Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

September 11, 2020
Open Access

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Science
Longxing CaoDavid Baker
September 12, 2020

Structural basis for the inhibition of cGAS by nucleosomes

Science
Tomoya KujiraiHitoshi Kurumizaka
September 15, 2020

Roles of Variable Linker Length in Dual Acting Virucidal Entry Inhibitors on HIV-1 Potency via On-the-fly Free Energy Molecular Simulations

Protein Science : a Publication of the Protein Society
Steven T GossertCameron F Abrams
September 11, 2020

Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

Molecular Cell
Melanie A McDowellIrmgard Sinning
September 16, 2020
Open Access

Structure and Function of Stator Units of the Bacterial Flagellar Motor

Cell
Mònica SantiveriNicholas M I Taylor
September 14, 2020
Review

Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis

Biophysical Journal
Mengyu Wu, Gabriel C Lander
September 16, 2020
Review
Open Access

Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Danuta Witkowska
September 15, 2020

Thermally induced structural organization of nanodiscs by coarse-grained molecular dynamics simulations

Biophysical Chemistry
Warin RangubpitPornthep Sompornpisut
September 11, 2020
Open Access

Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay

Proceedings of the National Academy of Sciences of the United States of America
Glenn C CapodagliMatthew B Neiditch
September 17, 2020

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

Science Advances
Ching-Shin HuangZhulun Wang
September 16, 2020
Open Access

Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

ELife
James E CollierKim A Nasmyth
September 13, 2020
Review

Nucleosomes Meet Their Remodeler Match

Trends in Biochemical Sciences
Jonathan Markert, Karolin Luger
September 16, 2020

Looking back and looking forward: contributions of electron microscopy to the structural cell biology of gametes and fertilization

Open Biology
Ravi Teja RaviTzviya Zeev-Ben-Mordehai
September 14, 2020
Preprint
Open Access

High yield preparation of outer-membrane protein efflux pumps by in vitro refolding is concentration dependent

BioRxiv : the Preprint Server for Biology
S. J. BudiardjoJoanna Sarah Gershkoff Slusky
September 14, 2020
Review
Open Access

The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies

IScience
Marcel KnossowBenoît Gigant

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