Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.
Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.
Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.
Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur. Discover the latest research on cell cycle modeling here.
Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.
Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms. Discover the latest research on centromere in DNA replication here.
The centromere is a specialized DNA sequence of a chromosome that links a pair of sister chromatids. During prophase, specialized regions of the centromeres known as kinetochores attach chromosomes to spindle fibers. Here is the latest research on centromeres and the kinetochore.
Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. Here is the latest research on this chemical proteomic method for pharmacological discovery research.
Collective cell migration is the coordinated movement of cells, which organize tissues during morphogenesis, repair and some cancers. Here is the latest research.
Cyclins and cylin-dependent kinases (CDKs) are two classes of regulatory molecules that determine a cell’s progression through cell cycle. Here is the latest research.
Investigating human cellular proteins through a combination of highly multiplexed imaging and proteomic analyses can help characterize all human cells at the proteomic level. Discover the latest research on deep visual proteomics here.