Coronavirus Host Entry

The entry of coronaviruses into susceptible host cells is mediated by the viral S (Spike) glycoprotein. This feed covers latest findings about this complex process and the ongoing research efforts into finding therapeutics that can target the viral Spike protein and hence disrupt virus-cell fusion.

August 6, 2020
Open Access

Plasmapheresis, Anti-ACE2 and Anti-FcγRII Monoclonal Antibodies: A Possible Treatment for Severe Cases of COVID-19

Drug Design, Development and Therapy
Amin Sedokani, Sadegh Feizollahzadeh
August 6, 2020
Open Access

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Science
Kui K ChanErik Procko
August 2, 2020

Tumor markers as an entry for SARS-CoV-2 infection?

The FEBS Journal
Pu Xia, Anna Dubrovska
August 6, 2020

Role of key point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein

Infectious Disorders Drug Targets
Bipin Singh
August 6, 2020
Open Access

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients

Emerging Microbes & Infections
Cristina AndresJosep Quer
August 10, 2020
Open Access

COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Roger FrutosChristian A Devaux
August 2, 2020
Open Access

A thermostable, closed SARS-CoV-2 spike protein trimer

Nature Structural & Molecular Biology
Xiaoli XiongJohn A G Briggs
July 31, 2020
Open Access

Identification of an anti-SARS-CoV-2 receptor binding domain directed human monoclonal antibody from a naïve semi-synthetic library

The Journal of Biological Chemistry
Hilal Ahmed ParrayRajesh Kumar
July 29, 2020
Review
Open Access

Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials

International Journal of Molecular Sciences
Rami A Al-HoraniKholoud F Aliter
July 31, 2020
Open Access

COVID-19: Understanding the science of antibody testing and lessons from the HIV epidemic

Diagnostic Microbiology and Infectious Disease
Stanley H Weiss, Gary P Wormser
August 1, 2020
Open Access

Design of an engineered ACE2 as a novel therapeutics against COVID-19

Journal of Theoretical Biology
Zahra PayandehSaeed Khalili
July 31, 2020
Open Access

Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Natesh SinghBruno O Villoutreix
July 30, 2020
Open Access

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Nature
Jingyun YangXiawei Wei
August 10, 2020

Recent Discovery for Inhibitors Targeting in SARS-CoV-2 and Developed anti-NCP

Mini Reviews in Medicinal Chemistry
Mohd Faheem, Vinay K Singh
July 29, 2020
Preprint
Open Access

Structural and functional analysis of female sex hormones against SARS-Cov2 cell entry

BioRxiv : the Preprint Server for Biology
J. Aguilar PinedaChristian L Lino Cardenas

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