Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

April 18, 2020

Regulatory mechanism for the transmembrane receptor that mediates bidirectional vitamin A transport

Proceedings of the National Academy of Sciences of the United States of America
Ming ZhongHui Sun
April 17, 2020

Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology

Journal of Medicinal Chemistry
Marialuisa MocciaFrancesca Carlomagno
April 8, 2020
Case Report
Open Access

Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML

Case Reports in Oncological Medicine
Kousuke WatanabeTakahide Nagase
May 15, 2020

Sgc8-c Aptamer as a Potential Theranostic Agent for Hemato-Oncological Malignancies

Cancer Biotherapy & Radiopharmaceuticals
Estefanía SiccoVictoria Calzada
April 27, 2020

Construction of Light-Activated Neurotrophin Receptors Using the Improved Light-Induced Dimerizer (iLID)

Journal of Molecular Biology
Jen M HopeBianxiao Cui
May 8, 2020
Open Access

The Role of Rho GTPases in VEGF Signaling in Cancer Cells

Analytical Cellular Pathology (Amsterdam)
Nada El BabaMirvat El-Sibai
April 3, 2020

The role of CXC cytokines as biomarkers and potential targets in hepatocellular carcinoma

Mathematical Biosciences and Engineering : MBE
Yong Hui WangJie Yang
May 19, 2020

Optical Activation of TrkB Signaling

Journal of Molecular Biology
Peiyuan HuangLiting Duan
April 17, 2020

Insulin and EGF receptor family members share parallel activation mechanisms

Protein Science : a Publication of the Protein Society
Kathryn M FergusonMark A Lemmon
May 28, 2020
Open Access

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

Frontiers in Cell and Developmental Biology
Mei-Yu QuanJin-San Zhang
May 13, 2020
Open Access

ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia

Journal of Experimental & Clinical Cancer Research : CR
Doh Yu HwangYoo Hong Min

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