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Blood Brain Barrier Chips

Blood Brain Barrier Chips diagram by Tian et al, PLOS One
Tian et al, PLOS One

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Top 20 most recent papers
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchJanuary 24, 2020
Priya KumthekarNuhad K Ibrahim
Frontiers in Pharmacology

Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Frontiers in PharmacologyJanuary 24, 2020
Stéphanie HostenbachJacques De Keyser
ACS Chemical Neuroscience

Test-retest repeatability of [18 F]MC225-PET in rodents: A tracer for imaging of P-gp function

ACS Chemical NeuroscienceJanuary 22, 2020
Lara García-VarelaGert Luurtsema
Infection and Immunity

Neisseria meningitidis induces pathology-associated cellular and molecular changes in trigeminal Schwann cells

Infection and ImmunityJanuary 23, 2020
Ali DelbazJenny A K Ekberg
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

Sites and sources of sympathoexcitation in obese male rats: role of brain insulin

American Journal of Physiology. Regulatory, Integrative and Comparative PhysiologyJanuary 23, 2020
Zhigang ShiVirginia L Brooks
International Journal of Pharmaceutics

ChABC-Loaded PLGA Nanoparticles: A Comprehensive Study on Biocompatibility, Functional Recovery, and Axonal Regeneration in Animal Model of Spinal Cord Injury

International Journal of PharmaceuticsJanuary 19, 2020
Monireh AziziHamid Omidian
Journal of Ethnopharmacology

A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of aconitum alkaloids

Journal of EthnopharmacologyJanuary 23, 2020
Jiaojiao CongChunyong Wu
Current Pharmaceutical Design

A Current Nanoparticles approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

Current Pharmaceutical DesignJanuary 18, 2020
Mohammad Azam AnsariNiyaz Ahmad
Journal of Neurochemistry

microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury

Journal of NeurochemistryJanuary 18, 2020
Wu JingchuanXiaochuan Sun

Nano-Therapies for Glioblastoma Treatment

CancersJanuary 23, 2020
Edouard Alphandéry
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Effect of butylphthalide on blood-brain barrier after cerebral hemorrhage in SD rats and the mechanisms

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesJanuary 24, 2020
Ke QiuWei Lu
Experimental Neurology

Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury

Experimental NeurologyJanuary 20, 2020
Pinar Eser OcakJohn H Zhang

Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke

PharmaceuticsJanuary 18, 2020
Santos BlancoMaría Adolfina Ruiz
Current Pharmaceutical Design

Recent advances on anti-tumor agents-loaded polymeric and lipid based nano-carriers for the treatment of brain cancer

Current Pharmaceutical DesignJanuary 18, 2020
Amanda CanoMaria Luisa García

The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

BiomoleculesJanuary 23, 2020
Terezia KiskovaMonika Kassayova
Expert Review of Neurotherapeutics

Alzheimer's disease: review of current nanotechnological therapeutic strategies

Expert Review of NeurotherapeuticsJanuary 21, 2020
Ewa Baranowska-Wójcik, Dominik Szwajgier

Experimental rat model of chronic cerebral hypoperfusion-reperfusion mimicking normal perfusion pressure breakthrough phenomenon

NeurocirugíaJanuary 18, 2020
Juan Manuel RevueltaRaquel Gutiérrez-González
Archives of Biochemistry and Biophysics

Phoenixin-14 protects human brain vascular endothelial cells against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced inflammation and permeability

Archives of Biochemistry and BiophysicsJanuary 22, 2020
Benping Zhang, Jiebing Li
Neural Regeneration Research

Fast-tracking regenerative medicine for traumatic brain injury

Neural Regeneration ResearchJanuary 22, 2020
Brooke BonsackCesar V Borlongan
The Neuroradiology Journal

Radiological predictors of hemorrhagic transformation after acute ischemic stroke: An evidence-based analysis

The Neuroradiology JournalJanuary 24, 2020
Nada ElsaidAhmed Saied

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