Coronavirus Host Entry

The entry of coronaviruses into susceptible host cells is mediated by the viral S (Spike) glycoprotein. This feed covers latest findings about this complex process and the ongoing research efforts into finding therapeutics that can target the viral Spike protein and hence disrupt virus-cell fusion.

January 5, 2021
Review
Open Access

Surveying the Side-Chain Network Approach to Protein Structure and Dynamics: The SARS-CoV-2 Spike Protein as an Illustrative Case

Frontiers in Molecular Biosciences
Anushka HalderSaraswathi Vishveshwara
January 15, 2021
Preprint
Open Access

Vimentin binds to SARS-CoV-2 spike protein and antibodies targeting extracellular vimentin block in vitro uptake of SARS-CoV-2 virus-like particles

BioRxiv : the Preprint Server for Biology
Łukasz SuprewiczAlison Patteson
January 8, 2021
Preprint
Open Access

Artemisia annua L. extracts prevent in vitro replication of SARS-CoV-2

BioRxiv : the Preprint Server for Biology
M S NairPamela Weathers
January 13, 2021

Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin

ACS Infectious Diseases
Tiffany TangGary R Whittaker
January 5, 2021
Open Access

Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein

Theranostics
Lin WangChunsheng Kang
January 6, 2021
Review
Open Access

The Two-Way Switch Role of ACE2 in the Treatment of Novel Coronavirus Pneumonia and Underlying Comorbidities

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiao Cong PangYi Zhun Zhu
January 5, 2021
Preprint
Open Access

Hydroxyzine inhibits SARS-CoV-2 Spike protein binding to ACE2 in a qualitative in vitro assay

BioRxiv : the Preprint Server for Biology
M. D. RivasJose Zamorano
January 6, 2021
Preprint
Open Access

N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation

ChemRxiv
Utsab DebnathAmit Mandal
January 14, 2021

Obesity and COVID-19: 2 The ominous duet affecting the renin-angiotensin system

Minerva endocrinologica
Livio LuziStefano Massarini
January 14, 2021
Open Access

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications

Science Signaling
Bálint MészárosToby J Gibson
January 14, 2021
Preprint
Open Access

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses

BioRxiv : the Preprint Server for Biology
G. W. CarnellJohn A. G. Briggs
January 12, 2021

Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections

Journal of Biomolecular Structure & Dynamics
Chavan SakshiV Veena
January 5, 2021
Review
Open Access

Current advances in the development of SARS-CoV-2 vaccines

International Journal of Biological Sciences
Annoor AwadasseidWen Zhang
January 6, 2021
Preprint
Open Access

Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2

BioRxiv : the Preprint Server for Biology
Vivek Govind KumarMahmoud Moradi
January 8, 2021
Preprint
Open Access

Human endemic coronavirus emergence in the context of past and recent zoonotic outbreaks

ResearchSquare
Diego ForniManuela Sironi
January 12, 2021
Review

Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients

Reviews in Medical Virology
Mohammad Mahmudur RahmanAsif Ahmed

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