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CRISPR in Malaria

CRISPR in Malaria diagram by Freakeistein, Shutterstock
Freakeistein, Shutterstock

CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

Top 20 most recent papers
PloS One

CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say

PloS OneNovember 13, 2019
Michelle E AndersonLuke Alphey
31
6
Proceedings of the National Academy of Sciences of the United States of America

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 7, 2019
Alex RosenbergL David Sibley
13
Proceedings of the National Academy of Sciences of the United States of America

Knockout of juvenile hormone receptor, Methoprene-tolerant, induces black larval phenotype in the yellow fever mosquito, Aedes aegypti

Proceedings of the National Academy of Sciences of the United States of AmericaOctober 2, 2019
Guan-Heng ZhuSubba Reddy Palli
3
17
Science Translational Medicine

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Science Translational MedicineSeptember 20, 2019
Joost SchalkwijkKoen J Dechering
21
13
23
bioRxiv

A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters

bioRxivNovember 8, 2019
Barbara FasuloNikolai Windbichler
19
2
The Journal of Experimental Medicine

Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection

The Journal of Experimental MedicineOctober 30, 2019
Jing YangErol Fikrig
8
4
5
6
Evolutionary Applications

Assessing connectivity despite high diversity in island populations of a malaria mosquito

Evolutionary ApplicationsJanuary 30, 2020
Christina M BergeyNora J Besansky
12
1
9
Cellular Microbiology

EXP1 is required for organization of EXP2 in the intraerythrocytic malaria parasite vacuole

Cellular MicrobiologyJanuary 29, 2020
Timothy NesselJosh R Beck
1

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