CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

July 1, 2020

Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi

Antimicrobial Agents and Chemotherapy
Julianna Siciliano de AraújoMaria de Nazaré Correia Soeiro
July 8, 2020

Toward a single dose cure for Buruli ulcer

Antimicrobial Agents and Chemotherapy
Sangeeta S ThomasKevin Pethe
July 1, 2020
Open Access

Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis

Antimicrobial Agents and Chemotherapy
Samantha HaoCharles Langelier
July 8, 2020

Monoclonal Antibody Therapy Protects Pharmacologically Immunosuppressed Mice from Lethal Infection with Influenza B Virus

Antimicrobial Agents and Chemotherapy
Bindumadhav M MaratheElena A Govorkova
July 8, 2020

Use of a fluorescence-based assay to measure Escherichia coli membrane potential changes in high throughput

Antimicrobial Agents and Chemotherapy
M Ashley HudsonSteve W Lockless
July 9, 2020

Ecofriendly Biomolecule-Capped Bifidobacterium bifidum -Manufactured Silver Nanoparticles and Efflux Pump Genes Expression Alteration in Klebsiella pneumoniae

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Aghigh DolatabadiFatemeh Ashrafi
July 8, 2020
Open Access

Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women infected with Schistosoma japonicum

Antimicrobial Agents and Chemotherapy
Amaya L BustinduyWilliam W Hope
July 1, 2020

Prolonged exposure to β-lactam antibiotics reestablishes susceptibility of daptomycin-nonsusceptible Staphylococcus aureus to daptomycin

Antimicrobial Agents and Chemotherapy
Rachel E JensonWarren E Rose
July 8, 2020

Ethionamide population pharmacokinetic model and target attainment in multidrug-resistant tuberculosis

Antimicrobial Agents and Chemotherapy
Mohammad H Al-ShaerCharles A Peloquin
June 26, 2020

Super-enhancer acquisition drives oncogene expression in triple negative breast cancer

PloS One
Ryan RaisnerKaren E Gascoigne
June 27, 2020

Identification and Characterization of Salmonella Serovars Isolated from Pig Farms in Benin City, Edo State, Nigeria: One Health Perspective

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Isoken H IgbinosaEtinosa O Igbinosa
July 1, 2020

Population pharmacokinetics and target attainment of cefepime in critically ill patients and guidance for initial dosing

Antimicrobial Agents and Chemotherapy
Mohammad H Al-ShaerCharles A Peloquin
June 27, 2020
Open Access

CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma

Blood Advances
Poornima RamkumarMartin Kampmann
July 8, 2020

Characterization of large deletion mutants of Mycobacterium tuberculosis selected for isoniazid resistance

Antimicrobial Agents and Chemotherapy
Catherine VilchèzeWilliam R Jacobs

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