Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.

July 1, 2020
Open Access

Long-term safety and efficacy results from the phase 3b, open-label, multicentre Continuation study of rurioctocog alfa pegol for prophylaxis in previously treated patients with severe haemophilia A

Haemophilia : the Official Journal of the World Federation of Hemophilia
Pratima ChowdarySrilatha Tangada
July 7, 2020
Open Access

Early subclinical tubulitis and interstitial inflammation in kidney transplantation have adverse clinical implications

Kidney International
Rajil B MehtaSundaram Hariharan
May 21, 2020

Portable solid sensor supported in nylon for silver ion determination: testing its liberation as biocide

Analytical and Bioanalytical Chemistry
Sara Bocanegra-RodríguezPilar Campíns-Falcó
June 25, 2020
Open Access

Shielding and Beyond: The Roles of Glycans in SARS-CoV-2 Spike Protein

BioRxiv : the Preprint Server for Biology
Lorenzo CasalinoRommie E Amaro
June 20, 2020
Open Access

Private Antibody Repertoires Are Public

BioRxiv : the Preprint Server for Biology
R. Arora, Ramy Arnaout
July 9, 2020
Open Access

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

BioRxiv : the Preprint Server for Biology
Priyamvada AcharyaBarton F Haynes
August 29, 2020
Open Access

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Nature Biotechnology
Jeffrey D WhitmanAlexander Marson
May 18, 2020

Intensive therapy with gastropodan hemocyanins increases their antitumor properties in murine model of colon carcinoma

International Immunopharmacology
Emiliya StoyanovaAndrey Tchorbanov
July 19, 2020

Antibody development and property analysis of RhBST2 for accurate cell biological and viral research

Protein Expression and Purification
Meng QuXianghui Yu
June 2, 2020
Open Access

Prevalence of SARS-CoV-2 Antibodies Among Healthcare Workers at a Tertiary Academic Hospital in New York City

MedRxiv : the Preprint Server for Health Sciences
Mayce MansourA. Wajnberg
July 30, 2020

Understanding microcystin-LR antibody binding interactions using in silico docking and in vitro mutagenesis

Protein Engineering, Design & Selection : PEDS
Daniel A McPartlinRichard J O'Kennedy
July 2, 2020
Open Access

Sensitive detection of SARS-CoV-2-specific-antibodies in dried blood spot samples

MedRxiv : the Preprint Server for Health Sciences
G. L. MorleyMatthew K O'Shea
June 18, 2020
Open Access

Aptamer-Based Biosensors for Environmental Monitoring

Frontiers in Chemistry
Erin M McConnellYingfu Li
May 23, 2020

Heat shock factor 5 is essential for spermatogenesis in mice: Detected by a new monoclonal antibody

Iranian Journal of Basic Medical Sciences
Atefeh HematiMahnaz Azarnia

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Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

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Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B cell Tolerance

B cell tolerance is maintained through mechanisms that can reversibly or irreversibly silence autoreactive B lymphocytes. Here is the latest research.

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