Feed Preview

Cell Atlas of the human Thymus: Development & Aging

Cell Atlas of the human Thymus: Development & Aging diagram by #N/A

Examining the genomics, transcriptomics, proteomics, and metabolomics of the human thymus gland at the single cell level will help build a single cell atlas of this gland, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the thymus gland during development and aging. Discover the latest research on the cell atlas of the human thymus here.

Top 20 most recent papers

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

ScienceAugust 29, 2019
Francois P LegouxOlivier Lantz
Nature Immunology

Molecular mechanisms of lineage decisions in metabolite-specific T cells

Nature ImmunologyAugust 22, 2019
Francois P LegouxOlivier Lantz

The hematopoietic landscape at single-cell resolution reveals unexpected stem cell features in naked mole-rats

bioRxivNovember 29, 2019
Stephan EmmrichVera Gorbunova
Scientific Reports

Genetic lines respond uniquely within the chicken thymic transcriptome to acute heat stress and low dose lipopolysaccharide

Scientific ReportsSeptember 20, 2019
Melissa S MonsonSusan J. Lamont
Cell Research

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

Cell ResearchNovember 15, 2019
Rongqun GuoJinyong Wang
Frontiers in Immunology

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Frontiers in ImmunologyOctober 11, 2019
Susanne HerppichJochen Huehn
Cell Reports

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Cell ReportsNovember 26, 2019
Izumi OhigashiYousuke Takahama

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos

ImmunityOctober 13, 2019
Yang ZengHong-bo Hu

High-Fat Diet from Weaning until Early Adulthood Impairs T Cell Development in the Thymus

LipidsOctober 13, 2019
Hao LiKunpeng Wu
Open Forum Infectious Diseases

Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV

Open Forum Infectious DiseasesOctober 1, 2019
Giovanni GuaraldiCristina Mussini
Cell Reports

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

Cell ReportsJune 18, 2019
Likai TanSarina Ravens
Aging Cell

Reversal of epigenetic aging and immunosenescent trends in humans

Aging CellSeptember 10, 2019
Gregory M FahySteve Horvath
The Journal of Experimental Medicine

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

The Journal of Experimental MedicineAugust 23, 2019
Saskia HemmersAlexander Yu Rudensky

Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice

ImmunobiologyNovember 19, 2019
Li Na GuoYu-Rong Chai
Experimental and Therapeutic Medicine

Identification of potential agents for thymoma by integrated analyses of differentially expressed tumour-associated genes and molecular docking experiments

Experimental and Therapeutic MedicineAugust 28, 2019
Xiao-Dong WangRuo-Chuan Liu
Scientific Data

High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire

Scientific DataJuly 4, 2019
Biagio Di LorenzoBruno Silva-Santos
European Journal of Immunology

Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice

European Journal of ImmunologyNovember 11, 2019
Yun PanXiao-Ping Zhong
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc

Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, IncOctober 22, 2019
Marina ViveroLynette Marie Sholl
Mucosal Immunology

Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1- T-bet+ intraepithelial lymphocyte precursors

Mucosal ImmunologyNovember 11, 2019
Jonas F HummelYakup Tanriver
Frontiers in Immunology

Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development

Frontiers in ImmunologyAugust 13, 2019
Theodore V PetersonJoseph M Reynolds

See more papers from this feed

Related Feeds

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Adult Kidney Organoids at Single Cell Resolution

Single-cell RNA sequencing of the adult human kidney transcriptome can provide molecular information about cell-specific responses to environmental variables and disease states. This information can provide a dataset to benchmark human kidney organoids. Discover the latest research on adult kidney organoids at single cell resolution here.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging Genetics

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.


An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

© 2019 Meta ULC. All rights reserved