CRISPR in Cancer

CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.

February 27, 2021

Genomic evolution and diverse models of systemic metastases in colorectal cancer.

Hai-Ning ChenZong-Guang Zhou
February 27, 2021
Open Access

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.

Scientific Reports
Shojiro KitajimaHiroyuki Kato
February 27, 2021
Open Access

FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma.

Clinical and Translational Medicine
Siwei WangRong Yin
February 27, 2021
Open Access

Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma.

Clinical and Translational Medicine
Chuanjie ZhangDanfeng Xu
February 27, 2021

In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer.

Zeyu ChenJunwei Shi
February 26, 2021
Open Access

Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants.

BMC Biology
Aiping DuanJingping Yang
February 26, 2021
Open Access

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.

Science Advances
Michela SerresiGaetano Gargiulo
February 26, 2021

Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy.

Signal Transduction and Targeted Therapy
Fengzhen MoXiaoling Lu
February 26, 2021
Open Access

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing.

Nature Communications
Jenny MattssonBjörn Nilsson
February 26, 2021

FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.

David MilewskiTanya V Kalin
February 26, 2021

Re-defining synthetic lethality by phenotypic profiling for precision oncology.

Cell Chemical Biology
Yevhen Akimov, Tero Aittokallio
February 25, 2021
Open Access

Chronos: a CRISPR cell population dynamics model

BioRxiv : the Preprint Server for Biology
J. M. DempsterJames McFarland
February 24, 2021

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.

Proceedings of the National Academy of Sciences of the United States of America
Kartik N RajagopalanChao Lu
February 24, 2021

Loss of 9p21 regulatory hub promotes kidney cancer progression by upregulating HOXB13.

Molecular Cancer Research : MCR
Maria Francesca BaiettiAnna A Sablina
February 24, 2021
Open Access

Natural Competence and Horizontal Gene Transfer in Campylobacter.

Current Topics in Microbiology and Immunology
Julia Carolin Golz, Kerstin Stingl

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