CRISPR in Cancer

CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.

September 2, 2020

The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential

Biochimica Et Biophysica Acta. Reviews on Cancer
Gouri PandyaManoj Garg
September 1, 2020

Sustained activation of notch signaling maintains tumor-initiating cells in a murine model of liposarcoma

Cancer Letters
Pei-Chieh TienShihuan Kuang
August 23, 2020
Open Access

Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia

International Journal of Molecular Sciences
Meiying FengKai Wang
August 26, 2020
Open Access

Personalized Immuno-oncology

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Kewal K Jain
September 7, 2020

Adenoviral vectors for in vivo delivery of CRISPR-Cas gene editors

Journal of Controlled Release : Official Journal of the Controlled Release Society
Paul BoucherDavid T Curiel
August 23, 2020
Open Access

Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation

Communications Biology
Jin Woo ParkSang-Beom Seo
August 10, 2020
Open Access

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Vuk BortnikAdi Idris
September 10, 2020
Open Access

Functional classification of prostate cancer‑associated miRNAs through CRISPR/Cas9‑mediated gene knockout

Molecular Medicine Reports
Fu-Neng JiangWei-De Zhong
September 13, 2020
Open Access

Gene expression is stable in a complete CIB1 knockout keratinocyte model

Scientific Reports
Elias ImahornBettina Burger
August 26, 2020
Open Access

Germline biallelic MCM8 variants are associated with early-onset Lynch-like syndrome

JCI Insight
Mariano GolubickiSergi Castellví-Bel
August 11, 2020
Open Access

Ready for Repair? Gene Editing Enters the Clinic for the Treatment of Human Disease

Molecular Therapy. Methods & Clinical Development
Martijn P T ErnstW W M Pim Pijnappel
August 15, 2020
Open Access

Hypomethylation of the promoter region drives ectopic expression of TMEM244 in Sézary cells

Journal of Cellular and Molecular Medicine
Katarzyna IżykowskaGrzegorz K Przybylski
August 19, 2020
Open Access

Identification of Functional HLA-A*01 :01-Restricted EBV-LMP2-Specific T-cell Receptors

The Journal of Infectious Diseases
Wesley HuismanInge Jedema

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