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Amyloid Beta Deposition & Degradation

Amyloid Beta Deposition & Degradation diagram by

Amyloid beta is neurotoxic and a major component of plaques in Alzheimer’s disease. Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Breakdown of amyloid is important to prevent the development of Alzheimer’s disease. Here is the latest research on amyloid beta deposition and degradation.

Top 20 most recent papers
bioRxiv

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

bioRxivJanuary 15, 2020
Man Ying WongWenjie Luo
4
Scientific Reports

Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons

Scientific ReportsJanuary 19, 2020
Tugce Munise SatirPetra Bergström
2
1
1
Neuron

Aβ Puts the Alpha in Synuclein

NeuronJanuary 24, 2020
Casey Cook, Leonard Petrucelli
12
Annals of Neurology

Imaging Biomarkers of Alzheimer's Disease in Multiple Sclerosis

Annals of NeurologyJanuary 24, 2020
Burcu ZeydanKejal Kantarci
10
bioRxiv

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

bioRxivJanuary 27, 2020
Michela DeleidiCarlo Viscomi
bioRxiv

Multimodal magnetic resonance imaging predicts regional amyloid-β burden in the brain

bioRxivJanuary 18, 2020
Anusha Alathur RangarajanHoward Aizenstein
3
American Journal of Nuclear Medicine and Molecular Imaging

Reduction in amyloid β deposition on 18 F-florbetapir positron emission tomography with correction of cerebral hypoperfusion after endarterectomy for carotid stenosis

American Journal of Nuclear Medicine and Molecular ImagingJanuary 25, 2020
Kuniaki OgasawaraYoshitaka Kubo
Behavioural Brain Research

Hippocampal overexpression of SGK1 ameliorates spatial memory, rescues Aβ pathology and actin cytoskeleton polymerization in middle-aged APP/PS1 mice

Behavioural Brain ResearchJanuary 26, 2020
Biyao LianChengjun Zhao
3
International Journal of Molecular Sciences

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer's Therapeutics

International Journal of Molecular SciencesJanuary 25, 2020
Varnavas D MouchlisAntreas Afantitis
Molecular Neurodegeneration

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Molecular NeurodegenerationJanuary 23, 2020
Jian-Guo LiDomenico Praticò
8
6
Nature Communications

FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease

Nature CommunicationsJanuary 23, 2020
Tingxiang YanXinglong Wang
19
12
1
Scientific Reports

Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease

Scientific ReportsJanuary 25, 2020
Udaysankar ChockanathanKrishnan Padmanabhan
Journal of Alzheimer's Disease : JAD

Resistance Exercise Decreases Amyloid Load and Modulates Inflammatory Responses in the APP/PS1 Mouse Model for Alzheimer's Disease

Journal of Alzheimer's Disease : JADJanuary 21, 2020
Debora HashiguchiBeatriz Monteiro Longo
1
Biochemistry

Direct Interaction between the β-Amyloid Core and Tau Facilitates Cross-Seeding: A Novel Target for Therapeutic Intervention

BiochemistryJanuary 17, 2020
Timir Tripathi, Heena Khan
1
Biochemical Pharmacology

Using Curcumin to Turn the Innate Immune System Against Cancer

Biochemical PharmacologyJanuary 29, 2020
Sumit MukherjeeProbal Banerjee
ACS Applied Materials & Interfaces

Near-Infrared Responsive Dopamine/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid β Nucleation, Propagation, and Ameliorate Neuronal Functions

ACS Applied Materials & InterfacesJanuary 28, 2020
Anup K SrivastavaSurajit Karmakar
1
Experimental Neurology

Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca2+ /CaMKII/CREB signaling pathway

Experimental NeurologyJanuary 29, 2020
Chen ChenHung Wing Li
Journal of Alzheimer's Disease : JAD

Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in J20 Mice

Journal of Alzheimer's Disease : JADJanuary 28, 2020
Mona AbdelhamidMakoto Michikawa
2
Brain and Behavior

Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review

Brain and BehaviorJanuary 29, 2020
Cheng-Hsuan LiChin-Hsien Lin
bioRxiv

Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer′s disease model

bioRxivJanuary 25, 2020
Youngsun LeeDong Soo Lee

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