Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

January 17, 2021
Open Access

Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration

Scientific Reports
Sathyanarayanan RanganayakiMuchukunte Mukunda Srinivas Bharath
January 17, 2021
Open Access

Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Communications Biology
Xiaoding HuBisrat G Debeb
January 16, 2021
Open Access

Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration

Pharmaceutics
Lorenzo Rivas-GarcíaCristina Sánchez-González
January 19, 2021

Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice

Journal of Lipid Research
Nicholas D LeBlondMorgan D Fullerton
January 14, 2021
Review
Open Access

Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer

Antioxidants
Shreyas Gaikwad, Sanjay K Srivastava
January 14, 2021
Review

AMPK: implications in osteoarthritis and therapeutic targets

American Journal of Translational Research
Junjie WangMingming Yan
January 16, 2021

JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy

Aging Cell
Zhiming LinLunhao Bai
January 18, 2021
Open Access

Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site

The Journal of Biological Chemistry
Liu LiuStephen W Ragsdale
January 14, 2021
Review

Mitochondrial Sirtuins and Doxorubicin-induced Cardiotoxicity

Cardiovascular Toxicology
Ling HeJuxiang Li
January 16, 2021
Open Access

Molecular mechanisms of astragaloside‑IV in cancer therapy (Review)

International Journal of Molecular Medicine
Tianqi ChenYingjie Jia

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