Cholesterol Synthesis in Inflammation & Remyelination

The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

October 1, 2019

Integrated Analys of High-Fat Challenge-Induced Changes in Blood Cell Whole-Genome Gene Expression

Molecular Nutrition & Food Research
Juri C MatualatupauwJildau Bouwman
March 6, 2020

TREM2: Modulator of Lipid Metabolism in Microglia

Neuron
Eyiyemisi C DamisahJaime Grutzendler
March 2, 2019
Open Access

Myelin: Methods for Purification and Proteome Analysis

Methods in Molecular Biology
Michelle S ErwigHauke B Werner
October 24, 2019
Open Access

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mona LeiAnthony S Don
February 19, 2019

Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP

Cell Chemical Biology
Dharmaraja AllimuthuDrew J Adams
September 10, 2019

Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing

Gene
Subhoshree GhoseShantanu Sengupta
August 24, 2019

Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis

American Journal of Physiology. Heart and Circulatory Physiology
Qiying FanBradley K McConnell
July 13, 2019

IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice

Toxicology and Applied Pharmacology
Ariel D QuirogaMaría C Carrillo
February 27, 2020
Open Access

Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations

Journal of Neuropathology and Experimental Neurology
Takashi KurashigeTsuyoshi Torii
February 26, 2020
Open Access

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

The Journal of Experimental Medicine
Jeroen F J BogieJerome J A Hendriks
January 23, 2020

Lipid Profiling of Serum and Lipoprotein Fractions in Response to Pitavastatin Using an Animal Model of Familial Hypercholesterolemia

Journal of Proteome Research
Hiroaki TakedaTakeshi Bamba
October 23, 2019
Review
Open Access

Atherosclerosis and Coenzyme Q10

International Journal of Molecular Sciences
Juan M Suárez-RiveroJosé A Sánchez-Alcázar
July 30, 2019

The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer

Current Opinion in Lipidology
Pallavi MukherjeeAlan M Fogelman
December 18, 2019
Open Access

The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina

Biomolecules
Alexey M PetrovIrina A Pikuleva

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