Brain Organoids in Disease Modeling

Brain organoids are three-dimensional cell culture models derived from human pluripotent stem cells. Since they resemble the embryonic brain, they can be used to help study brain biology, early brain development, and brain diseases. Discover the latest research on brain organoids in disease modeling here.

December 30, 2020

Human Brain Surrogates Research: The Onrushing Ethical Dilemma

The American Journal of Bioethics : AJOB
Henry T Greely
January 13, 2021

Neuroinvasion of SARS-CoV-2 in human and mouse brain

The Journal of Experimental Medicine
Eric SongAkiko Iwasaki
January 13, 2021
Open Access

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Nature Communications
Samaneh K SarvestaniEmina H Huang
January 1, 2021
Open Access

Cilia, ciliopathies and hedgehog-related forebrain developmental disorders

Neurobiology of Disease
Abraham Andreu-CerveraSylvie Schneider-Maunoury
December 29, 2020
Open Access

A screen of brain organoids to study neurodevelopmental disease

Adriana Cherskov, Nenad Sestan
December 19, 2020

The impact of oxygen availability and multilineage communication on organoid maturation

Antioxidants & Redox Signaling
Philipp Wörsdörfer, Süleyman Ergün
January 16, 2021

Advances in CNS organoids: a focus on organoid-based models for motor neuron disease

Tissue Engineering. Part C, Methods
Renata Vieira de SaJeroen Pasterkamp
December 31, 2020
Open Access

Vascularized Organoids: A More Complete Model

International Journal of Stem Cells
Jin Yu
January 6, 2021
Open Access

Monoclonal Antibody-Based Immunotherapy and Its Role in the Development of Cardiac Toxicity

Mohit KumarSakthivel Sadayappan
December 29, 2020
Open Access

Retinal organoids: a window into human retinal development

Michelle O'Hara-Wright, Anai Gonzalez-Cordero
December 21, 2020

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies

Trends in Molecular Medicine
Moran Dvela-LevittAnna Greka
January 2, 2021
Open Access

Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids

Aleksandra PettkeMarjo-Riitta Puumalainen
January 5, 2021
Open Access

Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments

International Journal of Medical Sciences
Xue ZhangZhongtao Gai
December 29, 2020
Open Access

Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids

Frontiers in Cell and Developmental Biology
Ana Rita GomesMaria Margarida Diogo
January 12, 2021
Open Access

Review: In vitro Cell Platform for Understanding Developmental Toxicity

Frontiers in Genetics
Junkai XieChongli Yuan
January 5, 2021
Open Access

Generation of Multiple Ocular Lineages from Human Pluripotent Stem Cells and Its Application to Regenerative Medicine

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Ryuhei Hayashi

Sign up to follow this feed and discover related papers.

Related Feeds

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Artificial Cell Models

This feed focuses on biomimetrics, synthetic biology and bio- and tissue-engineering approaches used for modeling human diseases.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

© 2021 Meta ULC. All rights reserved