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CRISPR Genome Editing & Therapy (Preprints)

CRISPR Genome Editing & Therapy (Preprints)   diagram by Kweon et al, PLOS One
Kweon et al, PLOS One

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.

Top 20 most recent papers
bioRxiv

Complex deletion and proximal reinsertion of a 150bp regulatory sequence in the mouse Csf1r promoter mediated by CRISPR-Cas9.

bioRxivDecember 11, 2019
Kim SummersDavid A Hume
19
bioRxiv

A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs

bioRxivDecember 18, 2019
Kenichi ShimadaTimothy J Mitchison
15
bioRxiv

Selective metabolic redundancy of Gpi1 allows for specific inhibition of inflammatory Th17 cells

bioRxivNovember 29, 2019
Lin WuDan R Littman
22
1
bioRxiv

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

bioRxivJanuary 14, 2020
Emanuel GoncalvesMathew J Garnett
73
bioRxiv

Extensive Mammalian Germline Genome Engineering

bioRxivDecember 22, 2019
Yanan YueLuhan Yang
195
2
1
bioRxiv

Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis

bioRxivDecember 13, 2019
Guislaine RefrégierChristophe Guyeux
8
bioRxiv

SNP-CRISPR: a web tool for SNP-specific genome editing

bioRxivNovember 19, 2019
Chiao-Lin ChenNorbert Perrimon
30
3
bioRxiv

A minimal CRISPR-Cas3 system for genome engineering

bioRxivDecember 3, 2019
Balint CsorgoJoseph Bondy-Denomy
83
bioRxiv

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

bioRxivDecember 20, 2019
Nidaa AbabnehKevin Talbot
20
bioRxiv

Mutations in the tomato gibberellin receptors suppresses xylem proliferation and reduces water loss under water-deficit conditions

bioRxivJanuary 6, 2020
Natanella Illouz-EliazDavid Weiss
26
bioRxiv

Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes

bioRxivNovember 18, 2019
Aditi KulkarniJiannong Xu
11
3
bioRxiv

ACE: A Probabilistic Model for Characterizing Gene-Level Essentiality in CRISPR Screens

bioRxivDecember 8, 2019
Elizabeth Hutton, Adam Siepel
21
bioRxiv

Ares-GT: design of guide RNAs targeting multiple genes for CRISPR-Cas experiments

bioRxivJanuary 13, 2020
Eugenio G. Minguet
16
1
bioRxiv

Science communication in online media: influence of press releases on coverage of genetics and CRISPR

bioRxivDecember 16, 2019
Rafał Grochala
8
bioRxiv

RNA-guided Retargeting of Sleeping Beauty Transposition in Human Cells

bioRxivNovember 20, 2019
Adrian KovačZoltán Ivics
7
3
bioRxiv

TUTase mediated site-directed access to clickable chromatin employing CRISPR-dCas9

bioRxivNovember 20, 2019
Jerrin Thomas GeorgeSeergazhi G Srivatsan
13
bioRxiv

Transient CRISPR immunity leads to coexistence with phages

bioRxivDecember 19, 2019
Sean MeadenEdze R Westra
43
bioRxiv

The AAA+ ATPase ClpX Is Critical for Growth and Development of Chlamydia trachomatis

bioRxivDecember 8, 2019
Nicholas A. WoodScot P Ouellette
5
bioRxiv

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity

bioRxivDecember 4, 2019
Ian GansJames A Coffman
3
bioRxiv

Machine Learning Predicts New Anti-CRISPR Proteins

bioRxivNovember 29, 2019
Simon EitzingerFayyaz ul Amir Afsar Minhas
15
1

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