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Autophagy & Metabolism

Autophagy & Metabolism diagram by Lin et al, PLOS One
Lin et al, PLOS One

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Top 20 most recent papers
Nature Reviews. Molecular Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Nature Reviews. Molecular Cell BiologyJanuary 16, 2020
Grace Y Liu, David M Sabatini
206
1
JCI Insight

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

JCI InsightJanuary 17, 2020
Álvaro F FernándezBeth Levine
2
Neuron

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression

NeuronJanuary 14, 2020
Bing BaiJunmin Peng
26
1
Nature Communications

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Nature CommunicationsJanuary 18, 2020
Liam D CassidyMasashi Narita
47
2
Autophagy

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

AutophagyJanuary 17, 2020
Jun MatsudaYoshitaka Isaka
ELife

Dynamic post-translational modification profiling of M. tuberculosis -infected primary macrophages

ELifeJanuary 18, 2020
Jonathan M BudzikJeffery S Cox
3
bioRxiv

Functional interaction between Fanconi anemia and mTOR pathways during stalled replication fork recovery

bioRxivJanuary 16, 2020
Matthew NolanIndrajit Chaudhury
7
Mechanisms of Ageing and Development

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

Mechanisms of Ageing and DevelopmentJanuary 19, 2020
Brian C GilmourEvandro F Fang
8
Chemical Research in Toxicology

Survival mechanisms and xenobiotic susceptibility of keratinocytes exposed to metal-derived nanoparticles

Chemical Research in ToxicologyJanuary 14, 2020
Veronica Montesinos-CruzRodrigo Franco
International Journal of Molecular Sciences

A Biostimulant Obtained from the Seaweed Ascophyllum nodosum Protects Arabidopsis thaliana from Severe Oxidative Stress

International Journal of Molecular SciencesJanuary 17, 2020
Mohammad Amin OmidbakhshfardTsanko S Gechev
Biology

The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer

BiologyJanuary 18, 2020
David A Gewirtz
Cells

Coordination and Crosstalk between Autophagosome and Multivesicular Body Pathways in Plant Stress Responses

CellsJanuary 18, 2020
Mengxue WangZhixiang Chen
American Journal of Physiology. Cell Physiology

Zinc is essential for the transcription function of PGC-1α/Nrf2 signal pathway in human primary endometrial stromal cells

American Journal of Physiology. Cell PhysiologyJanuary 16, 2020
Xiaodan LuYanqiu Fang
Theranostics

Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer

TheranosticsJanuary 16, 2020
Ying WuWei Chen
1
Molecules and Cells

Mitochondrial Ca2+ Uptake Relieves PalmitateInduced Cytosolic Ca2+ Overload in MIN6 Cells

Molecules and CellsJanuary 14, 2020
Luong Dai LyKyu-Sang Park
2
Oxidative Medicine and Cellular Longevity

Curculigoside Protects against Excess-Iron-Induced Bone Loss by Attenuating Akt-FoxO1-Dependent Oxidative Damage to Mice and Osteoblastic MC3T3-E1 Cells

Oxidative Medicine and Cellular LongevityJanuary 18, 2020
Quanlong ZhangLuping Qin
International Journal of Pharmaceutics

Development of Inhalable Quinacrine Loaded Bovine Serum Albumin Modified Cationic Nanoparticles: Repurposing Quinacrine for Lung Cancer Therapeutics

International Journal of PharmaceuticsJanuary 15, 2020
Bhuvaneshwar VaidyaVivek Gupta
1
1
Sub-cellular Biochemistry

Structure and Function of the AAA+ ATPase p97, a Key Player in Protein Homeostasis

Sub-cellular BiochemistryJanuary 16, 2020
Petra HänzelmannHermann Schindelin
Aging

Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy

AgingJanuary 14, 2020
Donghao GuoYuan Zhong
International Journal of Molecular Sciences

Mucopolysaccharidosis-Plus Syndrome

International Journal of Molecular SciencesJanuary 16, 2020
Filipp VasilevTakanobu Otomo

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