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CRISPR Screens in Virology

CRISPR Screens in Virology diagram by Tan et al, PLOS One
Tan et al, PLOS One

This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that affect virus-host interactions. Here is the latest research.

Top 20 most recent papers
Cell

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

CellNovember 14, 2019
Tsz-Leung ToVamsi K. Mootha
209
4
49
1
Nature Communications

Ranking of non-coding pathogenic variants and putative essential regions of the human genome

Nature CommunicationsNovember 20, 2019
Alex WellsJulia Di Iulio
88
21
bioRxiv

A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in embryonic stem cells

bioRxivNovember 22, 2019
Matthew C. CanverPartha Pratim Das
8
bioRxiv

Genome-wide profiling of druggable active tumor defense mechanisms to enhance cancer immunotherapy

bioRxivNovember 15, 2019
Rigel Joseph KishtonNicholas P. Restifo
32
1
7
Cell

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER

CellNovember 19, 2019
Robert Thomas SchinzelAndrew G Dillin
93
2
bioRxiv

De novo assembly and characterization of transcriptome towards understanding molecular mechanism associated with MYMIV-resistance in Vigna mungo - A computational study

bioRxivNovember 16, 2019
Manoj Kumar GuptaLambodar Behera
4
Oncogene

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer

OncogeneDecember 10, 2019
Hilal SaraçNathan A Lack
bioRxiv

ACE: A Probabilistic Model for Characterizing Gene-Level Essentiality in CRISPR Screens

bioRxivDecember 8, 2019
Elizabeth R. Hutton, Adam C Siepel
21
Scientific Reports

Evolutionary conserved compositional structures hidden in genomes of the foot-and-mouth disease virus and of the human rhinovirus

Scientific ReportsNovember 12, 2019
Miguel Angel FuertesCarlos Alonso
Science Advances

Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy

Science AdvancesNovember 1, 2019
J-M HeoJ Wade Harper
Nature Methods

Time-resolved imaging-based CRISPRi screening

Nature MethodsNovember 18, 2019
Daniel CamsundJohan Elf
92
8
42
bioRxiv

ETV7 represses a subset of interferon-stimulated genes that restrict influenza viruses

bioRxivNovember 21, 2019
Heather M FroggattNicholas S Heaton
18
Nature Communications

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

Nature CommunicationsNovember 28, 2019
Ricky M TriggSuzanne Dawn Turner
21
3
Cancer Discovery

In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Cancer DiscoveryNovember 19, 2019
Fei LiKwok-Kin Wong
26
Nature Communications

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD

Nature CommunicationsNovember 29, 2019
Yeliz Yuva-AydemirFen-Biao Gao
12
1
bioRxiv

SAFB2 enables the processing of suboptimal stem-loop structures in clustered primary miRNA transcripts

bioRxivNovember 29, 2019
Katharina HutterSebastian Herzog
14
Proceedings of the National Academy of Sciences of the United States of America

Deciphering essential cistromes using genome-wide CRISPR screens

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 14, 2019
Teng FeiMyles A Brown
6
3
12
bioRxiv

Minimal genome-wide human CRISPR-Cas9 library

bioRxivNovember 21, 2019
Emanuel GonçalvesMathew J. Garnett
56
9
Nature Communications

Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

Nature CommunicationsDecember 2, 2019
Sun-Wang XuJian W J Wang
9
bioRxiv

Minimized double guide RNA libraries enable scale-limited CRISPR/Cas9 screens

bioRxivNovember 29, 2019
Elin Madli PeetsLeopold Parts
63

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