CRISPR Genome Editing & Therapy (Preprints)

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.

April 18, 2021
Preprint
Open Access

Design of time-delayed safety switches for CRISPR gene therapy

BioRxiv : the Preprint Server for Biology
Dashan Sun
April 18, 2021
Preprint
Open Access

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

BioRxiv : the Preprint Server for Biology
M. Dos SantosPascal Maire
April 18, 2021
Preprint
Open Access

Genomic Stability and Genetic Defense Systems in Dolosigranulum pigrum a Candidate Beneficial Bacterium from the Human Microbiome

BioRxiv : the Preprint Server for Biology
S. Flores RamosKatherine P Lemon
April 17, 2021
Preprint
Open Access

Direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping (CasKAS)

BioRxiv : the Preprint Server for Biology
Georgi K MarinovW. J. Greenleaf
April 17, 2021
Preprint
Open Access

Precision Genome and Base Editing by Regulating mRNA Nuclear Export Using Selective Inhibitors of Nuclear Export

BioRxiv : the Preprint Server for Biology
Y. CuiJ. Liu
April 17, 2021
Preprint
Open Access

A programmable system to methylate and demethylate m6A on specific mRNAs

BioRxiv : the Preprint Server for Biology
C. ChangAndrew P Hutchins
April 17, 2021
Preprint
Open Access

Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies

BioRxiv : the Preprint Server for Biology
J. XuNorbert Perrimon
April 14, 2021
Preprint
Open Access

The TCP transcription factor HvTB2 heterodimerizes with VRS5(HvTB1) and controls spike architecture in barley

BioRxiv : the Preprint Server for Biology
T. de Souza MoraesWilma Gijsbert van Esse
April 14, 2021
Preprint
Open Access

A divergent nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential

BioRxiv : the Preprint Server for Biology
E. McHughStuart A. Ralph
April 13, 2021
Preprint
Open Access

Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

MedRxiv : the Preprint Server for Health Sciences
Silva KaselaT. Lappalainen
April 13, 2021
Preprint
Open Access

Comprehensive analysis of prime editing outcomes in human embryonic stem cells

BioRxiv : the Preprint Server for Biology
O. HabibSangsu Bae
April 12, 2021
Preprint
Open Access

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

BioRxiv : the Preprint Server for Biology
N.-V. MohamedThomas M. Durcan
April 12, 2021
Preprint
Open Access

Proteomic analysis of the role of the quality control protease LONP1 in mitochondrial protein aggregation

BioRxiv : the Preprint Server for Biology
K. PolleckerWolfgang Voos
April 12, 2021
Preprint
Open Access

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens

BioRxiv : the Preprint Server for Biology
Elizabeth PurseyS. van Houte
April 12, 2021
Preprint
Open Access

Inhibition of arenavirus entry and replication by the cell-intrinsic restriction factor ZMPSTE24 is enhanced by IFITM antiviral activity

BioRxiv : the Preprint Server for Biology
R. J. Stott, Toshana L Foster
April 12, 2021
Preprint
Open Access

In vivo genome-wide CRISPR screens identify SOCS1 as a major intrinsic checkpoint of CD4+ Th1 cell response

BioRxiv : the Preprint Server for Biology
A. Sutra Del GalyLaurie Menger
April 12, 2021
Preprint
Open Access

Normalisr: normalization and association testing for single-cell CRISPR screen and co-expression

BioRxiv : the Preprint Server for Biology
Lingfei Wang
April 12, 2021
Preprint
Open Access

CRISPR Knock-in Designer: automatic oligonucleotide design software to introduce point mutations using CRISPR/Cas9

BioRxiv : the Preprint Server for Biology
Sergey V PrykhozhijJ. Berman
April 9, 2021
Preprint
Open Access

Genetic mechanisms for tissue-specific essential genes

BioRxiv : the Preprint Server for Biology
E. DvirSagiv Shifman

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