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Classical Complement Pathway

Classical Complement Pathway diagram by Public Domain, Wikimedia
Public Domain, Wikimedia

The Classical Complement Pathway is activated by antigen-antibody complexes. Activation of this pathway leads to the generation of the membrane attack complex, which kills pathogenic cells. Discover the latest research on the Classical Complement Pathway here.

Top 20 most recent papers
Journal of the American Society of Nephrology : JASN

A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation

Journal of the American Society of Nephrology : JASNApril 3, 2020
Robert J EllisSusan J Jordan
Proceedings of the National Academy of Sciences of the United States of America

Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Proceedings of the National Academy of Sciences of the United States of AmericaApril 3, 2020
Subhash HaldarNeil A Bhowmick
The Journal of Immunology : Official Journal of the American Association of Immunologists

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury

The Journal of Immunology : Official Journal of the American Association of ImmunologistsApril 3, 2020
Sladjana Skopelja-GardnerKeith B Elkon

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

bioRxivMarch 26, 2020
Nazia AbbasiWendy Jia Men Huang
Autoimmunity Reviews

The role of complement activation in autoimmune liver disease

Autoimmunity ReviewsApril 3, 2020
Maaike BiewengaLeendert A Trouw
The Journal of Rheumatology

Advanced Chronic Kidney Disease in Lupus Nephritis: Is Dialysis Inevitable?

The Journal of RheumatologyApril 3, 2020
Konstantinos TseliosMurray B Urowitz
Investigative Ophthalmology & Visual Science

Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular Degeneration

Investigative Ophthalmology & Visual ScienceApril 2, 2020
Susanne G PondorferRobert P Finger
PloS One

Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease

PloS OneApril 3, 2020
Elisabetta MargiottaPiergiorgio Messa
Journal of Translational Medicine

Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants

Journal of Translational MedicineApril 3, 2020
Mohammad Afzal KhanDieter Clemens Broering
Frontiers in Immunology

Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin

Frontiers in ImmunologyApril 2, 2020
Matías L GiglioHoracio Heras
Cardiovascular and Interventional Radiology

Percutaneous MR-Guided Cryoablation of Low-Flow Vascular Malformation: Technical Feasibility, Safety and Clinical Efficacy

Cardiovascular and Interventional RadiologyApril 3, 2020
Pierre-Alexis AutrusseauAfshin Gangi
Forensic Science, Medicine, and Pathology

The manifestations of acid attacks (vitriolage or vitriolism)

Forensic Science, Medicine, and PathologyMarch 28, 2020
Roger W Byard

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