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Cis & Trans Regulatory Elements

Cis & Trans Regulatory Elements diagram by Juan Gaertner, Shutterstock
Juan Gaertner, Shutterstock

Cis-regulatory elements are regions DNA that regulate the transcription of neighbouring genes. Trans-regulatory elements are genomic loci that regulate the expression of distant genes. Here is the latest research on CREs and TREs.

Top 20 most recent papers
PLoS Genetics

Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

PLoS GeneticsJanuary 22, 2020
Gregory R KeeleTerrence S Furey
Nature

TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

NatureJanuary 10, 2020
Jie SuJoan Massagué
78
3
1
Molecular Cell

Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks

Molecular CellJanuary 19, 2020
Helen ZhuJüri Reimand
94
14
2
Genome Research

A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes

Genome ResearchJanuary 19, 2020
Lei ZhangWange Lu
1
bioRxiv

On the origin and evolution of RNA editing in metazoans

bioRxivJanuary 19, 2020
Qiye LiGuojie Zhang
8
Science

N6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

ScienceJanuary 18, 2020
Jun LiuChuan He
48
Nature Communications

Genomic programming of IRF4-expressing human Langerhans cells

Nature CommunicationsJanuary 18, 2020
Sofia SirventMarta E Polak
7
bioRxiv

Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

bioRxivJanuary 14, 2020
Dan LiangJason L Stein
39
bioRxiv

Convergent genetic architecture underlies parallel pelvic reduction in genetically highly structured stickleback species

bioRxivJanuary 17, 2020
Petri M KemppainenJuha Merila
3
BMC Plant Biology

Differential expression of IDA (INFLORESCENCE DEFICIENT IN ABSCISSION)-like genes in Nicotiana benthamiana during corolla abscission, stem growth and water stress

BMC Plant BiologyJanuary 22, 2020
Daniel VentimillaFrancisco R Tadeo
Communications Biology

The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice

Communications BiologyJanuary 18, 2020
Tomoko MinamizakiYuji Yoshiko
4
Nucleic Acids Research

Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium

Nucleic Acids ResearchJanuary 21, 2020
Jun LiPin-Xian Xu
2
Cancer Science

TFAP4-uORF coding 66aa inhibits the malignant behavior of glioma cells via suppressing TFAP4/LINC00520/miR-520f-3p feedback loop

Cancer ScienceJanuary 17, 2020
Yipeng WangYunhui Liu
bioRxiv

Characterising open chromatin identifies novel cis-regulatory elements important for paraxial mesoderm formation and axis extension

bioRxivJanuary 20, 2020
Gi Fay MokAndrea Munsterberg
Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology

The cellular stress response and temperature: Function, regulation, and evolution

Journal of Experimental Zoology. Part A, Ecological and Integrative PhysiologyJanuary 17, 2020
George N Somero
Journal of Bacteriology

Roles of TroA and TroR in metalloregulated growth and gene expression in Treponema denticola

Journal of BacteriologyJanuary 15, 2020
Prakaimuk SaraithongJ Christopher Fenno
1
Biotechnology Advances

Cyanobacterial sigma factors: Current and future applications for biotechnological advances

Biotechnology AdvancesJanuary 17, 2020
Amit SrivastavaRoman Sobotka
5
Planta

Generation of fruit postharvest gene datasets and a novel motif analysis tool for functional studies: uncovering links between peach fruit heat treatment and cold storage responses

PlantaJanuary 18, 2020
Mauro GismondiClaudia A Bustamante
bioRxiv

An ancient satellite repeat controls gene expression and embryonic development in Aedes aegypti through a highly conserved piRNA

bioRxivJanuary 15, 2020
Rebecca HalbachRonald P. van Rij
3
bioRxiv

Norway spruce deploys tissue specific canonical responses to acclimate to the cold

bioRxivJanuary 17, 2020
Alexander VergaraVaughan Hurry

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