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Crispr In Malaria

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CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

Top 20 most recent papers
Science Translational Medicine

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Science Translational MedicineSeptember 18, 2019
Joost SchalkwijkKoen J Dechering
22
13
Nature Biotechnology

In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Nature BiotechnologySeptember 25, 2019
Lupeng YeSidi Chen
107
5
bioRxiv

High density Novel Wolbachia strains in Anopheles species from Guinea

bioRxivSeptember 24, 2019
Claire L. JeffriesThomas Walker
18
bioRxiv

Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in Toxoplasma gondii.

bioRxivAugust 24, 2019
Alex RozenbergL. David David Sibley
4
2
Scientific Reports

High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation

Scientific ReportsOctober 16, 2019
Chrysanthi TaxiarchiRoberto Galizi
26
Scientific Reports

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum

Scientific ReportsNovember 13, 2019
Hai T N BuiTill S Voss
bioRxiv

EXP1 is required for organization of the intraerythrocytic malaria parasite vacuole

bioRxivAugust 31, 2019
Timothy NesselJosh R. Beck
5
3
The Journal of Experimental Medicine

Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection

The Journal of Experimental MedicineOctober 28, 2019
Jing YangErol Fikrig
8
4
4
bioRxiv

Cas9-mediated gene-editing in the malaria mosquito Anopheles stephensi by ReMOT Control

bioRxivSeptember 19, 2019
Vanessa M. MaciasJason L. Rasgon
62
bioRxiv

A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters

bioRxivNovember 8, 2019
Barbara FasuloNikolai Windbichler
19
bioRxiv

An assessment of adult mosquito collection techniques for studying species abundance and diversity in Maferinyah, Guinea

bioRxivSeptember 23, 2019
Cintia Cansado UtrillaThomas Walker
9
MBio

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

MBioSeptember 17, 2019
Marta TibúrcioMoritz Treeck
42
2
BMC Medical Ethics

Informed consent and community engagement in open field research: lessons for gene drive science

BMC Medical EthicsJuly 27, 2019
Jerome Amir Singh
4
8
bioRxiv

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

bioRxivMay 24, 2019
Ming D LiOmar S. Akbari
41
Scientific Reports

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy

Scientific ReportsAugust 19, 2019
Ratna VeeramachaneniNalin S Thakker
15
7
Malaria Journal

Characterizing the molecular and metabolic mechanisms of insecticide resistance in Anopheles gambiae in Faranah, Guinea

Malaria JournalJuly 17, 2019
Caleb SticaLouisa Alexandra Messenger
7
12
The CRISPR Journal

Redkmer: An Assembly-Free Pipeline for the Identification of Abundant and Specific X-Chromosome Target Sequences for X-Shredding by CRISPR Endonucleases

The CRISPR JournalFebruary 1, 2018
Philippos Aris A. Papathanos, Nikolai Windbichler
6
1
19
Scientific Reports

Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

Scientific ReportsMarch 26, 2019
Federica BernardiniAndrea Crisanti
4
11
bioRxiv

Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes

bioRxivNovember 18, 2019
Aditi KulkarniJian-Nong Xu
6
ELife

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

ELifeJune 17, 2019
Franziska MohringRobert W Moon
36
27

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