Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


April 22, 2020

Physicochemical determinants of antibody-protein interactions

Advances in Protein Chemistry and Structural Biology
Murat KaradagSibel Kalyoncu
February 20, 2020

Monoclonal antibodies: A prospective and retrospective view

Current Medicinal Chemistry
Jwala SivaccumarMenotti Ruvo
April 19, 2020
ReviewOpen Access

Antibody development for preventing the human respiratory syncytial virus pathology

Molecular Medicine
Jorge A SotoAlexis M Kalergis
May 21, 2020

Portable solid sensor supported in nylon for silver ion determination: testing its liberation as biocide

Analytical and Bioanalytical Chemistry
Sara Bocanegra-RodríguezPilar Campíns-Falcó
April 5, 2020
ReviewOpen Access

Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens

Antibiotics
Daniel V Zurawski, Molly K McLendon
May 2, 2020
ReviewOpen Access

A Review of Deep Learning Methods for Antibodies

Antibodies
Jordan GravesMonica Berrondo
February 3, 2020
Review

Critical evaluation of a possible role of HLA epitope matching in kidney transplantation

Transplantation Reviews
Gizem Kumru SahinCaner Süsal
March 25, 2020

Heliotropium thermophilum , an extreme heat tolerant species, promises plants about adaptation to high soil temperature conditions

Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology
Kamil OzturkAsım Kadioglu
February 28, 2020

Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Jiahui SunXueqiong Zhang
May 18, 2020

Intensive therapy with gastropodan hemocyanins increases their antitumor properties in murine model of colon carcinoma

International Immunopharmacology
Emiliya StoyanovaAndrey Tchorbanov
February 29, 2020
Open Access

Characterization of a Species E Adenovirus Vector as a Zika virus vaccine

Scientific Reports
Brianna L BullardEric A Weaver
February 15, 2020

Synthesis of highly fluorescent and water soluble graphene quantum dots for detection of heavy metal ions in aqueous media

Environmental Science and Pollution Research International
Savan K RajVaibhav Kulshrestha
February 25, 2020

Heteromorphic Sex Chromosomes and Their DNA Content in Fish: An Insight through Satellite DNA Accumulation in Megaleporinus elongatus

Cytogenetic and Genome Research
Carolina Crepaldi, Patricia P Parise-Maltempi

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Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B cell Tolerance

B cell tolerance is maintained through mechanisms that can reversibly or irreversibly silence autoreactive B lymphocytes. Here is the latest research.

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