Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

September 16, 2020
Open Access

Role of FAK signaling in chagasic cardiac hypertrophy

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Amanda R TucciMirian Claudia S Pereira
September 19, 2020
Open Access

Chagas disease: Performance analysis of immunodiagnostic tests anti-Trypanosoma cruzi in blood donors with inconclusive screening results

Hematology, Transfusion and Cell Therapy
Márcia M Ferreira-SilvaHelio Moraes-Souza
September 11, 2020

Circulating Trypanosoma Cruzi Load and Major Cardiovascular Outcomes in Patients with Chronic Chagas Cardiomyopathy: A Prospective Cohort Study

Tropical Medicine & International Health : TM & IH
Luis E EcheverríaCarlos A Morillo
September 2, 2020
Review
Open Access

The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
María Eugenia Giorgi, Rosa M de Lederkremer
September 15, 2020
Open Access

Management of Cardiovascular Disease Patients With Confirmed or Suspected COVID-19 in Limited Resource Settings

Global Heart
Dorairaj PrabhakaranKaren Sliwa
September 6, 2020
Review

May the Epimastigote Form of Trypanosoma cruzi be infective?

Acta Tropica
Wanderley de Souza, Emile S Barrias
September 3, 2020

Effect of exercise training on cardiovascular autonomic and muscular function in subclinical Chagas cardiomyopathy: a randomized controlled trial

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Adriana Oliveira SarmentoBarbara M Ianni
September 10, 2020

Production of Highly Active Antiparasitic Compounds from the Controlled Halogenation of the Arrabidaea brachypoda Crude Plant Extract

Journal of Natural Products
Alexandra NeuenschwanderEmerson F Queiroz
September 3, 2020
Open Access

Validation of a documentary on Chagas disease by a population living in an endemic area

Brazilian Journal of Biology = Revista Brasleira De Biologia
T F BianchiM M Villela
September 17, 2020
Open Access

Epidemiological profile of acute Chagas disease in individuals infected by oral transmission in northern Brazil

Revista Da Sociedade Brasileira De Medicina Tropical
George Harisson Felinto SampaioLúcia Maria da Cunha Galvão
September 21, 2020

Trypanosoma cruzi Importin α: ability to bind to a functional classical nuclear localization signal of the bipartite type

Parasitology Research
Israel Canela-PérezRoberto Hernández
September 2, 2020
Review
Open Access

Role of Melatonin in the Synchronization of Asexual Forms in the Parasite Plasmodium falciparum

Biomolecules
Maneesh Kumar SinghCélia R S Garcia
September 4, 2020
Open Access

Clinical, Cardiological and Serologic Follow-Up of Chagas Disease in Children and Adolescents from the Amazon Region, Brazil: Longitudinal Study

Tropical Medicine and Infectious Disease
Ana Yecê das Neves PintoAna Maria Revorêdo da Silva Ventura
September 17, 2020
Open Access

A systematic review of the diagnostic aspects and use of Trypanosoma rangeli as an immunogen for Trypanosoma cruzi infection

Revista Da Sociedade Brasileira De Medicina Tropical
Taciana de Souza BayãoRodrigo Siqueira-Batista
September 13, 2020

Azadirachtin interferes with basal immunity and microbial homeostasis in the Rhodnius prolixus midgut

Developmental and Comparative Immunology
Cecilia Stahl VieiraPatrícia Azambuja
September 18, 2020

Rapid Diagnostic Tests (RDTs) for Trypanosoma cruzi infection: field evaluation of two registered kits in an endemic and non-endemic region of Argentina

Journal of Clinical Microbiology
Constanza Lopez-AlbizuFavio Crudo

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