Feed Preview
Autophagy & Metabolism
Lin et al, PLOS OneAutophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.
Top 20 most recent papers
mTOR at the nexus of nutrition, growth, ageing and disease
Nature Reviews. Molecular Cell BiologyJanuary 16, 2020
Grace Y Liu, David M Sabatini
206
1
Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia
JCI InsightJanuary 17, 2020
Álvaro F FernándezBeth Levine
2
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression
NeuronJanuary 14, 2020
Bing BaiJunmin Peng
26
1
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
Nature CommunicationsJanuary 18, 2020
Liam D CassidyMasashi Narita
47
2
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells
AutophagyJanuary 17, 2020
Jun MatsudaYoshitaka Isaka
Dynamic post-translational modification profiling of M. tuberculosis -infected primary macrophages
ELifeJanuary 18, 2020
Jonathan M BudzikJeffery S Cox
3
Functional interaction between Fanconi anemia and mTOR pathways during stalled replication fork recovery
bioRxivJanuary 16, 2020
Matthew NolanIndrajit Chaudhury
7
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Mechanisms of Ageing and DevelopmentJanuary 19, 2020
Brian C GilmourEvandro F Fang
8
Survival mechanisms and xenobiotic susceptibility of keratinocytes exposed to metal-derived nanoparticles
Chemical Research in ToxicologyJanuary 14, 2020
Veronica Montesinos-CruzRodrigo Franco
A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress
International Journal of Molecular SciencesJanuary 17, 2020
Mohammad Amin OmidbakhshfardTsanko S Gechev
The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer
BiologyJanuary 18, 2020
David A Gewirtz
Coordination and Crosstalk between Autophagosome and Multivesicular Body Pathways in Plant Stress Responses
CellsJanuary 18, 2020
Mengxue WangZhixiang Chen
Zinc is essential for the transcription function of PGC-1α/Nrf2 signal pathway in human primary endometrial stromal cells
American Journal of Physiology. Cell PhysiologyJanuary 16, 2020
Xiaodan LuYanqiu Fang
Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer
TheranosticsJanuary 16, 2020
Ying WuWei Chen
1
Mitochondrial Ca2+ Uptake Relieves PalmitateInduced Cytosolic Ca2+ Overload in MIN6 Cells
Molecules and CellsJanuary 14, 2020
Luong Dai LyKyu-Sang Park
2
Curculigoside Protects against Excess-Iron-Induced Bone Loss by Attenuating Akt-FoxO1-Dependent Oxidative Damage to Mice and Osteoblastic MC3T3-E1 Cells
Oxidative Medicine and Cellular LongevityJanuary 18, 2020
Quanlong ZhangLuping Qin
Development of Inhalable Quinacrine Loaded Bovine Serum Albumin Modified Cationic Nanoparticles: Repurposing Quinacrine for Lung Cancer Therapeutics
International Journal of PharmaceuticsJanuary 15, 2020
Bhuvaneshwar VaidyaVivek Gupta
1
1
Structure and Function of the AAA+ ATPase p97, a Key Player in Protein Homeostasis
Sub-cellular BiochemistryJanuary 16, 2020
Petra HänzelmannHermann Schindelin
Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy
AgingJanuary 14, 2020
Donghao GuoYuan Zhong
Mucopolysaccharidosis-Plus Syndrome
International Journal of Molecular SciencesJanuary 16, 2020
Filipp VasilevTakanobu Otomo