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Collaboration for AIDS Vaccine Discovery (CAVD)

Collaboration for AIDS Vaccine Discovery (CAVD) diagram by Schiffner et al, PLOS Pathogens
Schiffner et al, PLOS Pathogens

The Collaboration for AIDS Vaccine Discovery (CAVD) focuses on designing a variety of novel HIV vaccine candidates and advancing the most promising candidates to clinical trials. Follow this feed to stay up to date on this important research from the CAVD.

Top 20 most recent papers
Lancet

The complex challenges of HIV vaccine development require renewed and expanded global commitment

LancetDecember 7, 2019
Linda-Gail BekkerMargaret I Johnston
160
1
4
bioRxiv

Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models

bioRxivJanuary 3, 2020
Ming TianFrederick W Alt
13
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

Phase 1 HIV vaccine trial to evaluate the safety and immunogenicity of HIV subtype C DNA and MF59-adjuvanted subtype C Env protein

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of AmericaJanuary 5, 2020
Mina C HosseinipourJames Kublin
12
Journal of Virology

Neutralizing antibody induction by HIV-1 Envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin

Journal of VirologyDecember 20, 2019
Rajesh P RingeJohn P Moore
1
Cell Host & Microbe

Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-αβR-/- Mice

Cell Host & MicrobeNovember 1, 2019
Rafael A LaroccaDan H Barouch
19
8
Nature Communications

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

Nature CommunicationsJanuary 26, 2020
Rory HendersonS Munir Alam
6
bioRxiv

Maternal alum-adjuvanted recombinant HIV Env vaccine does not enhance autologous virus neutralization in HIV-infected pregnant women

bioRxivDecember 12, 2019
Eliza D. HompeSallie Permar
12
Science

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

ScienceDecember 7, 2019
Kevin O SaundersBarton F Haynes
105
5
1
4
The Journal of Experimental Medicine

JEM goes viral

The Journal of Experimental MedicineJanuary 22, 2020
Carl F NathanTeodoro Pulvirenti
8
1
Nature Immunology

Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth

Nature ImmunologyJanuary 22, 2020
Krishna M RoskinScott D Boyd
30
Science Advances

NS1 DNA vaccination protects against Zika infection through T cell-mediated immunity in immunocompetent mice

Science AdvancesDecember 18, 2019
B Grubor-BaukE J Gowans
40
14
2
bioRxiv

Antigen responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir

bioRxivJanuary 11, 2020
Pilar MendozaLillian B Cohn
12
bioRxiv

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

bioRxivNovember 2, 2019
Rory HendersonS Munir Alam
7
4
PLoS Pathogens

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

PLoS PathogensDecember 4, 2019
Celia C LaBrancheD C Montefiori
Nature Communications

CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

Nature CommunicationsNovember 4, 2019
Nicholas J MauriceMartin Prlic
22
17
JCI Insight

BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults

JCI InsightNovember 20, 2019
Srabanti RakshitAnnapurna Vyakarnam
3
3
Journal of Virology

Boosting with AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency

Journal of VirologyNovember 29, 2019
David EasterhoffG Ferrari
2
Frontiers in Immunology

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

Frontiers in ImmunologyJanuary 11, 2020
B PerdigueroM Esteban
2
PloS One

Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay

PloS OneJanuary 10, 2020
Angela NagelKlaus Überla
1
Vaccine

Engineering immunity for next generation HIV vaccines: The intersection of bioengineering and immunology

VaccineNovember 25, 2019
M Patricia D'SouzaDavid Rampulla
2

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