BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

October 25, 2020
Open Access

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

BioRxiv : the Preprint Server for Biology
A. KhatebZe'ev A Ronai
October 24, 2020

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia

Godelieve MeunierDidier Bouscary
October 21, 2020

Assessment of co-composting of sewage sludge, woodchips, and sawdust: feedstock quality and design and compilation of computational model

Environmental Science and Pollution Research International
Somayeh GolbazMahdi Farzadkia
October 21, 2020
Open Access

Development of Conformational Antibodies to Detect Bcl-xL's Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells

International Journal of Molecular Sciences
Alexis GonneaudChristel Marquette
October 21, 2020
Open Access

Investigation of INDEL variants in apoptosis: the relevance to gastric cancer

BMC Medical Genetics
Giovanna Chaves CavalcanteÂndrea Ribeiro-Dos-Santos
October 17, 2020
Open Access

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor

ACS Medicinal Chemistry Letters
Le WangAndrew James Souers
October 18, 2020
Open Access

Atorvastatin Augments Gemcitabine-Mediated Anti-Cancer Effects by Inhibiting Yes-Associated Protein in Human Cholangiocarcinoma Cells

International Journal of Molecular Sciences
Koh KitagawaHitoshi Yoshiji
October 18, 2020
Open Access

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

International Journal of Molecular Sciences
Emma C JosefssonChloe James
October 20, 2020
Open Access

Clinical Features of 50 Patients With Primary Adrenal Lymphoma

Frontiers in Endocrinology
Yan WangTao Chen
October 27, 2020

Overexpression of FADD and Bcl-XS proteins as novel prognostic biomarkers for surgically resected non-small cell lung cancer

Cancer Biomarkers : Section a of Disease Markers
Lingjiao ChenSongqing Fan
October 21, 2020
Open Access

Combination of arsenic trioxide epigallocatechin-3-gallate and Resveratrol synergistically suppresses the growth and invasion in Brain tumor cell lines

BioRxiv : the Preprint Server for Biology
R. S. SajjadiMojtaba Saffari
October 20, 2020

Prognostic significance of Bcl-2 expression in primary cutaneous B-cell lymphoma: a reappraisal

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia
Alessandro PileriNicola Pimpinelli
October 28, 2020

BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2

Cell Proliferation
Zhenshuo ZhuJinlian Hua
October 21, 2020
Open Access

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

BioRxiv : the Preprint Server for Biology
R. MiyamotoAkihiko Yokoyama
October 18, 2020

Tumor Targeted Nanoparticles Improve Therapeutic Index of BCL2 and MCL1 dual inhibition

Neeta Bala TannanAnas Younes

Sign up to follow this feed and discover related papers.

Related Feeds

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.


An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Axis Formation

Three major axes, anteroposterior, dorsoventral, and left-right axes, patterned during embryogenesis determine the overall body plan of an organism. Discover the latest research on axis formation here.

© 2020 Meta ULC. All rights reserved