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CRISPR Screens in Drug Resistance

CRISPR Screens in Drug Resistance diagram by Kweon et al, PLOS One
Kweon et al, PLOS One

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Top 20 most recent papers
Antimicrobial Agents and Chemotherapy

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Nicolas KiefferPatrice Nordmann
Nature Genetics

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Nature GeneticsJanuary 9, 2020
Sankari NagarajanJason S Carroll
57
Antimicrobial Agents and Chemotherapy

First occurrence of the OXA-198 carbapenemase in Enterobacterales

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Rémy A BonninThierry Naas
bioRxiv

Programmable and portable CRISPR-Cas transcriptional activation in bacteria

bioRxivJanuary 3, 2020
Hsing-I HoHarris H Wang
59
Antimicrobial Agents and Chemotherapy

Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus With Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Christopher R MillerAndrew D Berti
1
Antimicrobial Agents and Chemotherapy

Safety, tolerability, pharmacokinetics and antimalarial activity of the novel Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048 in healthy volunteers

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Phumla SinxadiKaren I Barnes
Antimicrobial Agents and Chemotherapy

CORRELATION OF LINEZOLID HAIR CONCENTRATIONS WITH PLASMA EXPOSURE IN PATIENTS WITH DRUG-RESISTANT TB

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Sean WassermanJohn Metcalfe
Antimicrobial Agents and Chemotherapy

Relationship between Vancomycin Minimum Inhibitory Concentration with Virulence Genes Expression and Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus (MSSA) Strains Isolated from Left-sided Endocarditis

Antimicrobial Agents and ChemotherapyJanuary 8, 2020
Juan M PericàsHospital Clinic Endocarditis Study Group
6
Antimicrobial Agents and Chemotherapy

Population Pharmacokinetics of Teicoplanin in Preterm and Term Neonates: is it Time for a New Dosing Regimen?

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
A KontouE Roilides
Antimicrobial Agents and Chemotherapy

Real-world experience with ceftolozane-tazobactam for multidrug-resistant gram-negative bacterial infections

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Sarah C J JorgensenMichael J Rybak
5
Antimicrobial Agents and Chemotherapy

Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution is highly effective in vitro for Eradication of Candida auris Biofilms

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Ruth A ReitzelIssam I Raad
7
1
Antimicrobial Agents and Chemotherapy

Suppression of β-Lactam Resistance by Aspergillomarasmine A is Influenced by Both the Metallo-β-Lactamase Target and the Antibiotic Partner

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Caitlyn M RotondoGerard D Wright
4
Antimicrobial Agents and Chemotherapy

Mechanisms of acquired in vivo and in vitro resistance to voriconazole by Candida krusei following exposure to suboptimal drug concentration

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Elisabete RicardoCidália Pina-Vaz
6
Antimicrobial Agents and Chemotherapy

Dalbavancin and wound healing: new evidences/insights in a mouse model of skin infection

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Oriana SimonettiOscar Cirioni
Antimicrobial Agents and Chemotherapy

In vitro Evaluation of Antifungal Drug Combinations against Multidrug-resistant Candida auris isolates from New York Outbreak

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Brittany O'BrienVishnu Chaturvedi
25
Antimicrobial Agents and Chemotherapy

Antimalarial drug resistance profiling of Plasmodium falciparum infections in Ghana using molecular inversion probes and next generation sequencing

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Benedicta A MensahAnita Ghansah
Antimicrobial Agents and Chemotherapy

Drug development against smallpox: present and future

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Déborah Delaune, Frederic Iseni
2
Antimicrobial Agents and Chemotherapy

Evaluating accuracy of microsatellite markers for classification of recurrent infections during routine monitoring of anti-malarial drug efficacy: A computer modelling approach

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Sam JonesIan M Hastings
Antimicrobial Agents and Chemotherapy

Tryptophan trimers and tetramers inhibit dengue and Zika virus replication by interfering with viral attachment processes

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Antonios FikatasDominique Schols
1
Antimicrobial Agents and Chemotherapy

Sub-Inhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Up-regulating cidA

Antimicrobial Agents and ChemotherapyJanuary 15, 2020
Ye JinFangyou Yu

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