Deficiency of Adenosine Deaminase 2 (DADA2)

First reported in 2014, deficiency of adenosine deaminase 2 (DADA2) is a genetic disease affecting the blood vessels and the immune system. This disease results in a range of symptoms that may include recurrent strokes, severe systemic inflammation, immune deficiency, and damage to many of the body's tissues and organs. As an extremely rare condition, there is still much to learn. Find the latest research on DADA2 in this feed.

February 24, 2021

Systematic evaluation of nine monogenic autoinflammatory diseases reveals common and disease-specific correlations with allergy-associated features.

Annals of the Rheumatic Diseases
Daniella Muallem SchwartzPamela Frischmeyer-Guerrerio
February 23, 2021

Clinical Features and Outcomes of Childhood Polyarteritis Nodosa: A Single Referral Center Experience.

Modern Rheumatology
Nilüfer TekgözBanu Acar
February 21, 2021

Biologic drugs in the treatment of polyarteritis nodosa and deficit of adenosine deaminase 2: A narrative review.

Autoimmunity Reviews
Edoardo ConticiniLuca Cantarini
February 1, 2021
Open Access

Novel ADA2 Compound Heterozygous Mutations Resulting in Deficiency of Adenosine Deaminase 2 in a Pair of Siblings.

Journal of Clinical Immunology
Li GuoQing Zhou
January 30, 2021
Open Access

Polyarteritis Nodosa: A Systematic Review of Test Accuracy and Benefits and Harms of Common Treatments.

ACR Open Rheumatology
Yih Chang LinReem A Mustafa
December 30, 2020
Open Access

Diagnosis and management of Adenosine Deaminase 2 Deficiency children: the experience from China

Wei WangHongmei Song
September 7, 2020

Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India.

Arthritis & Rheumatology
Aman SharmaPui Y Lee
August 28, 2020
Open Access

The Many Faces of a Monogenic Autoinflammatory Disease: Adenosine Deaminase 2 Deficiency

Current Rheumatology Reports
Jennifer Lee Kendall, Jason M Springer
August 17, 2020

Deficiency of Adenosine Deaminase 2 (DADA2) - A New Autoinflammatory Disease with Multisystem Features

Indian Pediatrics
Raju Khubchandani, Ivona Aksentijevich
July 25, 2020

Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients.

European Journal of Immunology
Francesca SchenaMarco Gattorno
July 12, 2020
Open Access

Adenosine deaminase 2 activity negatively correlates with age during childhood

Pediatric Rheumatology Online Journal
Sarah M BowersKelly L Brown
July 9, 2020

Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance

Journal of Clinical Immunology
Oskar SchnappaufIvona Aksentijevich

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