Feed Preview

Chagas Disease

Chagas Disease diagram by undefined

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

Top 20 most recent papers
Scientific Reports

Alteration of the aggregation and spatial organization of the vector of Chagas disease, Triatoma infestans, by the parasite Trypanosoma cruzi

Scientific ReportsNovember 22, 2019
Stéphanie DepickèreJean-Louis Deneubourg
1
bioRxiv

Is vectorial transmission of Trypanosoma cruzi an efficient route to support high infection rates in sylvatic hosts?”

bioRxivNovember 29, 2019
Mauricio Santos-VegaFelipe Guhl
7
Scientific Reports

Analysis of mRNA processing at whole transcriptome level, transcriptomic profile and genome sequence refinement of Trypanosoma cruzi

Scientific ReportsNovember 22, 2019
Francisco Callejas-HernándezManuel F Fresno
3
Scientific Reports

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Scientific ReportsNovember 26, 2019
Dunia Margarita Medina-BuelvasLibia Vega
bioRxiv

Phylobioactive hotspots identified through multidimensional profiling of botanical drugs used to treat Chagas disease in Bolivia and Dioscorides' De Materia Medica

bioRxivDecember 2, 2019
Andrea SalmJürg Gertsch
1
Angewandte Chemie

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-trypanosomal Macrolides

Angewandte ChemieNovember 19, 2019
Matthew J AnketellIan Paterson
10
The Journal of Antimicrobial Chemotherapy

Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease

The Journal of Antimicrobial ChemotherapyNovember 21, 2019
Yves L JacksonFrançois Chappuis
2
Acta Tropica

Interventions to Bring Comprehensive Care to People with Chagas Disease: Experiences in Bolivia, Argentina and Colombia

Acta TropicaDecember 4, 2019
María Jesús PinazoMauricio Javier Vera
Transfusion

Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease

TransfusionDecember 5, 2019
Paula Fraiman BlatytaNational Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study III (REDS-III) International Component, Brazil
1
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: A prospective cohort study in two Spanish referral centres

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious DiseasesNovember 15, 2019
Clara Crespillo-AndujarJosé Antonio Pérez-Molina
European Journal of Medicinal Chemistry

Hit-to-lead optimization of novel 2-alkylaminomethylquinoline derivatives as anti-chagas agents

European Journal of Medicinal ChemistryNovember 13, 2019
Gisela C MusciaFernanda María Frank
PLoS Neglected Tropical Diseases

Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

PLoS Neglected Tropical DiseasesNovember 21, 2019
Mariana StraussJavier Martín
2
BMC Public Health

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries

BMC Public HealthDecember 5, 2019
Labanté Outcha DaréPierre-Marie Preux
3
Parasites & Vectors

Disentangling Trypanosoma cruzi transmission cycle dynamics through the identification of blood meal sources of natural populations of Triatoma dimidiata in Yucatán, Mexico

Parasites & VectorsNovember 29, 2019
Joel Israel Moo-MillanEtienne Waleckx
BioMed Research International

Sarcocystis spp. in Romanian Slaughtered Cattle: Molecular Characterization and Epidemiological Significance of the Findings

BioMed Research InternationalOctober 13, 2019
Kálmán ImreAdriana Morar
Journal of Chemical Information and Modeling

Discovery of Potent, Reversible and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach

Journal of Chemical Information and ModelingNovember 25, 2019
Mariana C SouzaAdriano Defini Andricopulo
1
European Journal of Medicinal Chemistry

Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities

European Journal of Medicinal ChemistryNovember 16, 2019
Francisco do Vale Chaves E MelloIsrael Felzenszwalb
Parasites & Vectors

Development and evaluation of a duplex TaqMan qPCR assay for detection and quantification of Trypanosoma cruzi infection in domestic and sylvatic reservoir hosts

Parasites & VectorsNovember 29, 2019
Diana Patricia WehrendtAlejandro Gabriel Schijman
5
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases

Economic costs of Chagas disease in Colombia in 2017: a social perspective

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious DiseasesNovember 23, 2019
Mario J Olivera, Giancarlo Buitrago
7
ACS Omega

Combining Charge Density Analysis with Machine Learning Tools To Investigate the Cruzain Inhibition Mechanism

ACS OmegaNovember 26, 2019
Adriano M LuchiNélida Maria Peruchena

See more papers from this feed

Related Feeds

AIDS Malignancies

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Ascariasis

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

© 2019 Meta ULC. All rights reserved
/feed-previews/chagas-disease/c6a9d49b-61c3-42de-81f5-f231bf9bc679