Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

September 9, 2020

Identification of antisense lncRNAs targeting GSK3β as a regulator in major depressive disorder

Epigenomics
Zhifen LiuKerang Zhang
September 1, 2020

Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotides

Methods in Molecular Biology
Quynh Nguyen, Toshifumi Yokota
September 2, 2020
Review

The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential

Biochimica Et Biophysica Acta. Reviews on Cancer
Gouri PandyaManoj Garg
September 13, 2020

Synthesis of new riboflavin modified ODNs: Effect of riboflavin moiety on the G-quadruplex arrangement and stability

Bioorganic Chemistry
Valeria RomanucciGiovanni Di Fabio
September 1, 2020

Evaluating the Knockdown Activity of MALAT1 ENA Gapmers In Vitro

Methods in Molecular Biology
Shinzo IwashitaMakoto Koizumi
September 11, 2020

DNA triplex with conformationally locked sugar disintegrates to duplex: Insights from molecular simulations

Biochemical and Biophysical Research Communications
Pradeep Pant, Maria Fisher
September 5, 2020

DNA Analogues Modified at the Nonlinking Positions of Phosphorus

Accounts of Chemical Research
Pawan Kumar, Marvin H Caruthers
September 1, 2020

Development of Antisense Oligonucleotide Gapmers for the Treatment of Huntington's Disease

Methods in Molecular Biology
Tejal Aslesh, Toshifumi Yokota
September 11, 2020

Emerging Therapies in Friedreich's Ataxia

Expert Review of Neurotherapeutics
Theresa A ZesiewiczJoshua Vega
September 4, 2020
Open Access

C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy

Science Translational Medicine
Casey N CookLeonard Petrucelli
September 11, 2020
Open Access

Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction

Genome Biology
Norman HuangSheng Zhong
September 1, 2020

Targeted Gene Silencing in Malignant Hematolymphoid Cells Using GapmeR

Methods in Molecular Biology
Atish KizhakeyilNavin Kumar Verma
September 5, 2020
Review

Overview of Gene Therapy in Spinal Muscular Atrophy and Duchenne Muscular Dystrophy

Pediatric Pulmonology
Nicolas J Abreu, Megan A Waldrop
September 12, 2020

NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma

Cellular and Molecular Life Sciences : CMLS
Alina NaveedArcha H Fox
September 10, 2020
Review
Open Access

Targeting Alternative Splicing as a Potential Therapy for Episodic Ataxia Type 2

Biomedicines
Fanny JaudonLorenzo A Cingolani
September 4, 2020
Open Access

Phenotype Driven Analysis of Whole Genome Sequencing Identifies Deep Intronic Variants that Cause Retinal Dystrophies by Aberrant Exonization

Investigative Ophthalmology & Visual Science
Matteo Di ScipioAjoy Vincent
September 1, 2020

DNA-RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing

Methods in Molecular Biology
Rintaro Iwata HaraTakanori Yokota
September 1, 2020

Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion

Methods in Molecular Biology
Chaitra SathyaprakashYoshitsugu Aoki

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