Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

April 16, 2021
Open Access

Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization.

Frontiers in Immunology
Gry PerssonJulie Di Cristofaro
April 13, 2021

Multimodal investigation of rat hepatitis E virus antigenicity: implications for infection, diagnostics, and vaccine efficacy.

Journal of Hepatology
Siddharth SridharKwok-Yung Yuen
April 7, 2021
Open Access

Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2.

BioRxiv : the Preprint Server for Biology
Emily C GaleEric A Appel
April 5, 2021

COVID-19 Vaccine for Elderly: Should We Be Reactive or Proactive?

Acta Medica Indonesiana
Siti Setiati, Jessica Marsigit
April 5, 2021
Open Access

Platelet antibodies identification: comparison between two laboratory tests.

Hematology, Transfusion and Cell Therapy
Valeria de Freitas DutraCarolina Bonet Bub
April 4, 2021

Characteristics of immune induction by transcutaneous vaccination using dissolving microneedle patches in mice.

International Journal of Pharmaceutics
Sachiko HirobeNaoki Okada
April 3, 2021
Open Access

Short or Long Interval between Priming and Boosting: Does It Impact on the Vaccine Immunogenicity?

Elena PettiniAnnalisa Ciabattini
April 3, 2021
Open Access

Silicone Oil-Based Nanoadjuvants as Candidates for a New Formulation of Intranasal Vaccines.

Agnieszka RazimAndrzej Myc
April 3, 2021
Open Access

Laser-assisted epicutaneous immunization to target human skin dendritic cells.

Experimental Dermatology
Christoph H TrippPatrizia Stoitzner
April 3, 2021
Open Access

Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery.

Drug Delivery and Translational Research
Ana Sara CordeiroMaría José Alonso

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Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B cell Tolerance

B cell tolerance is maintained through mechanisms that can reversibly or irreversibly silence autoreactive B lymphocytes. Here is the latest research.

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