Amyloid Beta Deposition & Degradation

Amyloid beta is a peptide that is a major component of plaques in Alzheimer’s disease (AD). Accumulation induces neurotoxic effects including oxidative damage and mitochondrial dysfunction. Amyliod plaques are being studied as a drug target in the treatment of AD. Here is the latest research on amyloid beta deposition and degradation.

October 16, 2021

Artemether Attenuates Aβ25-35-Induced Cognitive Impairments by Downregulating Aβ, BACE1, mTOR and Tau Proteins.

Clinical Laboratory
Hong-Juan LiChuanhai Cao
October 13, 2021

Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression.

Glia
Caden M HenningfieldKim N. Green
October 13, 2021

Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet.

GeroScience
Rita Cervera-JuanesHenryk F Urbanski
October 13, 2021
Open Access

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.

Acta Neuropathologica Communications
Suzanne LamMarc Dhenain
October 13, 2021
Review
Open Access

An Overview of Several Inhibitors for Alzheimer's Disease: Characterization and Failure.

International Journal of Molecular Sciences
Subramanian BoopathiRamón Garduño-Juárez
October 13, 2021
Review
Open Access

Cofilin Signaling in the CNS Physiology and Neurodegeneration.

International Journal of Molecular Sciences
Jannatun Nayem NammeHirohide Takebayashi
October 13, 2021

Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice.

The Journal of Nutrition
Zhongbao ZhangZhongyi Wu
October 9, 2021

Isolation and Characterization of Heparan Sulfate Containing Amyloid Precursor Protein Degradation Products.

Methods in Molecular Biology
Katrin Mani
October 8, 2021

Neuroprotective Effect of Danggui Shaoyao San via the Mitophagy-Apoptosis Pathway in a Rat Model of Alzheimer's Disease.

Evidence-based Complementary and Alternative Medicine : ECAM
Zhenyan SongShaowu Cheng
October 7, 2021

Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals.

Brain Communications
Silvia IngalaAnouk den Braber
October 7, 2021

Effects and mechanisms of natural products on Alzheimer's disease.

Critical Reviews in Food Science and Nutrition
Zhijun YangHui-Lian Zhu
October 5, 2021
Review

Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Aisha SiddiquiYatinesh Kumari
October 4, 2021

Chitosan-coated Selenium nanoparticles enhance the efficiency of stem cells in the neuroprotection of streptozotocin-induced neurotoxicity in male rats.

The International Journal of Biochemistry & Cell Biology
Sara Soleimani AslSiamak Shahidi
October 3, 2021

Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.

The Journal of Biological Chemistry
He LiuJiri G Safar
October 2, 2021
Preprint
Open Access

Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

BioRxiv : the Preprint Server for Biology
D. I. JavonilloF. M. LaFerla
October 2, 2021

Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia.

Neurotoxicity Research
Sally KellinyXin-Fu Zhou

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