Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

January 21, 2022
Preprint
Open Access

Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy

BioRxiv : the Preprint Server for Biology
E. DhueyAndy J. Minn
January 21, 2022
Preprint
Open Access

Immunotherapy of glioblastoma explants induces interferon-γ responses and immune cell rearrangements in tumor center, but not periphery

BioRxiv : the Preprint Server for Biology
T. ShekarianGregor Hutter
January 21, 2022

Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Adam C PalmerPeter K Sorger
January 21, 2022

First-in-human dose escalation study of cyclin-dependent kinase-9 inhibitor VIP152 in patients with advanced malignancies shows early signs of clinical efficacy.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jennifer R DiamondVictor Moreno
January 21, 2022

[Chemotherapy for Older Patients with Cancer].

Gan to kagaku ryoho. Cancer & chemotherapy
Ayako Mitsuma, Yuichi Ando
January 21, 2022

Identification of m6A-Associated Gene DST as a Prognostic and Immune-Associated Biomarker in Breast Cancer Patients.

International Journal of General Medicine
Xiangyuan QiuJinwu Peng
January 21, 2022
Case Report
Open Access

Durvalumab-Induced Demyelinating Lesions in a Patient With Extensive-Stage Small-Cell Lung Cancer: A Case Report.

Frontiers in Pharmacology
Wenhui LiuFang Ma
January 21, 2022
Open Access

Immune Checkpoint Inhibitor-Induced Cerebral Pseudoprogression: Patterns and Categorization.

Frontiers in Immunology
Hans UrbanMartin Voss
January 21, 2022
Open Access

Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer.

Frontiers in Immunology
Sandra van WilpeNiven Mehra
January 21, 2022
Open Access

A Prognostic Model for Breast Cancer Based on Cancer Incidence-Related DNA Methylation Pattern.

Frontiers in Genetics
Zhenchong XiongZeyu Shuang

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