CRISPRi Screens for Antibiotics

The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.

December 3, 2021

Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?

Cancer Research
Francisca Vazquez, William R Sellers
December 1, 2021

Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.

Cell Stem Cell
Rosemarie UngrichtPhilipp S Hoppe
November 29, 2021
Preprint
Open Access

Random clonal expansion as a limiting factor in transplantable in vivo CRISPR/Cas9 screens

BioRxiv : the Preprint Server for Biology
T. W. LeeStephen MF Jamieson
November 29, 2021

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Elizabeth PurseyStineke van Houte
November 28, 2021
Review
Open Access

CRISPR Screening: Molecular Tools for Studying Virus-Host Interactions.

Viruses
Vladimir ChulanovDmitry Kostyushev
November 27, 2021

Gene editing enables rapid engineering of complex antibiotic assembly lines.

Nature Communications
Wei Li ThongJason Micklefield
November 26, 2021

Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos.

Nature Communications
Raghuvir ViswanathaNorbert Perrimon
November 26, 2021

CRISPR inactivation by integration.

Nature Microbiology
Joseph Bondy-Denomy
November 26, 2021

Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes.

Nature Microbiology
Andrew VarbleLuciano A Marraffini
November 26, 2021

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.

Nature
Yuqing FengAlberto Martin
November 26, 2021
Review

Novel Biorecognition Elements against Pathogens in the Design of State-of-the-Art Diagnostics.

Biosensors
Maria G SandeLigia R Rodrigues
November 26, 2021
Review

Research on the drug resistance mechanism of foodborne pathogens.

Microbial Pathogenesis
Hengwei GeXihong Zhao
November 25, 2021
Preprint
Open Access

Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

BioRxiv : the Preprint Server for Biology
Kelsey VossJeffrey C Rathmell
November 25, 2021

Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in Adult T-cell leukemia/lymphoma.

Blood
Takashi IshioMasao Nakagawa
November 24, 2021

Click chemistry-enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.

Proceedings of the National Academy of Sciences of the United States of America
Timothy W BumpusJeremy M Baskin
November 22, 2021

Genomic insights of Acinetobacter baumannii ST374 reveal wide and increasing resistome and virulome.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Nayara Helisandra FedrigoMaria Cristina Bronharo Tognim
November 23, 2021
Review

3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction.

Neuronal Signaling
Geoffrey PotjewydNigel M Hooper

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