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CZI Neurodegeneration Challenge Network

CZI Neurodegeneration Challenge Network diagram by Frank Gaillard, Wikimedia
Frank Gaillard, Wikimedia

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

Top 20 most recent papers

A Deep Learning Approach to Antibiotic Discovery

CellFebruary 22, 2020
Jonathan M StokesJames J Collins
Nature Medicine

Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration

Nature MedicineMarch 4, 2020
Elisabeth H ThijssenAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators
Nature Medicine

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

Nature MedicineMarch 13, 2020
Nicolas R BarthélemyDominantly Inherited Alzheimer Network
Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning

Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationFebruary 12, 2020
Nicolai FranzmeierMichael Ewers

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

bioRxivMarch 26, 2020
Nazia AbbasiWendy Jia Men Huang

Neuro-immune Interactions in the Tissues

ImmunityMarch 19, 2020
Coco ChuIsaac M Chiu
Nature Reviews. Neuroscience

Publisher Correction: Tissue clearing and its applications in neuroscience

Nature Reviews. NeuroscienceMarch 11, 2020
Hiroki R UedaPhilipp J Keller
Cell Research

Expanding the AtLAS of non-coding RNA functions in the brain

Cell ResearchMarch 1, 2020
Matthew J Regier, Jason D Shepherd

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Human Vascular Endothelial Cell Atlas: Young & Old

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Chronic Fatigue Syndrome

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Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Incretin & Type 1 Diabetes

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Allen Institute for Brain Science Network (MDS)

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Severe Acute Respiratory Syndrome

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Computation Neuroscience - Preprints (MDS)

Computation neuroscience employs models, statistics, simulations, and theoretical analyses to understand mechanisms that govern neural functions. Here are the latest preprints in this domain.

LRRK2 & Immunity During Infection (MDS)

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

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