Cholesterol Synthesis in Inflammation & Remyelination

The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

January 13, 2022

The role of lipid metabolism in shaping the expansion and the function of regulatory T cells.

Clinical and Experimental Immunology
Alessandra Pinzon GrimaldosSilvia Piconese
December 11, 2021
Open Access

Neochlorogenic Acid Attenuates Hepatic Lipid Accumulation and Inflammation via Regulating miR-34a In Vitro.

International Journal of Molecular Sciences
Meng-Hsun YuChau-Jong Wang
December 6, 2021

Effect of Emodin on Hyperlipidemia and Hepatic Lipid Metabolism in Zebrafish Larvae Fed a High-Cholesterol Diet.

Chemistry & Biodiversity
Lin-Feng HeYun-Xia Li
December 3, 2021
Open Access

Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.

ELife
Drew WilfahrtVirginia Smith Shapiro
October 28, 2021

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.

Cell Reports
Stefan A BerghoffGesine Saher
October 7, 2021

Butyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring.

Pediatric Research
Maria E BarbianRheinallt M Jones
October 6, 2021

Targeting cholesterol homeostasis in hematopoietic malignancies.

Blood
Andrea Brendolan, Vincenzo Russo
August 24, 2021

Salsalate reduces atherosclerosis through AMPKβ1 in mice.

Molecular Metabolism
Emily A DayGregory R Steinberg
August 23, 2021

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.

The Journal of Experimental Medicine
Garyfallia GounaMikael Simons
August 21, 2021

Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation.

Proceedings of the National Academy of Sciences of the United States of America
Catherine LarochelleFrauke Zipp
August 13, 2021
Preprint
Open Access

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

BioRxiv : the Preprint Server for Biology
S. BerghoffGesine Saher
August 13, 2021

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.

Proceedings of the National Academy of Sciences of the United States of America
Hao WangScott B Hansen

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