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CZI Neurodegeneration Challenge Network

CZI Neurodegeneration Challenge Network diagram by Frank Gaillard, Wikimedia
Frank Gaillard, Wikimedia

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

Top 20 most recent papers
bioRxiv

Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants

bioRxivDecember 12, 2019
Chongyuan LuoJoseph R. Ecker
65
bioRxiv

Extensive Mammalian Germline Genome Engineering

bioRxivDecember 22, 2019
Yanan YueLuhan Yang
196
2
1
Nature Communications

Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

Nature CommunicationsJanuary 9, 2020
Dimitrios PapaioannouRamiro Garzon
1
Cell

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

CellDecember 10, 2019
Nicole Y LaiIsaac M Chiu
147
7
1
1
bioRxiv

Thrombospondin-1 Promotes Circuit-Specific Synapse Formation via β1-Integrin

bioRxivDecember 9, 2019
Sehwon KohCagla Eroglu
42
bioRxiv

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease and progressive supranuclear palsy converge on altered glial regulation

bioRxivNovember 30, 2019
Kathryn R BowlesAlison Goate
13
bioRxiv

Machine learning on drug-specific data to predict small molecule teratogenicity

bioRxivNovember 30, 2019
Anup P. ChallaDavid M. Aronoff
15
bioRxiv

Auto-regulatory J-domain interactions control Hsp70 recruitment in the oligomeric DNAJB8 co-chaperone

bioRxivJanuary 9, 2020
Bryan D RyderLukasz A Joachimiak
4
JAMA Neurology

Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy

JAMA NeurologyJanuary 7, 2020
William G MantyhGil D Rabinovici
76
3
Science Advances

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia

Science AdvancesDecember 18, 2019
Kirusanthy KaneshwaranAndrew S P Lim
157
2
1
ACS Chemical Biology

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

ACS Chemical BiologyJanuary 14, 2020
Raphael I BenhamouMatthew D Disney
33
Cell Systems

Protein Structure from Experimental Evolution

Cell SystemsDecember 16, 2019
Michael A StifflerChris Sander
61
1
Cell

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

CellDecember 14, 2019
Michaela AspJoakim Lundeberg
138
4
Trends in Genetics : TIG

Omics in Neurodegenerative Disease: Hope or Hype?

Trends in Genetics : TIGJanuary 15, 2020
Maria E Diaz-Ortiz, Alice S Chen-Plotkin
28
1
Angewandte Chemie

Site-specific hyperphosphorylation inhibits, rather than promotes, tau fibrillization, seeding capacity and its microtubule binding

Angewandte ChemieDecember 22, 2019
Mahmood Haj-YahyaHilal A Lashuel
7
1
Nature Reviews. Neuroscience

Tissue clearing and its applications in neuroscience

Nature Reviews. NeuroscienceJanuary 4, 2020
Hiroki R UedaPhilipp J Keller
193
1
Neurobiology of Disease

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of DiseaseJanuary 14, 2020
Heather HulmePer E Andrén
4
1
Acta Neuropathologica

Overlapping genetic architecture between Parkinson disease and melanoma

Acta NeuropathologicaDecember 18, 2019
Umber DubeCarlos Cruchaga
28
1
Neuron

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

NeuronDecember 14, 2019
Lien NguyenLaura P W Ranum
19
2
JAMA Neurology

Overcoming Neurophobia With the Help of Peruvian Talking Bears

JAMA NeurologyJanuary 14, 2020
Brian DewarMichel C F Shamy
11

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