CRISPR in Malaria

CRISPR-Cas system enables the editing of genes to create or correct mutations. This technology is being investigated to combat malaria by targeting specific stretches of vector DNA and editing the genome at precise locations. Here is the latest research.

January 14, 2022
Open Access

C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites.

PLoS Biology
Maria L SimõesGeorge Dimopoulos
January 14, 2022

Reversing insecticide resistance with allelic-drive in Drosophila melanogaster.

Nature Communications
Bhagyashree KaduskarEthan Bier
January 8, 2022
Comment / Editorial

An Introduction to Containment Recommendations for Gene Drive Mosquitoes and the Laboratory Rearing of Genetically Engineered Mosquitoes in Africa.

Vector Borne and Zoonotic Diseases
Stephen Higgs
December 28, 2021

The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes.

Frontiers in Bioengineering and Biotechnology
Yehonatan AlcalayPhilippos Aris Papathanos
December 21, 2021

Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions.

The Journal of Physical Chemistry Letters
Pei QiaoArthur Laganowsky
December 16, 2021

Observation of Feshbach resonances between a single ion and ultracold atoms.

Nature
Pascal WeckesserTobias Schaetz
December 15, 2021

Genetic Control in Historical Perspective: The Legacy of India's Genetic Control of Mosquitoes Unit.

The Hastings Center Report
Rebecca Wilbanks
December 16, 2021

Investigating molecular mechanisms of insecticide resistance in the Eastern Democratic Republic of the Congo.

Malaria Journal
Janvier BandibaboneLouisa A Messenger
December 8, 2021
Preprint
Open Access

Genomic insertion locus and Cas9 expression in the germline affect CRISPR/Cas9-based gene drive performance in the yellow fever mosquito Aedes aegypti

BioRxiv : the Preprint Server for Biology
William ReidAlexander W.E. Franz
December 5, 2021
Preprint
Open Access

Identification of ATP2B4 regulatory element containing functional genetic variants associated with severe malaria

MedRxiv : the Preprint Server for Health Sciences
S. NisarPascal Rihet
December 4, 2021

The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Anie NaqviEmma J Crosbie
December 2, 2021
Preprint
Open Access

CRISPR gene-drive systems based on Cas9 nickases promote super-Mendelian inheritance in Drosophila

BioRxiv : the Preprint Server for Biology
V. Lopez del AmoValentino M Gantz
December 2, 2021
Open Access

CRISPR-mediated knock-in of transgenes into the malaria vector Anopheles funestus.

G3 : Genes - Genomes - Genetics
Charlotte QuinnTony Nolan
November 27, 2021

Comparison of in vitro transformation efficiency methods for Plasmodium falciparum.

Molecular and Biochemical Parasitology
Siqi WangZhaoqing Yang
November 26, 2021

In vivo functional validation of the V402L voltage gated sodium channel mutation in the malaria vector An. gambiae.

Pest Management Science
Jessica WilliamsLinda Grigoraki
November 19, 2021

High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes.

G3 : Genes - Genomes - Genetics
Gerard TerradasEthan Bier
November 15, 2021
Preprint
Open Access

Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements

BioRxiv : the Preprint Server for Biology
S. QuekEva Heinz
November 15, 2021
Preprint
Open Access

Entropy in the molecular recognition of membrane protein-lipid interactions

ChemRxiv
Pei QiaoArthur Laganowsky
November 12, 2021

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.

The Journal of Biological Chemistry
Charlotte B SpliidThomas Mandel Clausen

Sign up to follow this feed and discover related papers.

Related Feeds

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Artificial Cell Models

This feed focuses on biomimetrics, synthetic biology and bio- and tissue-engineering approaches used for modeling human diseases.

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

© 2022 Meta ULC. All rights reserved
/feed-previews/crispr-in-malaria/4927c546-c644-400e-b08f-bb5ec7b7b26b