Coronavirus Host Entry

The entry of coronaviruses into susceptible host cells is mediated by the viral S (Spike) glycoprotein. This feed covers latest findings about this complex process and the ongoing research efforts into finding therapeutics that can target the viral Spike protein and hence disrupt virus-cell fusion.

January 21, 2022
Open Access

Exploring the Association Between Sialic Acid and SARS-CoV-2 Spike Protein Through a Molecular Dynamics-Based Approach.

Frontiers in Medical Technology
Leonardo BòGiancarlo Ruocco
January 20, 2022
Preprint
Open Access

NRP1 and furin as putative mediators of SARS-CoV-2 entry into human brain cells

BioRxiv : the Preprint Server for Biology
Ashutosh KumarP. Prasoon
January 19, 2022
Preprint
Open Access

High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

BioRxiv : the Preprint Server for Biology
J. J. SimsJames M Wilson
January 20, 2022

Designing of a bispecific antibody against SARS-CoV-2 spike glycoprotein targeting human entry receptors DPP4 and ACE2.

Human Immunology
Rupal OjhaVijay Kumar Prajapati
January 20, 2022

Inhibition of ACE2-Spike interaction by an ACE2 binder suppresses SARS-CoV-2 entry.

Angewandte Chemie
Young-Hee ShinSeung Bum Park
January 20, 2022

The "LLQY" motif on SARS-CoV-2 spike protein affects S incorporation into virus particles.

Journal of Virology
Shouwen DuChang Li
January 19, 2022

Heptad stereotypy, S/Q layering, and remote origin of the SARS-CoV-2 fusion core.

Virus Evolution
Chiara MarchettiFerdinando Fiumara
January 19, 2022
Open Access

Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In Vitro.

BioMed Research International
Palayakotai R Raghavan
January 19, 2022

RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern.

Chemical Communications : Chem Comm
Shi-Hao ZhouJun Guo
January 17, 2022

'All In One' SARS-CoV-2 variant recognition platform: Machine learning-enabled point of care diagnostics.

Biosensors & Bioelectronics: X
Duygu BedukSuna Timur
January 16, 2022

A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2.

Pharmacological Reports : PR
Kasi Pandima DeviHamid Reza Khayat Kashani
January 15, 2022
Open Access

The impact of calcitriol and estradiol on the SARS-CoV-2 biological activity: a molecular modeling approach.

Scientific Reports
Alireza MansouriAkio Miyamoto
January 15, 2022
Review

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?

Molecular Neurobiology
Theoharis C Theoharides
January 14, 2022

"But Mouse, You Are Not Alone": On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice.

ILAR Journal
Michael J KuiperSeshadri S Vasan
January 13, 2022
Preprint
Open Access

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2.

BioRxiv : the Preprint Server for Biology
Xuan YangTimothy M Willson
January 13, 2022
Preprint
Open Access

SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: clinical implications.

BioRxiv : the Preprint Server for Biology
L Vitale-CrossE Mezey
January 13, 2022

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases.

Journal of Virology
M Zeeshan ChaudhryLuka Cicin-Sain
January 12, 2022
Preprint
Open Access

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction

BioRxiv : the Preprint Server for Biology
E. A. AlbornozTrent M Woodruff

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