Coronavirus Protein Structures

Deciphering and comparing the proteins of different coronaviruses forms a basis for understanding SARS-CoV-2 evolution and virus-receptor interactions. This feed follows studies analyzing the structures of coronavirus proteins, thereby revealing potential drug target sites.

January 5, 2021
Review
Open Access

Surveying the Side-Chain Network Approach to Protein Structure and Dynamics: The SARS-CoV-2 Spike Protein as an Illustrative Case

Frontiers in Molecular Biosciences
Anushka HalderSaraswathi Vishveshwara
January 9, 2021
Open Access

D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction

Cell Reports
Sophie M-C GobeilPriyamvada Acharya
January 13, 2021
Open Access

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Nature Communications
Jiwan GeLinqi Zhang
January 6, 2021

ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4

Proceedings of the National Academy of Sciences of the United States of America
Robert G HammondMargaret A Johnson
January 13, 2021
Open Access

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

Nature Communications
Chao ZhangZhong Huang
December 29, 2020
Open Access

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

Proceedings of the National Academy of Sciences of the United States of America
Thomas G FlowerJames H Hurley
December 2, 2020
Open Access

Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Teresa L AugustinTaufiq Rahman
December 15, 2020
Preprint
Open Access

A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics

BioRxiv : the Preprint Server for Biology
J. GossenGiulia Rossetti
December 12, 2020
Open Access

Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease

Frontiers in Chemistry
Pietro DelreGiuseppe Felice Mangiatordi
December 28, 2020
Preprint
Open Access

Identification of Mutation Resistance Coldspots for Targeting the SARS-CoV2 Main Protease

ResearchSquare
Navaneethakrishnan Krishnamoorthy, Khalid Fakhro
December 17, 2020
Preprint
Open Access

Identification of SARS-CoV2 Main Protease Coldspots Suitable for Drug Targeting

ResearchSquare
Navaneethakrishnan Krishnamoorthy, Khalid Fakhro
January 6, 2021
Preprint
Open Access

Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2

BioRxiv : the Preprint Server for Biology
Vivek Govind KumarMahmoud Moradi
December 29, 2020
Open Access

DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes

Proceedings of the National Academy of Sciences of the United States of America
Jonas PfabDong Si
January 10, 2021
Open Access

Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Nature Communications
Xiyong SongGuiqing Peng
December 8, 2020
Preprint
Open Access

Molecular Modelling Reveals Eight Novel Druggable Binding Sites in SARS-CoV-2’s Spike Protein

ChemRxiv
Ilke Ugur Marion, Antoine Marion

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