Cholesterol Synthesis in Inflammation & Remyelination

The inflammatory response is activated when demyelination occurs. Accumulation of excess myelin debris triggers cholesterol crystal formation. Cholesterol deposits in the CNS can overwhelm phagocytes resulting in impaired tissue regeneration. Here is the latest research on cholesterol synthesis in inflammation and remyelination.

November 24, 2020
Preprint
Open Access

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles forcholesterol delivery in Huntington disease

BioRxiv : the Preprint Server for Biology
Giulia BiroliniElena Cattaneo
December 23, 2020

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Nature Neuroscience
Stefan A BerghoffGesine Saher
July 6, 2020

DHA reduces hypothalamic inflammation and improves central leptin signaling in mice

Life Sciences
Licai ChengYinghua Yu
November 4, 2020
Open Access

Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia

The Journal of Clinical Investigation
Yi XieXinfeng Liu
January 16, 2021
Open Access

The Effect of Inflammation and Insulin Resistance on Lipid and Lipoprotein Responsiveness to Dietary Intervention

Current Developments in Nutrition
Kristina S PetersenPenny M Kris-Etherton
September 30, 2020

PCSK9 and LRP5 in macrophage lipid internalization and inflammation

Cardiovascular Research
Lina BadimonMaria Borrell-Pages
August 1, 2020
Open Access

Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis

Scientific Reports
Harry D DawsonJoseph F Urban
January 8, 2021

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Giulia BiroliniElena Cattaneo
August 1, 2020
Review
Open Access

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

Frontiers in Medicine
Federica SaponaroGrazia Chiellini
July 16, 2020
Preprint
Open Access

Altered Toxicological Endpoints in Humans with Quaternary Ammonium Compound Exposure

MedRxiv : the Preprint Server for Health Sciences
Terry C HrubecR. T. Williams
December 22, 2020
Open Access

Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain

Frontiers in Molecular Neuroscience
Nicolas DupréPhilippe Leroux
October 2, 2020
Review
Open Access

Diverse Immunoregulatory Roles of Oxysterols-The Oxidized Cholesterol Metabolites

Metabolites
Chloe Choi, David K Finlay
December 1, 2020
Review
Open Access

The potential of Atorvastatin for chronic lung diseases therapy

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Alaa S Tulbah
July 19, 2020

Molecular insight into neurodegeneration - Langmuir monolayer study on the influence of oxysterols on model myelin sheath

The Journal of Steroid Biochemistry and Molecular Biology
Anna Chachaj-BrekieszPatrycja Dynarowicz-Latka
January 19, 2021
Open Access

Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19.

Trends in Endocrinology and Metabolism : TEM
Yahya SohrabiRinesh Godfrey
September 16, 2020

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Proceedings of the National Academy of Sciences of the United States of America
Alan SariolStanley Perlman

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