Brain Organoids in Disease Modeling

Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.

December 30, 2020

Human Brain Surrogates Research: The Onrushing Ethical Dilemma

The American Journal of Bioethics : AJOB
Henry T Greely
January 13, 2021

Neuroinvasion of SARS-CoV-2 in human and mouse brain

The Journal of Experimental Medicine
Eric SongAkiko Iwasaki
January 13, 2021
Open Access

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Nature Communications
Samaneh K SarvestaniEmina H Huang
January 1, 2021
Review
Open Access

Cilia, ciliopathies and hedgehog-related forebrain developmental disorders

Neurobiology of Disease
Abraham Andreu-CerveraSylvie Schneider-Maunoury
December 29, 2020
Open Access

A screen of brain organoids to study neurodevelopmental disease

Nature
Adriana Cherskov, Nenad Sestan
December 19, 2020

The impact of oxygen availability and multilineage communication on organoid maturation

Antioxidants & Redox Signaling
Philipp Wörsdörfer, Süleyman Ergün
January 16, 2021

Advances in CNS organoids: a focus on organoid-based models for motor neuron disease

Tissue Engineering. Part C, Methods
Renata Vieira de SaJeroen Pasterkamp
December 31, 2020
Review
Open Access

Vascularized Organoids: A More Complete Model

International Journal of Stem Cells
Jin Yu
January 6, 2021
Review
Open Access

Monoclonal Antibody-Based Immunotherapy and Its Role in the Development of Cardiac Toxicity

Cancers
Mohit KumarSakthivel Sadayappan
December 29, 2020
Review
Open Access

Retinal organoids: a window into human retinal development

Development
Michelle O'Hara-Wright, Anai Gonzalez-Cordero
December 21, 2020
Review

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies

Trends in Molecular Medicine
Moran Dvela-LevittAnna Greka
January 2, 2021
Open Access

Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids

Viruses
Aleksandra PettkeMarjo-Riitta Puumalainen
January 5, 2021
Review
Open Access

Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments

International Journal of Medical Sciences
Xue ZhangZhongtao Gai
December 29, 2020
Open Access

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Frontiers in Cell and Developmental Biology
Ana Rita GomesMaria Margarida Diogo
January 12, 2021
Review
Open Access

Review: In vitro Cell Platform for Understanding Developmental Toxicity

Frontiers in Genetics
Junkai XieChongli Yuan
January 5, 2021
Open Access

Generation of Multiple Ocular Lineages from Human Pluripotent Stem Cells and Its Application to Regenerative Medicine

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Ryuhei Hayashi

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