Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

December 19, 2020
Open Access

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Nature Medicine
Jordan R BarrettOxford COVID Vaccine Trial Group
September 15, 2020
Open Access

Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells

Frontiers in Immunology
Chen ZhuMarielle Chiron
January 5, 2021

Diagnostic Utility of C4d by Direct Immunofluorescence in Bullous Pemphigoid

The American Journal of Dermatopathology
Jeffrey DammanGilles F H Diercks
December 29, 2020
Open Access

Effect of red seaweed sulfated galactans on initial steps of complement activation in vitro

Carbohydrate Polymers
E V SokolovaI M Yermak
November 3, 2020
Open Access

Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia

Frontiers in Immunology
Tertia D Purves-TysonCynthia Shannon Weickert
September 19, 2020
Open Access

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

Immunobiology
Alessandro RambaldiGregory Demopulos
January 15, 2021

Complement-5 inhibition deters progression of fulminant hepatitis to acute liver failure in murine models

Cellular and Molecular Gastroenterology and Hepatology
Jiro KusakabeShinji Uemoto
October 12, 2020
Preprint
Open Access

Leptospira surface protein LigA plays a multifaceted role in modulating the host innate immune response

BioRxiv : the Preprint Server for Biology
A. KumarSyed M Faisal
January 12, 2021
Review

Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein IgG associated disorder: A comprehensive neuro-ophthalmic review

Clinical & Experimental Ophthalmology
Jaya SharmaHelen V Danesh-Meyer
November 22, 2020

Histopathology of Human Donor Spleen Utilized as a Desensitization Tool Before Intestinal Transplantation

American Journal of Clinical Pathology
Sujata GaitondeSuman Setty
October 18, 2020
Review
Open Access

Structure, Function, and Therapeutic Use of IgM Antibodies

Antibodies
Bruce A KeytMarvin S Peterson
September 18, 2020
Preprint
Open Access

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy

MedRxiv : the Preprint Server for Health Sciences
H. NatarajanMargaret E Ackerman
January 8, 2021
Preprint
Open Access

Multi-organ complement deposition in COVID-19 patients

MedRxiv : the Preprint Server for Health Sciences
Paolo MacorFrancesco Tedesco
October 1, 2020
Preprint
Open Access

SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy

MedRxiv : the Preprint Server for Health Sciences
Harini NatarajanMargaret E Ackerman
November 8, 2020
Review

The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system

Immunogenetics
Yoichi Sutoh, Masanori Kasahara

Sign up to follow this feed and discover related papers.

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B cell Tolerance

B cell tolerance is maintained through mechanisms that can reversibly or irreversibly silence autoreactive B lymphocytes. Here is the latest research.

© 2021 Meta ULC. All rights reserved
/feed-previews/antibodies-complement-activation/f4145618-ae60-4266-aad5-98861d411064