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CRISPR Screens in Drug Resistance
Jiyeon Kweon et alCRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.
Top 20 most recent papers
PFM-like, a novel family of subclass B2 metallo β-lactamase from Pseudomonas synxantha belonging to the Pseudomonas fluorescens complex
Antimicrobial Agents and ChemotherapyNovember 4, 2019
Laurent PoirelPatrice Nordmann
1
A standard numbering scheme for class C β-lactamases
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Andrew R MackRobert A. Bonomo
A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers
Antimicrobial Agents and ChemotherapyNovember 4, 2019
James S. McCarthyJörg J Möhrle
Defining Essential Enhancer for Pluripotent stem cells using Features Oriented CRISPR-Cas9 Screen
bioRxivNovember 12, 2019
Hao Fei WangYuin-Han Loh
13
Multiple Ascending Dose Phase 1 Clinical Study of Safety, Tolerability and Pharmacokinetics of CRS3123, a Narrow Spectrum Agent with Minimal Disruption of Normal Gut Microbiota
Antimicrobial Agents and ChemotherapyNovember 4, 2019
Barbara K LomeliNebojsa Janjic
2
Taurolidine-citrate lock solution for prevention of endoluminal central venous catheter infection in neutropenic hematological patients: a randomized, double-blind, placebo-controlled trial (TAURCAT)
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Carlota GudiolJordi Carratalà
Meropenem-Vaborbactam Activity against Carbapenem-Resistant Enterobacterales Isolates Collected in U.S. Hospitals During 2016-2018
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Mariana CastanheiraDee Shortridge
2
Human Antiviral Efficacy, Safety and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein: A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Challenge Study
Antimicrobial Agents and ChemotherapyNovember 11, 2019
John P DeVincenzoEdward Littler
3
Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses in Vitro and in Humanized Mice
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Franck AmblardRaymond Felix Schinazi
Improvement of the immunochromatographic NG-Test CARBA5 assay for the detection of IMP-variants previously undetected
Antimicrobial Agents and ChemotherapyNovember 4, 2019
Hervé VollandThierry Naas
1
In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Alexander J LepakDavid R Andes
1
Improved Antibiotic Prescribing within a Veterans Affairs Primary Care System through a Multifaceted Intervention Centered on Peer Comparison of Overall Antibiotic Prescribing Rates
Antimicrobial Agents and ChemotherapyNovember 4, 2019
Nathan R ShivelyBrooke K Decker
34
1
Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of blaCMY
Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and DiseaseNovember 18, 2019
Nilar SanNobumichi Kobayashi
Synergistic Activity of Fluoroquinolones Combining with Artesunate Against Multidrug-Resistant Escherichia coli
Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and DiseaseNovember 18, 2019
SiMin WeiJin-Gui Li
Target Controlled Infusion of cefepime in critically ill patients: single center experience
Antimicrobial Agents and ChemotherapyNovember 4, 2019
Stijn JonckheerePieter J Colin
Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies
Frontiers in GeneticsOctober 30, 2019
John M. MarshallOmar S. Akbari
Activity of Aerosolized Levofloxacin Against Burkholderia cepacia in a Mouse Chronic Lung Infection Model
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Mojgan Sabet, David C Griffith
Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Karina CalvopiñaMatthew B. Avison
Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis During Acute Pulmonary Exacerbation
Antimicrobial Agents and ChemotherapyNovember 4, 2019
James M KiddJoseph Levente Kuti
Biochemical Activity of Vaborbactam
Antimicrobial Agents and ChemotherapyNovember 11, 2019
Ruslan Tsivkovski, Olga Lomovskaya