Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

October 17, 2021
Review

"NOVEL MECHANISMS TARGETED BY DRUG TRIALS IN PULMONARY ARTERIAL HYPERTENSION".

Chest
David F CondonDavid F Condon
October 15, 2021

Clinical and genetic characterization of adult-onset leukoencephalopathy caused by CSF1R mutations.

Annals of Clinical and Translational Neurology
Pei-Chien TsaiYi-Chu Liao
October 15, 2021
Review

Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR).

Chemical Biology & Drug Design
Mar'iyah Najihah AbdullahShafida Abd Hamid
October 15, 2021
Open Access

Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers.

Frontiers in Oncology
Zhonghua TaoXichun Hu
October 15, 2021

Bockenheimer Disease is Associated With a TEK Variant.

Cold Spring Harbor Molecular Case Studies
Christopher L SudduthArin K Greene
October 15, 2021
Review

FMS-Like Tyrosine Kinase 3 Inhibitors for the Treatment of Acute Myeloid Leukemia.

Clinical Lymphoma, Myeloma & Leukemia
Elli D NovatchevaAaron M Goodman
October 15, 2021

Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Ku-Geng HuoMing-Sound Tsao
October 14, 2021
Preprint
Open Access

Soluble angiotensin-converting enzyme 2 as a prognostic biomarker for disease progression in patients infected with SARS-CoV-2

MedRxiv : the Preprint Server for Health Sciences
N. Diaz TroyanoFrancisco Rodriguez Frias
October 13, 2021
Open Access

Biallelic Variants in EPHA2 Identified in Three Large Inbred Families with Early-Onset Cataract.

International Journal of Molecular Sciences
Priya JarwarZubair M Ahmed
October 13, 2021
Open Access

The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism.

International Journal of Molecular Sciences
Yan XuDimitar B Nikolov
October 13, 2021
Open Access

Aberrant Signaling Pathways in Sinonasal Intestinal-Type Adenocarcinoma.

Cancers
Cristina RiobelloMario A Hermsen
October 13, 2021
Review
Open Access

AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew.

Cancers
Almira AuyezEugene Tulchinsky

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