Cholesterol in Inflammation & Remyelination

When demyelination occurs an inflammatory response is activated. Accumulation of excess myelin debris triggers cholesterol crystal formation, and cholesterol deposits in the CNS can overwhelm phagocytes, resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

August 24, 2021

Salsalate reduces atherosclerosis through AMPKβ1 in mice.

Molecular Metabolism
Emily A DayGregory R Steinberg
August 23, 2021

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.

The Journal of Experimental Medicine
Garyfallia GounaMikael Simons
August 21, 2021

Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.

Proceedings of the National Academy of Sciences of the United States of America
Catherine LarochelleFrauke Zipp
August 13, 2021
Open Access

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

BioRxiv : the Preprint Server for Biology
S. BerghoffGesine Saher
August 13, 2021

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.

Proceedings of the National Academy of Sciences of the United States of America
Hao WangScott B Hansen
August 5, 2021
Open Access

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of Cell Biology
Wan Yun HoShuo-Chien Ling
July 28, 2021

Characterization of Citrus Pectin Oligosaccharides and Their Microbial Metabolites as Modulators of Immunometabolism on Macrophages.

Journal of Agricultural and Food Chemistry
Haijuan HuSiyi Pan
July 26, 2021

Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jhih-Wei HsuTsui-Chun Tsou
June 19, 2021

EBI2 is expressed in glial cells in multiple sclerosis lesions, and its knock-out modulates remyelination in the cuprizone model.

The European Journal of Neuroscience
Ilona KlejborAleksandra Rutkowska
May 1, 2021
Open Access

Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

Frontiers in Endocrinology
Inés Pineda-TorraElizabeth C Jury

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