Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

April 16, 2021

MHC heterogeneity and response of metastases to immunotherapy.

Cancer Metastasis Reviews
Ignacio AlgarraAngel M Garcia-Lora
April 16, 2021
Open Access

Toward the Next-Generation COVID-19 Vaccines That Circumvent Antigenic Drift while Defusing Viral Infection.

ACS Pharmacology & Translational Science
Ariel Fernández
April 16, 2021
Open Access

Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential.

Frontiers in Immunology
Ken MaesKarine Breckpot
April 16, 2021

Switchable CAR-T Cells Outperformed Traditional Antibody-Redirected Therapeutics Targeting Breast Cancers.

ACS Synthetic Biology
Yu J CaoStephanie A Kazane
April 13, 2021

Predictors of Response, Progression Free Survival, and Overall Survival in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Regan M MemmottTerence M Williams
April 12, 2021

TLRs in Mycobacterial Pathogenesis: Black and White or Shades of Gray.

Current Microbiology
Priyanka MehtaShibnath Mazumder
April 8, 2021
Open Access

CAR-T cell therapy: current limitations and potential strategies.

Blood Cancer Journal
Robert C Sterner, Rosalie M Sterner
April 8, 2021

The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Yuqian ZhangYang Li
April 9, 2021

Pancreatic Cancer Stem-Like Cells With High Calreticulin Expression Associated With Immune Surveillance.

Yasuhiro FujiwaraHiroaki Nagano
April 9, 2021
Open Access

Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma.

Journal for Immunotherapy of Cancer
Luan SunWei Gao
April 9, 2021
Open Access

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

The Journal of Clinical Investigation
Hanchen XuXiongbin Lu
April 7, 2021
Open Access

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429.

BioRxiv : the Preprint Server for Biology
Matthew McCallumDavid Veesler
April 7, 2021

Current Challenges and Strategies for Chimeric Antigen Receptor-T-Cell Therapy for Solid Tumors.

Critical Reviews in Immunology
Junfei Chen, Hua Jiang

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