September 4, 2020

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

Nature
Ji-Yeun HurYue-Ming Li
September 25, 2020
Review
Open Access

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

Cells
Noemi Esteras, Andrey Y Abramov
September 14, 2020

Longitudinal Cognitive and Biomarker Measurements Support a Unidirectional Pathway in Alzheimer's Disease Pathophysiology

Biological Psychiatry
Tengfei GuoAlzheimer’s Disease Neuroimaging Initiative
September 22, 2020
Preprint

Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse model

BioRxiv : the Preprint Server for Biology
K. A. ClaytonTsuneya Ikezu
September 15, 2020

Traumatic Injury Reduces Amyloid Plaque Burden in the Transgenic 5xFAD Alzheimer's Mouse Spinal Cord

Journal of Alzheimer's Disease : JAD
Tak-Ho ChuPeter K Stys
September 20, 2020

Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments

Hormones and Behavior
Elizabeth T NguyenMatia B Solomon
September 4, 2020
Open Access

Hippocampal alterations in glutamatergic signaling during amyloid progression in AβPP/PS1 mice

Scientific Reports
Kevin N HascupErin R Hascup
September 11, 2020
Open Access

Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Molecular Neurodegeneration
Joanna E PankiewiczMartin J Sadowski
September 15, 2020

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders

Journal of Alzheimer's Disease : JAD
Matthew John MoldChristopher Exley
September 12, 2020
Open Access

Somatostatin, an In Vivo Binder to Aβ Oligomers, Binds to βPFOAβ(1-42) Tetramer

ACS Chemical Neuroscience
Eduard PuigNatalia Carulla
September 16, 2020
Review

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease

Neurochemical Research
Yidan ZhangGuofeng Yang
September 15, 2020

Anticoagulants for Treatment of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Klaus Grossmann

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