Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

October 16, 2021
Open Access

Unusual features and localization of the membrane kinome of Trypanosoma brucei.

PloS One
Bryan C JensenMarilyn Parsons
October 15, 2021
Open Access

Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes.

Scientific Reports
Israel MolinaMaria Carmo P Nunes
October 14, 2021

Cardiac Fibrosis and Changes in Left Ventricle Function in Patients with Chronic Chagas Heart Disease.

Arquivos brasileiros de cardiologia
João Bosco de Figueiredo SantosRoberto Magalhães Saraiva
October 13, 2021
Preprint
Open Access

Highly similar sequence and structure yet different biophysical behaviour: A computational study of two triosephosphate isomerases

BioRxiv : the Preprint Server for Biology
C. Chavez-Garcia, Mikko Karttunen
October 13, 2021

Eco-epidemiology of vectorial Trypanosoma cruzi transmission in a region of northeast Brazil.

Acta Tropica
Flavia Dos SantosCarlos Roberto Franke
October 12, 2021

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay.

PLoS Neglected Tropical Diseases
Nina SvensenManu De Rycker
October 11, 2021

Ent-kaurane diterpenes isolated from n-hexane extract of Baccharis sphenophylla by bioactivity-guided fractionation target the acidocalcisomes in Trypanosoma cruzi.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Thais A da Costa-SilvaJoão Henrique G Lago
October 11, 2021

Dual chamber pacemaker implantation in woman with twin pregnancy and Chagas cardiomyopathy guided by 2D transthoracic echocardiography.

Indian Pacing and Electrophysiology Journal
Paul M PrezaVictoria C Armas
October 9, 2021
Open Access

The potential risk of enzootic Trypanosoma cruzi transmission inside four training and re-training military battalions (BITER) in Colombia.

Parasites & Vectors
Omar Cantillo-BarrazaClaudia Méndez
October 8, 2021

Molecular evidence of Leishmania spp. in spider monkeys (Ateles geoffroyi) from The Tuxtlas Biosphere Reserve, Veracruz, Mexico.

Veterinary Research Communications
Carlos D Pérez-BrígidoAnabel E Rodríguez
October 8, 2021

Recommendations for Screening and Diagnosis of Chagas Disease in the United States.

The Journal of Infectious Diseases
Colin J ForsythU.S. Chagas Diagnostic Working Group
October 7, 2021

The prognostic value of the Incremental Shuttle Walk Test in Chagas cardiomyopathy.

Disability and Rehabilitation
Matheus Ribeiro ÁvilaHenrique Silveira Costa
October 5, 2021

Biological Parameters of Two Triatoma protracta Subspecies (Hemiptera: Reduviidae).

Journal of Medical Entomology
B Nogueda-TorresJ G Michel-Parra
October 5, 2021

Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas' disease.

Antimicrobial Agents and Chemotherapy
Marta LimaSusan Wyllie
October 5, 2021

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease.

PLoS Neglected Tropical Diseases
Danya A DeanLaura-Isobel McCall

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