Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

August 31, 2020
Open Access

Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth

Translational Oncology
Manisit DasLeaf Huang
September 1, 2020
Open Access

Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion

BioRxiv : the Preprint Server for Biology
C. J. FrangiehBenjamin Izar
August 30, 2020

Staphylococcal superantigen-like 12 induces the production of interleukin 4 in murine basophils

Biochemical and Biophysical Research Communications
Saishi NishiyamaShigeaki Hida
August 30, 2020
Open Access

T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion

International Journal of Molecular Sciences
Freya R Shepherd, James E McLaren
September 15, 2020
Open Access

Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3

Mathilde BoulpicanteSébastien Apcher
September 1, 2020

Development of programmed death receptor-1 and programmed death receptor-1 ligand in oral squamous cell carcinoma

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Zhi-Hong Chen, Ya-Dong Wu
August 21, 2020
Open Access

Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation

Cancer Immunology Research
Natália Rodrigues MantuanoHeinz Läubli
September 10, 2020

Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches

Annual Review of Medicine
Elizabeth A Thompson, Jonathan D Powell
August 23, 2020
Open Access

Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection

International Journal of Molecular Sciences
Ombretta MelaiuDoriana Fruci
August 26, 2020
Open Access

SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells

BioRxiv : the Preprint Server for Biology
Ana Dominguez AndresZe'ev A Ronai
September 17, 2020

Inhibition of BRAF Sensitizes Thyroid Carcinoma to Immunotherapy by Enhancing TsMHC-II-mediated Immune Recognition

The Journal of Clinical Endocrinology and Metabolism
Jingtai ZhiMing Gao
September 1, 2020

Nanoparticle Delivery of MnO2 and Anti-angiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma

ACS Applied Materials & Interfaces
Chih-Chun ChangYunching Chen
August 28, 2020
Open Access

BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy

Cell Reports
Debangshu SamantaGregg L Semenza
August 23, 2020
Open Access

Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma

Journal of Clinical Medicine
Maria-Filothei LazaridouBarbara Seliger
September 8, 2020
Open Access

Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy)

Journal of Translational Medicine
Paolo A AsciertoMagdalena Thurin

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