CRISPR & Single Cell Analyses

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on CRISPR-Cas applications relevant to single cell analyses. Here is the latest research.

May 28, 2020

Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice

Proceedings of the National Academy of Sciences of the United States of America
Bo ChenRafael L Ufret-Vincenty
April 18, 2020
Open Access

A20 and RBX1 regulate brentuximab vedotin sensitivity in Hodgkin Lymphoma models

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Wei WeiYibin Yang
May 13, 2020

Multiplex digital spatial profiling of proteins and RNA in fixed tissue

Nature Biotechnology
Christopher R MerrittJoseph M Beechem
April 24, 2020
Open Access

Consistent RNA sequencing contamination in GTEx and other data sets

Nature Communications
Tim O NieuwenhuisMarc K Halushka
May 21, 2020

T Cell Receptor Engineered Lymphocytes for Cancer Therapy

Current Protocols in Immunology
Meagan R RollinsIngunn M Stromnes
April 17, 2020
Open Access

Megakaryocyte and Platelet Transcriptomics for Discoveries in Human Health and Disease

Arteriosclerosis, Thrombosis, and Vascular Biology
Pavel Davizon-CastilloMatthew T Rondina
May 28, 2020
Open Access

SCSIM: Jointly simulating correlated single-cell and bulk next-generation DNA sequencing data

BMC Bioinformatics
Collin GiguerePatrick Flaherty
March 30, 2020
PreprintOpen Access

HIV-1 promoter is gradually silenced when integrated into BACH2

bioRxiv
Anne InderbitzinKarin J Metzner
April 21, 2020
Open Access

Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9-based screening system

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yung Wen ChiuTaisuke Tomita

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