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CRISPR Screens in Drug Resistance

CRISPR Screens in Drug Resistance diagram by Jiyeon Kweon et al
Jiyeon Kweon et al

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Top 20 most recent papers
Antimicrobial Agents and Chemotherapy

PFM-like, a novel family of subclass B2 metallo β-lactamase from Pseudomonas synxantha belonging to the Pseudomonas fluorescens complex

Antimicrobial Agents and ChemotherapyNovember 4, 2019
Laurent PoirelPatrice Nordmann
1
Antimicrobial Agents and Chemotherapy

A standard numbering scheme for class C β-lactamases

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Andrew R MackRobert A. Bonomo
Antimicrobial Agents and Chemotherapy

A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

Antimicrobial Agents and ChemotherapyNovember 4, 2019
James S. McCarthyJörg J Möhrle
bioRxiv

Defining Essential Enhancer for Pluripotent stem cells using Features Oriented CRISPR-Cas9 Screen

bioRxivNovember 12, 2019
Hao Fei WangYuin-Han Loh
13
Antimicrobial Agents and Chemotherapy

Multiple Ascending Dose Phase 1 Clinical Study of Safety, Tolerability and Pharmacokinetics of CRS3123, a Narrow Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

Antimicrobial Agents and ChemotherapyNovember 4, 2019
Barbara K LomeliNebojsa Janjic
2
Antimicrobial Agents and Chemotherapy

Taurolidine-citrate lock solution for prevention of endoluminal central venous catheter infection in neutropenic hematological patients: a randomized, double-blind, placebo-controlled trial (TAURCAT)

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Carlota GudiolJordi Carratalà
Antimicrobial Agents and Chemotherapy

Meropenem-Vaborbactam Activity against Carbapenem-Resistant Enterobacterales Isolates Collected in U.S. Hospitals During 2016-2018

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Mariana CastanheiraDee Shortridge
2
Antimicrobial Agents and Chemotherapy

Human Antiviral Efficacy, Safety and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein: A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Challenge Study

Antimicrobial Agents and ChemotherapyNovember 11, 2019
John P DeVincenzoEdward Littler
3
Antimicrobial Agents and Chemotherapy

Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses in Vitro and in Humanized Mice

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Franck AmblardRaymond Felix Schinazi
Antimicrobial Agents and Chemotherapy

Improvement of the immunochromatographic NG-Test CARBA5 assay for the detection of IMP-variants previously undetected

Antimicrobial Agents and ChemotherapyNovember 4, 2019
Hervé VollandThierry Naas
1
Antimicrobial Agents and Chemotherapy

In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Alexander J LepakDavid R Andes
1
Antimicrobial Agents and Chemotherapy

Improved Antibiotic Prescribing within a Veterans Affairs Primary Care System through a Multifaceted Intervention Centered on Peer Comparison of Overall Antibiotic Prescribing Rates

Antimicrobial Agents and ChemotherapyNovember 4, 2019
Nathan R ShivelyBrooke K Decker
34
1
Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease

Genetic Diversity of CMY Beta-Lactamase Genes in Clinical Isolates of Escherichia coli in Myanmar: Identification of Three Novel Types and Updated Phylogenetic Classification of blaCMY

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and DiseaseNovember 18, 2019
Nilar SanNobumichi Kobayashi
Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease

Synergistic Activity of Fluoroquinolones Combining with Artesunate Against Multidrug-Resistant Escherichia coli

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and DiseaseNovember 18, 2019
SiMin WeiJin-Gui Li
Antimicrobial Agents and Chemotherapy

Target Controlled Infusion of cefepime in critically ill patients: single center experience

Antimicrobial Agents and ChemotherapyNovember 4, 2019
Stijn JonckheerePieter J Colin
Frontiers in Genetics

Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies

Frontiers in GeneticsOctober 30, 2019
John M. MarshallOmar S. Akbari
Antimicrobial Agents and Chemotherapy

Activity of Aerosolized Levofloxacin Against Burkholderia cepacia in a Mouse Chronic Lung Infection Model

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Mojgan Sabet, David C Griffith
Antimicrobial Agents and Chemotherapy

Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Karina CalvopiñaMatthew B. Avison
Antimicrobial Agents and Chemotherapy

Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis During Acute Pulmonary Exacerbation

Antimicrobial Agents and ChemotherapyNovember 4, 2019
James M KiddJoseph Levente Kuti
Antimicrobial Agents and Chemotherapy

Biochemical Activity of Vaborbactam

Antimicrobial Agents and ChemotherapyNovember 11, 2019
Ruslan Tsivkovski, Olga Lomovskaya

See more papers from this feed

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