Cholesterol in Inflammation & Remyelination

The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

October 1, 2019
Open Access

Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression

Molecular Nutrition & Food Research
Juri C MatualatupauwJildau Bouwman
March 6, 2020

TREM2: Modulator of Lipid Metabolism in Microglia

Eyiyemisi C DamisahJaime Grutzendler
August 1, 2020
Open Access

Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis

Scientific Reports
Harry D DawsonJoseph F Urban
October 24, 2019
Open Access

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mona LeiAnthony S Don
September 10, 2019
Open Access

Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing

Subhoshree GhoseShantanu Sengupta
August 24, 2019

Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis

American Journal of Physiology. Heart and Circulatory Physiology
Qiying FanBradley K McConnell
August 1, 2020
Open Access

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

Frontiers in Medicine
Federica SaponaroGrazia Chiellini
July 16, 2020
Open Access

Altered Toxicological Endpoints in Humans with Quaternary Ammonium Compound Exposure

MedRxiv : the Preprint Server for Health Sciences
Terry C HrubecR. T. Williams
February 27, 2020
Open Access

Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations

Journal of Neuropathology and Experimental Neurology
Takashi KurashigeTsuyoshi Torii
July 19, 2020

Molecular insight into neurodegeneration - Langmuir monolayer study on the influence of oxysterols on model myelin sheath

The Journal of Steroid Biochemistry and Molecular Biology
Anna Chachaj-BrekieszPatrycja Dynarowicz-Latka
September 16, 2020

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Proceedings of the National Academy of Sciences of the United States of America
Alan SariolStanley Perlman
February 26, 2020
Open Access

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

The Journal of Experimental Medicine
Jeroen F J BogieJerome J A Hendriks
January 23, 2020

Lipid Profiling of Serum and Lipoprotein Fractions in Response to Pitavastatin Using an Animal Model of Familial Hypercholesterolemia

Journal of Proteome Research
Hiroaki TakedaTakeshi Bamba

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