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Chagas Disease

Chagas Disease diagram by undefined

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

Top 20 most recent papers
Scientific Reports

Alteration of the aggregation and spatial organization of the vector of Chagas disease, Triatoma infestans, by the parasite Trypanosoma cruzi

Scientific ReportsNovember 22, 2019
Stéphanie DepickèreJean-Louis Deneubourg

Is vectorial transmission of Trypanosoma cruzi an efficient route to support high infection rates in sylvatic hosts?”

bioRxivNovember 29, 2019
Mauricio Santos-VegaFelipe Guhl
Scientific Reports

Analysis of mRNA processing at whole transcriptome level, transcriptomic profile and genome sequence refinement of Trypanosoma cruzi

Scientific ReportsNovember 22, 2019
Francisco Callejas-HernándezManuel F Fresno
Scientific Reports

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Scientific ReportsNovember 26, 2019
Dunia Margarita Medina-BuelvasLibia Vega

Phylobioactive hotspots identified through multidimensional profiling of botanical drugs used to treat Chagas disease in Bolivia and Dioscorides' De Materia Medica

bioRxivDecember 2, 2019
Andrea SalmJürg Gertsch
Angewandte Chemie

A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-trypanosomal Macrolides

Angewandte ChemieNovember 19, 2019
Matthew J AnketellIan Paterson
The Journal of Antimicrobial Chemotherapy

Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas' disease

The Journal of Antimicrobial ChemotherapyNovember 21, 2019
Yves L JacksonFrançois Chappuis
Acta Tropica

Interventions to Bring Comprehensive Care to People with Chagas Disease: Experiences in Bolivia, Argentina and Colombia

Acta TropicaDecember 4, 2019
María Jesús PinazoMauricio Javier Vera

Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease

TransfusionDecember 5, 2019
Paula Fraiman BlatytaNational Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study III (REDS-III) International Component, Brazil
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: A prospective cohort study in two Spanish referral centres

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious DiseasesNovember 15, 2019
Clara Crespillo-AndujarJosé Antonio Pérez-Molina
European Journal of Medicinal Chemistry

Hit-to-lead optimization of novel 2-alkylaminomethylquinoline derivatives as anti-chagas agents

European Journal of Medicinal ChemistryNovember 13, 2019
Gisela C MusciaFernanda María Frank
PLoS Neglected Tropical Diseases

Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

PLoS Neglected Tropical DiseasesNovember 21, 2019
Mariana StraussJavier Martín
BMC Public Health

Associations of mental disorders and neurotropic parasitic diseases: a meta-analysis in developing and emerging countries

BMC Public HealthDecember 5, 2019
Labanté Outcha DaréPierre-Marie Preux
Parasites & Vectors

Disentangling Trypanosoma cruzi transmission cycle dynamics through the identification of blood meal sources of natural populations of Triatoma dimidiata in Yucatán, Mexico

Parasites & VectorsNovember 29, 2019
Joel Israel Moo-MillanEtienne Waleckx
BioMed Research International

Sarcocystis spp. in Romanian Slaughtered Cattle: Molecular Characterization and Epidemiological Significance of the Findings

BioMed Research InternationalOctober 13, 2019
Kálmán ImreAdriana Morar
Journal of Chemical Information and Modeling

Discovery of Potent, Reversible and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach

Journal of Chemical Information and ModelingNovember 25, 2019
Mariana C SouzaAdriano Defini Andricopulo
European Journal of Medicinal Chemistry

Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities

European Journal of Medicinal ChemistryNovember 16, 2019
Francisco do Vale Chaves E MelloIsrael Felzenszwalb
Parasites & Vectors

Development and evaluation of a duplex TaqMan qPCR assay for detection and quantification of Trypanosoma cruzi infection in domestic and sylvatic reservoir hosts

Parasites & VectorsNovember 29, 2019
Diana Patricia WehrendtAlejandro Gabriel Schijman
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases

Economic costs of Chagas disease in Colombia in 2017: a social perspective

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious DiseasesNovember 23, 2019
Mario J Olivera, Giancarlo Buitrago
ACS Omega

Combining Charge Density Analysis with Machine Learning Tools To Investigate the Cruzain Inhibition Mechanism

ACS OmegaNovember 26, 2019
Adriano M LuchiNélida Maria Peruchena

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