The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.
Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.
Membrane trafficking is the process through which macromolecules and other cargo are distributed throughout cell, released from the cell, or taken into the cell from extracellular space. Here is the latest research on mechanisms that regulate membrane trafficking.
The electron transport chain (ETC) facilitates the transfer of electrons through redox while transferring protons across the membrane into the intermembrane space. This feed focuses on the structure and mechanism of the ETC as well as mitochondrial disorders caused by defects in the oxidative phosphorylation pathway.
Multiprotein adhesion structures allow the interaction of a cell with the extracellular matrix comprised of extracellular molecules that ensure tissue integrity and play a role in cell growth, migration, and differentiation. Here is the latest research.
The extracellular matrix (ECM) ensures tissue integrity and play a role in cell growth, migration, and differentiation. ECM turnover, therefore, is essential for tissue maintenance. Here is the latest research on mechanisms that regulate ECM turnover.
The extracellular matrix (ECM) ensures tissue integrity and play a role in cell growth, migration, and differentiation. ECM abnormalities play a key role in tumorigenesis and metastasis. Here is the latest research on ECM in cancer.
G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, participate in the regulation of many physiological functions and are the targets of approximately 30% of currently marketed drugs. Here is the latest research.