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CZI Neurodegeneration Challenge Network (MDS)

CZI Neurodegeneration Challenge Network (MDS) diagram by Frank Gaillard, Wikimedia
Frank Gaillard, Wikimedia

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

Top 20 most recent papers
Nature Medicine

Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration

Nature MedicineMarch 4, 2020
Elisabeth H ThijssenAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators

A Deep Learning Approach to Antibiotic Discovery

CellFebruary 22, 2020
Jonathan M StokesJames J Collins
Nature Medicine

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

Nature MedicineMarch 13, 2020
Nicolas R BarthélemyDominantly Inherited Alzheimer Network

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

bioRxivMarch 26, 2020
Nazia AbbasiWendy Jia Men Huang

Neuro-immune Interactions in the Tissues

ImmunityMarch 19, 2020
Coco ChuIsaac M Chiu
The Journal of Investigative Dermatology

Artificial Intelligence in Dermatology: A Primer

The Journal of Investigative DermatologyApril 2, 2020
Albert T YoungMaria L Wei
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Deciphering the factors that influence participation in studies requiring serial lumbar punctures

Alzheimer's & Dementia : Diagnosis, Assessment & Disease MonitoringMarch 27, 2020
Gregory S DayJohn C Morris
Nature Reviews. Neuroscience

Publisher Correction: Tissue clearing and its applications in neuroscience

Nature Reviews. NeuroscienceMarch 11, 2020
Hiroki R UedaPhilipp J Keller

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Allen Institute for Brain Science Network (MDS)

The Allen Institute for Brain Science Network is a not-for-profit biomedical research organization that provides open access to multiple neuroscience tools and resources. Find the latest research from tjr Allen Institute for Brain Science Network here.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alpha-Synuclein Antibody Therapeutics (MDS)

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. They have also been detected in several other neurodegenerative diseases, known as synucleopathies. Here is the latest research on alpha-synuclein antibody therapeutics.

Astrocytes & Huntington’s Disease (MDS)

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Autophagy: Cancer & Parkinson (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in cancer and Parkinson’s.

BRAIN Initiative Cell Census Network (MDS)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

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