Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

December 19, 2020
Open Access

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Nature Medicine
Jordan R BarrettOxford COVID Vaccine Trial Group
September 15, 2020
Open Access

Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells

Frontiers in Immunology
Chen ZhuMarielle Chiron
January 5, 2021

Diagnostic Utility of C4d by Direct Immunofluorescence in Bullous Pemphigoid

The American Journal of Dermatopathology
Jeffrey DammanGilles F H Diercks
December 29, 2020
Open Access

Effect of red seaweed sulfated galactans on initial steps of complement activation in vitro

Carbohydrate Polymers
E V SokolovaI M Yermak
November 3, 2020
Open Access

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology
Tertia D Purves-TysonCynthia Shannon Weickert
September 19, 2020
Open Access

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

Alessandro RambaldiGregory Demopulos
January 15, 2021

Complement-5 inhibition deters progression of fulminant hepatitis to acute liver failure in murine models

Cellular and Molecular Gastroenterology and Hepatology
Jiro KusakabeShinji Uemoto
October 12, 2020
Open Access

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

BioRxiv : the Preprint Server for Biology
A. KumarSyed M Faisal
January 12, 2021

Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein IgG associated disorder: A comprehensive neuro-ophthalmic review

Clinical & Experimental Ophthalmology
Jaya SharmaHelen V Danesh-Meyer
November 22, 2020

Histopathology of Human Donor Spleen Utilized as a Desensitization Tool Before Intestinal Transplantation

American Journal of Clinical Pathology
Sujata GaitondeSuman Setty
October 18, 2020
Open Access

Structure, Function, and Therapeutic Use of IgM Antibodies

Bruce A KeytMarvin S Peterson
September 18, 2020
Open Access

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy

MedRxiv : the Preprint Server for Health Sciences
H. NatarajanMargaret E Ackerman
January 8, 2021
Open Access

Multi-organ complement deposition in COVID-19 patients

MedRxiv : the Preprint Server for Health Sciences
Paolo MacorFrancesco Tedesco
October 1, 2020
Open Access

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy

MedRxiv : the Preprint Server for Health Sciences
Harini NatarajanMargaret E Ackerman
November 8, 2020

The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system

Yoichi Sutoh, Masanori Kasahara

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