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CRISPR Genome Editing & Therapy

CRISPR Genome Editing & Therapy diagram by Jiyeon Kweon et al
Jiyeon Kweon et al

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.

Top 20 most recent papers
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Significance of BRCA2 and RB1 co-loss in aggressive prostate cancer progression

Clinical Cancer Research : an Official Journal of the American Association for Cancer ResearchDecember 3, 2019
Goutam ChakrabortyPhilip W Kantoff
Nature Communications

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

Nature CommunicationsDecember 6, 2019
Hiroyuki MorisakaTomoji Mashimo
Nature Biotechnology

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

Nature BiotechnologyDecember 9, 2019
David N. NguyenAlexander Marson
Journal of the American Chemical Society

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic Acid Targets

Journal of the American Chemical SocietyDecember 4, 2019
Ying XiongYi Lu

A minimal CRISPR-Cas3 system for genome engineering

bioRxivDecember 3, 2019
Bálint CsörgoJoseph Bondy-Denomy
Scientific Reports

LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels

Scientific ReportsDecember 2, 2019
Jaakko T LeinonenElisabeth I M Widen

The AAA+ ATPase ClpX Is Critical for Growth and Development of Chlamydia trachomatis

bioRxivDecember 8, 2019
Nicholas A. WoodScot P Ouellette

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity

bioRxivDecember 4, 2019
I H GANSJames A. Coffman
Scientific Reports

Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a

Scientific ReportsDecember 2, 2019
Kunwadee PalasinWilaiwan Chotigeat

Efficient Homology-directed Repair with Circular ssDNA Donors

bioRxivDecember 5, 2019
Sukanya IyerScot A. Wolfe

Characterization, modelling and mitigation of gene expression burden in mammalian cells

bioRxivDecember 6, 2019
Timothy FreiVelia Siciliano
Plant Biotechnology Journal

Disruption of miRNA Sequences by TALENs and CRISPR/Cas9 Induces Varied Lengths of miRNA Production

Plant Biotechnology JournalDecember 10, 2019
Honghao BiBing Yang

A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases

NatureDecember 9, 2019
Senén D MendozaJoseph Bondy-Denomy
Proceedings of the National Academy of Sciences of the United States of America

CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 9, 2019
Joanna JackowAngela M. Christiano

Complex deletion and proximal reinsertion of a 150bp regulatory sequence in the mouse Csf1r promoter mediated by CRISPR-Cas9.

bioRxivDecember 11, 2019
Kim M. SummersDavid Arthur Hume
Nature Microbiology

A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity

Nature MicrobiologyDecember 9, 2019
Lucía M MalonePeter C Fineran
Nature Communications

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Nature CommunicationsDecember 9, 2019
Arijit BhattacharyaMarc Ouellette
Gene Therapy

The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model

Gene TherapyDecember 9, 2019
Weisong DuanChun-Yan Li
International Journal of Molecular Sciences

Dead Cas Systems: Types, Principles, and Applications

International Journal of Molecular SciencesNovember 30, 2019
Sergey BrezginVladimir P Chulanov
G3 : Genes - Genomes - Genetics

CRISPR/Cas9-Mediated Integration of Large Transgene into Pig CEP112 Locus

G3 : Genes - Genomes - GeneticsDecember 9, 2019
Guo-ling LiDe-Wu Liu

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