CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

January 16, 2022
Review

C/EBPβ sustains the oncogenic program of AML cells by cooperating with MYB and co-activator p300 in a transcriptional module.

Experimental Hematology
Karl-Heinz Klempnauer
January 16, 2022

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatment.

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Marika SculcoIrma Dianzani
January 16, 2022
Open Access

Acute myeloid leukemia due to germline CEBPA mutation in a Syrian family.

Molecular Genetics & Genomic Medicine
Abdulsamad WafaWalid Al-Achkar
January 16, 2022
Review

Therapeutic benefits of flavonoids against neuroinflammation: a systematic review.

Inflammopharmacology
HamsalakshmiSaravana Babu Chidambaram
January 16, 2022

Enhancer-Addicted Prostate Cancer Is Sensitive to SWI/SNF Degradation.

Cancer Discovery
January 16, 2022

APOE4 genotype confers transcriptomic and functional alterations to primary mouse microglia.

Neurobiology of Disease
Saima I MachloviAlison M Goate
January 16, 2022

Anti-HBV drug entecavir ameliorates DSS-induced colitis through PD-L1 induction.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Yuichiro YamamotoAi Kotani
January 15, 2022

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy.

Nature Communications
Rafal CzapiewskiEric C Schirmer
January 15, 2022

Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome.

Nature Communications
Emily V DutrowJames P Noonan
January 15, 2022
Open Access

Oral streptococci subvert the host innate immune response through hydrogen peroxide.

Scientific Reports
Yi Ling TangKai Soo Tan
January 15, 2022

Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes.

Asian Journal of Pharmaceutical Sciences
Jiafu MuJianqing Gao
January 15, 2022
Review

[Biologics for connective tissue diseases and vasculitides].

Der Internist
Bernhard Hellmich, Joerg C Henes
January 15, 2022
Review

The role of metabolic ecosystem in cancer progression - metabolic plasticity and mTOR hyperactivity in tumor tissues.

Cancer Metastasis Reviews
Anna SebestyénGábor Petővári
January 15, 2022

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression.

Science Immunology
Ricardo N RamirezChristophe Benoist
January 15, 2022

A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1.

Blood
Leif LudwigVijay G Sankaran
January 15, 2022

Rapid and sensitive detection of PD-L1 exosomes using Cu-TCPP 2D MOF as a SPR sensitizer.

Biosensors & Bioelectronics
Yindian WangHongxia Chen
January 15, 2022

Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T cell leukemia/lymphoma.

Blood Advances
Anusara DaenthanasanmakThomas A Waldmann

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