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Crispr In Malaria

Crispr In Malaria diagram by Freakeistein, Shutterstock
Freakeistein, Shutterstock

CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

Top 20 most recent papers
bioRxiv

Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila

bioRxivDecember 13, 2019
Emilie PondevilleCatherine Bourgouin
29
Science Translational Medicine

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Science Translational MedicineSeptember 20, 2019
Joost SchalkwijkKoen J Dechering
22
13
17
bioRxiv

Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes

bioRxivNovember 18, 2019
Aditi KulkarniJiannong Xu
11
3
bioRxiv

Genome variation and population structure among 1,142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

bioRxivDecember 9, 2019
Chris S ClarksonDominic P Kwiatkowski
80
bioRxiv

Disrupting female flight in the vector Aedes aegypti

bioRxivDecember 2, 2019
Sarah O'Leary, Zach Adelman
18
Nature Biotechnology

In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Nature BiotechnologySeptember 25, 2019
Lupeng YeSidi Chen
112
5
114
Scientific Reports

High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation

Scientific ReportsOctober 18, 2019
Chrysanthi TaxiarchiRoberto Galizi
26
13
bioRxiv

A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters

bioRxivNovember 8, 2019
Barbara FasuloNikolai Windbichler
20
2
bioRxiv

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

bioRxivMay 24, 2019
Ming LiOmar S Akbari
41
1
Insects

Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by Aedes aegypti

InsectsJanuary 17, 2020
Adeline E WilliamsKen E Olson
MBio

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

MBioSeptember 19, 2019
Marta TibúrcioMoritz Treeck
42
2
24
bioRxiv

Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in Toxoplasma gondii.

bioRxivAugust 24, 2019
Alex RozenbergL David Sibley
4
9
bioRxiv

Resistance is futile: A CRISPR homing gene drive targeting a haplolethal gene

bioRxivMay 27, 2019
Jackson ChamperPhilipp W. Messer
22
12
Scientific Reports

Publisher Correction: Introgression of a synthetic sex ratio distortion system from Anopheles gambiae into Anopheles arabiensis

Scientific ReportsMay 23, 2019
Federica BernardiniAndrea Crisanti
4
bioRxiv

EXP1 is required for organization of the intraerythrocytic malaria parasite vacuole

bioRxivAugust 31, 2019
Timothy NesselJosh R Beck
5
3
bioRxiv

Cas9-mediated gene-editing in the malaria mosquito Anopheles stephensi by ReMOT Control

bioRxivSeptember 19, 2019
Vanessa M MaciasJason L Rasgon
62
10
bioRxiv

Confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

bioRxivApril 12, 2019
Héctor M. Sánchez C.John M Marshall
23
bioRxiv

High density Novel Wolbachia strains in Anopheles species from Guinea

bioRxivSeptember 24, 2019
Claire L JeffriesThomas Walker
18
4
bioRxiv

The abundance and diversity of West Nile virus mosquito vectors in two Regional Units of Greece during the onset of the 2018 transmission season

bioRxivAugust 15, 2019
Marina BisiaThomas Walker
5
Proceedings of the National Academy of Sciences of the United States of America

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 7, 2019
Alex RosenbergL David Sibley
12

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