Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

July 1, 2020
Open Access

Asymptomatic Strongyloidiasis among Latin American Migrants in Spain: A Community-Based Approach

Pathogens
Violeta Ramos-Sesma Corazones Sin Chagas Platform
June 23, 2020

Effect of Posaconazole in an in vitro model of cardiac fibrosis induced by Trypanosoma cruzi

Molecular and Biochemical Parasitology
Lindice M NisimuraLuciana R Garzoni
July 1, 2020
Open Access

Autochthonous Chagas Disease in the United States: How Are People Getting Infected?

The American Journal of Tropical Medicine and Hygiene
Norman L Beatty, Stephen A Klotz
July 1, 2020

Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi

Antimicrobial Agents and Chemotherapy
Julianna Siciliano de AraújoMaria de Nazaré Correia Soeiro
June 28, 2020

Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion

The Journal of Immunology : Official Journal of the American Association of Immunologists
Angela D Pack, Rick L Tarleton
July 2, 2020
Open Access

Venom alkaloids against Chagas disease parasite: search for effective therapies

Scientific Reports
Rafael C M Costa SilvaNorton Heise
June 24, 2020
Comment / Editorial
Open Access

The 14th of April, Past and Present

Tropical Medicine and Infectious Disease
Simone Petraglia Kropf, Nísia Trindade Lima
June 27, 2020

Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids

European Journal of Medicinal Chemistry
Fábio S FernandesFernando Coelho
July 3, 2020

Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review

Current Pharmaceutical Design
Sonaly Lima AlbinoRicardo Olímpio de Moura
June 27, 2020
Review

Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis

Archives of Disease in Childhood
Justin PennerHermione Lyall
July 3, 2020
Review
Open Access

Chagas Disease Infection Reactivation after Heart Transplant

Tropical Medicine and Infectious Disease
Maria da Consolação Vieira Moreira, José Renan Cunha-Melo
July 3, 2020
Review
Open Access

Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery

Genes
Arijit BhattacharyaChristopher Fernandez-Prada
July 2, 2020
Open Access

The use of the CALL Risk Score for predicting mortality in Brazilian heart failure patients

ESC Heart Failure
Marcelo Arruda NakazoneReinaldo Bulgarelli Bestetti
June 24, 2020
Open Access

Replication origin location might contribute to genetic variability in Trypanosoma cruzi

BMC Genomics
Christiane Bezerra de AraujoMaria Carolina Elias

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