CRISPR in Malaria

CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

January 14, 2022
Open Access

C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites.

PLoS Biology
Maria L SimõesGeorge Dimopoulos
January 14, 2022

Reversing insecticide resistance with allelic-drive in Drosophila melanogaster.

Nature Communications
Bhagyashree KaduskarEthan Bier
January 8, 2022
Comment / Editorial

An Introduction to Containment Recommendations for Gene Drive Mosquitoes and the Laboratory Rearing of Genetically Engineered Mosquitoes in Africa.

Vector Borne and Zoonotic Diseases
Stephen Higgs
December 28, 2021

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes.

Frontiers in Bioengineering and Biotechnology
Yehonatan AlcalayPhilippos Aris Papathanos
December 21, 2021

Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions.

The Journal of Physical Chemistry Letters
Pei QiaoArthur Laganowsky
December 16, 2021

Observation of Feshbach resonances between a single ion and ultracold atoms.

Pascal WeckesserTobias Schaetz
December 15, 2021

Genetic Control in Historical Perspective: The Legacy of India's Genetic Control of Mosquitoes Unit.

The Hastings Center Report
Rebecca Wilbanks
December 16, 2021

Investigating molecular mechanisms of insecticide resistance in the Eastern Democratic Republic of the Congo.

Malaria Journal
Janvier BandibaboneLouisa A Messenger
December 8, 2021
Open Access

Genomic insertion locus and Cas9 expression in the germline affect CRISPR/Cas9-based gene drive performance in the yellow fever mosquito Aedes aegypti

BioRxiv : the Preprint Server for Biology
William ReidAlexander W.E. Franz
December 5, 2021
Open Access

Identification of ATP2B4 regulatory element containing functional genetic variants associated with severe malaria

MedRxiv : the Preprint Server for Health Sciences
S. NisarPascal Rihet
December 4, 2021

The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Anie NaqviEmma J Crosbie
December 2, 2021
Open Access

CRISPR gene-drive systems based on Cas9 nickases promote super-Mendelian inheritance in Drosophila

BioRxiv : the Preprint Server for Biology
V. Lopez del AmoValentino M Gantz
December 2, 2021
Open Access

CRISPR-mediated knock-in of transgenes into the malaria vector Anopheles funestus.

G3 : Genes - Genomes - Genetics
Charlotte QuinnTony Nolan
November 27, 2021

Comparison of in vitro transformation efficiency methods for Plasmodium falciparum.

Molecular and Biochemical Parasitology
Siqi WangZhaoqing Yang
November 26, 2021

In vivo functional validation of the V402L voltage gated sodium channel mutation in the malaria vector An. gambiae.

Pest Management Science
Jessica WilliamsLinda Grigoraki
November 19, 2021

High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes.

G3 : Genes - Genomes - Genetics
Gerard TerradasEthan Bier
November 15, 2021
Open Access

Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements

BioRxiv : the Preprint Server for Biology
S. QuekEva Heinz
November 15, 2021
Open Access

Entropy in the molecular recognition of membrane protein-lipid interactions

Pei QiaoArthur Laganowsky
November 12, 2021

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.

The Journal of Biological Chemistry
Charlotte B SpliidThomas Mandel Clausen

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