Cholesterol Synthesis in Inflammation & Remyelination

The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

November 24, 2020
Open Access

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles forcholesterol delivery in Huntington disease

BioRxiv : the Preprint Server for Biology
Giulia BiroliniElena Cattaneo
December 23, 2020

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Nature Neuroscience
Stefan A BerghoffGesine Saher
July 6, 2020

DHA reduces hypothalamic inflammation and improves central leptin signaling in mice

Life Sciences
Licai ChengYinghua Yu
November 4, 2020
Open Access

Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia

The Journal of Clinical Investigation
Yi XieXinfeng Liu
January 16, 2021
Open Access

The Effect of Inflammation and Insulin Resistance on Lipid and Lipoprotein Responsiveness to Dietary Intervention

Current Developments in Nutrition
Kristina S PetersenPenny M Kris-Etherton
September 30, 2020

PCSK9 and LRP5 in macrophage lipid internalization and inflammation

Cardiovascular Research
Lina BadimonMaria Borrell-Pages
August 1, 2020
Open Access

Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis

Scientific Reports
Harry D DawsonJoseph F Urban
January 8, 2021

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Giulia BiroliniElena Cattaneo
August 1, 2020
Open Access

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

Frontiers in Medicine
Federica SaponaroGrazia Chiellini
July 16, 2020
Open Access

Altered Toxicological Endpoints in Humans with Quaternary Ammonium Compound Exposure

MedRxiv : the Preprint Server for Health Sciences
Terry C HrubecR. T. Williams
December 22, 2020
Open Access

Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain

Frontiers in Molecular Neuroscience
Nicolas DupréPhilippe Leroux
October 2, 2020
Open Access

Diverse Immunoregulatory Roles of Oxysterols-The Oxidized Cholesterol Metabolites

Chloe Choi, David K Finlay
December 1, 2020
Open Access

The potential of Atorvastatin for chronic lung diseases therapy

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Alaa S Tulbah
July 19, 2020

Molecular insight into neurodegeneration - Langmuir monolayer study on the influence of oxysterols on model myelin sheath

The Journal of Steroid Biochemistry and Molecular Biology
Anna Chachaj-BrekieszPatrycja Dynarowicz-Latka
January 19, 2021
Open Access

Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19.

Trends in Endocrinology and Metabolism : TEM
Yahya SohrabiRinesh Godfrey
September 16, 2020

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Proceedings of the National Academy of Sciences of the United States of America
Alan SariolStanley Perlman

Sign up to follow this feed and discover related papers.

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

© 2021 Meta ULC. All rights reserved