Feed Preview

Antisense Oligonucleotide - Therapies For ALS

Antisense Oligonucleotide - Therapies For ALS diagram by Vaccinationist, Wikimedia
Vaccinationist, Wikimedia

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Top 20 most recent papers
ACS Applied Materials & Interfaces

Aptamer-Functionalized DNA Origami for Targeted Co-delivery of Antisense Oligonucleotides and Doxorubicin to Enhance Therapy in Drug-Resistant Cancer Cells

ACS Applied Materials & InterfacesDecember 9, 2019
Qing-Shan PanXia Chu
Scientific Reports

SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1

Scientific ReportsDecember 10, 2019
Rebecca CacciottoloRuben J Cauchi
2
1
bioRxiv

Chromosomal length reference assembly for Diaphorina citri using single-molecule sequencing and Hi-C proximity ligation with manually curated genes in developmental, structural and immune pathways

bioRxivDecember 10, 2019
Prashant S HosmaniSurya Saha
15
Neurobiology of Disease

Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS

Neurobiology of DiseaseDecember 11, 2019
Ghanashyam D GhadgeRaymond P Roos
Nutrients

Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-B Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin)

NutrientsDecember 1, 2019
Constanze BuhrmannMehdi Shakibaei
The Science of the Total Environment

Responses of nitrogen transformation processes and N2 O emissions in biological nitrogen removal system to short-term ZnO nanoparticle stress

The Science of the Total EnvironmentDecember 4, 2019
Jinyu YeRan Yu
Neurobiology of Aging

Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease

Neurobiology of AgingNovember 1, 2019
Irene RosasManuel Menéndez-González
9
1
3
Biological Trace Element Research

Fluoride Compromises Testicular Redox Sensor, Gap Junction Protein, and Metabolic Status: Amelioration by Melatonin

Biological Trace Element ResearchDecember 11, 2019
Jitendra KumarRakesh Verma
3
International Journal of Molecular Sciences

Interruption of Jasmonic Acid Biosynthesis Causes Differential Responses in the Roots and Shoots of Maize Seedlings against Salt Stress

International Journal of Molecular SciencesDecember 9, 2019
Ramala Masood AhmadYuanxin Yan
Environmental Science and Pollution Research International

Encapsulation of cinnamon oil in whey protein counteracts the disturbances in biochemical parameters, gene expression, and histological picture of the liver and pancreas of diabetic rats

Environmental Science and Pollution Research InternationalDecember 13, 2019
Kamal A A MohammedMosaad A Abdel-Wahhab
Theriogenology

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes

TheriogenologyNovember 30, 2019
Wenjie JiangYong-Nan Xu
International Journal of Biological Macromolecules

Molecular cloning and functional characterization of a Cu/Zn superoxide dismutase from jellyfish Cyanea capillata

International Journal of Biological MacromoleculesDecember 10, 2019
Bo WangLi-ming Zhang
Bioanalysis

LC-MS quantification of oligonucleotides in biological matrices with SPE or hybridization extraction

BioanalysisNovember 1, 2019
Luc L A SipsLieve Dillen
Analytical and Bioanalytical Chemistry

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Analytical and Bioanalytical ChemistryDecember 9, 2019
Martin EnmarkTorgny Fornstedt
Carbohydrate Polymers

Ethylcellulose nanoparticles as a new "in vitro" transfection tool for antisense oligonucleotide delivery

Carbohydrate PolymersDecember 13, 2019
S LeitnerGabriela Calderó
Carbohydrate Polymers

Chemical characterization, antioxidant properties and anticancer activity of exopolysaccharides from Floccularia luteovirens

Carbohydrate PolymersDecember 13, 2019
Zhengjie LiuQi-He Chen
Atherosclerosis. Supplements

Lipoprotein(a) - Marker for cardiovascular risk and target for lipoprotein apheresis

Atherosclerosis. SupplementsDecember 1, 2019
Reinhard KlingelUlrich Julius
International Journal of Biological Macromolecules

Polysaccharide extracted from the leaves of Cyclocarya paliurus (Batal.) Iljinskaja enhanced stress resistance in Caenorhabditis elegans via skn-1 and hsf-1

International Journal of Biological MacromoleculesDecember 6, 2019
Chunxiu LinYun-Jiao Chen
Expert Review of Neurotherapeutics

An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies

Expert Review of NeurotherapeuticsDecember 12, 2019
Mahmoud Reza AshrafiAli Reza Tavasoli
5
Gene Therapy

The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model

Gene TherapyDecember 9, 2019
Weisong DuanChun-Yan Li
2
1

See more papers from this feed

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

© 2019 Meta ULC. All rights reserved
/feed-previews/antisense-oligonucleotide---therapies-for/506f6dc0-ba27-411f-bb11-c41821746796