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CRISPR Genome Editing & Therapy

CRISPR Genome Editing & Therapy diagram by Kweon et al, PLOS One
Kweon et al, PLOS One

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of this system for gene editing and therapy in human diseases.

Top 20 most recent papers
bioRxiv

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

bioRxivJanuary 14, 2020
Emanuel GoncalvesMathew J Garnett
60
Nature Biotechnology

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Nature BiotechnologyJanuary 15, 2020
Marco JostJonathan S Weissman
117
1
Nature Genetics

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Nature GeneticsJanuary 9, 2020
Sankari NagarajanJason S Carroll
57
MSystems

Network-Based Prediction of Novel CRISPR-Associated Genes in Metagenomes

MSystemsJanuary 16, 2020
Jake L Weissman, Philip L F Johnson
12
bioRxiv

cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington Disease

bioRxivJanuary 9, 2020
Manish SharmaSrinivasa Subramaniam
5
Genes

Comparative Genomics Analysis of Lactobacillus ruminis from Different Niches

GenesJanuary 16, 2020
Shuo WangWei Chen
3
Genome Research

Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9

Genome ResearchJanuary 5, 2020
Daniel AgudeloYannick Doyon
14
bioRxiv

TOP the Transcription Orientation Pipeline and its use to investigate the transcription of non-coding regions: assessment with CRISPR direct repeats and intergenic sequences.

bioRxivJanuary 15, 2020
Kimberley HouenoussiChristine Pourcel
6
Biochemical Society Transactions

Characterization and applications of Type I CRISPR-Cas systems

Biochemical Society TransactionsJanuary 11, 2020
Claudio Hidalgo-Cantabrana, Rodolphe Barrangou
bioRxiv

Comparison of CRISPR and marker based methods for the engineering of phage T7

bioRxivJanuary 13, 2020
Aurelija M GrigonyteAndrew D Millard
6
G3 : Genes - Genomes - Genetics

Type I-F CRISPR-Cas Distribution and Array Dynamics in Legionella pneumophila

G3 : Genes - Genomes - GeneticsJanuary 16, 2020
Shayna R Deecker, Alexander W Ensminger
1
Communications Biology

The repurposing of type I-E CRISPR-Cascade for gene activation in plants

Communications BiologyJanuary 12, 2020
Joshua K YoungRodolphe Barrangou
Methods in Molecular Biology

Engineering Mutation Clones in Mammalian Cells with CRISPR/Cas9

Methods in Molecular BiologyJanuary 16, 2020
Zijun HuoRuiying Zhao
Current Microbiology

The Complete Genome of Emcibacter congregatus ZYLT , a Marine Bacterium Encoding a CRISPR-Cas 9 Immune System

Current MicrobiologyJanuary 11, 2020
Zhe ZhaoMin Wu
1
bioRxiv

CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi

bioRxivJanuary 14, 2020
Indra RouxYit-Heng Chooi
33
Oncotarget

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma

OncotargetJanuary 7, 2020
Adi ZhengChristian Widmann
Methods in Molecular Biology

Generation of IL17RB Knockout Cell Lines Using CRISPR/Cas9-Based Genome Editing

Methods in Molecular BiologyJanuary 16, 2020
Olivia HuYan Zhu
1
bioRxiv

Ares-GT: design of guide RNAs targeting multiple genes for CRISPR-Cas experiments

bioRxivJanuary 13, 2020
Eugenio G. Minguet
16
Nature Protocols

Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames

Nature ProtocolsJanuary 10, 2020
Xiaomin SiCaixia Gao
4
Journal of Bioethical Inquiry

Beyond Mendelian Genetics: Anticipatory Biomedical Ethics and Policy Implications for the Use of CRISPR Together with Gene Drive in Humans

Journal of Bioethical InquiryJanuary 5, 2020
Michael W Nestor, Richard L Wilson
15
1

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